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Article
Open AccessFrom wings to whiskers to stem cells: why every model matters in fragile X syndrome research
Fragile X syndrome (FXS) is caused by epigenetic silencing of the X-linked fragile X messenger ribonucleoprotein 1 (FMR1) gene located on chromosome Xq27.3, which leads to the loss of its protein product, fragile...
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Article
Open AccessConvergent and divergent intra- and internetwork connectivity in Parkinson’s disease with wearing-off
Our study aimed to explore the functional connectivity alterations between cortical nodes of resting-state networks in Parkinson’s disease (PD) patients with wearing-off (WO) at different levels.
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Article
Open AccessAlzheimer’s pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome
Traumatic encephalopathy syndrome (TES) is a clinical phenotype sensitive but non-specific to underlying chronic traumatic encephalopathy (CTE) neuropathology. However, cognitive symptoms of TES overlap with A...
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Article
Open AccessReal-world outcomes of teriflunomide in relapsing–remitting multiple sclerosis: a prospective cohort study
To explore efficacy, risk factors, safety, and persistence of teriflunomide in relapsing–remitting multiple sclerosis (RRMS) cohort.
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Article
Correction to: 3-Hz Postural Tremor in MSA-C and SCA: Revisiting an Old but Underestimated Cerebellar Sign by Posturography
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Article
Open AccessAstrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors
Little is known about how the obesogenic environment influences emotional states associated with glial responses and neuronal function. Here, we investigated glial reactivation and neuronal electrophysiologica...
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Article
Open AccessRegional homogeneity alterations in multi-frequency bands in tension-type headache: a resting-state fMRI study
In this study, we aimed to investigate the spontaneous neural activity in the conventional frequency band (0.01−0.08 Hz) and two sub-frequency bands (slow-4: 0.027–0.073 Hz, and slow-5: 0.01–0.027 Hz) in tensi...
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Article
Correction to: Association Study Between Genetic Variation in Whole Mitochondrial Genome and Ischemic Stroke
A correction to this paper has been published: https://doi.org/10.1007/s12031-021-01833-7
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Article
Open AccessThe progression of intracerebral hemorrhage (ICH) is related to the expression of integrin Β1 (ITGB1)
Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (...
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Article
Open AccessCharacteristic of Parkinson’s disease with severe COVID-19: a study of 10 cases from Wuhan
Information about Parkinson’s disease (PD) patients with severe COVID-19 is scarce. We aimed to analyze the clinical characteristics, outcomes, and risk factors affecting the prognosis of PD patients with seve...
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Article
Open AccessTargeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury
Traumatic brain injury (TBI) is a major cause of CNS neurodegeneration and has no disease-altering therapies. It is commonly associated with a specific type of biomechanical disruption of the axon called traum...
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Article
Open AccessThe prognostic value of total T3 after acute cerebral infarction is age-dependent: a retrospective study on 768 patients
Serum triiodothyronine (T3) concentration was reported to be associated with the prognosis after acute ischemic stroke. The aim of this study was to evaluate the effect of age on the prognostic value of thyroi...
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Article
Open AccessAcute-onset multiple acyl-CoA dehydrogenase deficiency mimicking Guillain-Barré syndrome: two cases report
Multiple acyl-CoA dehydrogenase deficiency (MADD) showed great clinical heterogeneity and poses a challenge to diagnosis. Guillain-Barré syndrome (GBS) is an acute-onset autoimmune-mediated peripheral neuropat...
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Article
Open AccessRNAseq analysis of hippocampal microglia after kainic acid-induced seizures
Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these cells undergo following seizure induction is not well ...
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Article
Open AccessNeuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration
Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is associated with the accumulation of pathological neuronal and glial intracytoplasmic inclusions as well as accompanying neuron loss. We ex...
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Article
Open AccessBioinformatics analysis of glial inflammatory responses to air pollution
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Article
Open AccessCaregiver burden in schizophrenia following paliperidone palmitate long acting injectables treatment: pooled analysis of two double-blind randomized phase three studies
The pooled analysis of two double-blind, randomized, multicenter, phase-3 studies evaluated predictors of improvement or worsening of schizophrenia-related caregiver burden following paliperidone palmitate lon...
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Article
Open AccessSerum high-density lipoprotein correlates with serum apolipoprotein M and A5 in obstructive sleep apnea hypopnea syndrome
The purpose of this study was to investigate the correlation between serum levels of serum apolipoprotein M (ApoM), A5 (ApoA5), and high-density lipoprotein (HDL) in patients with obstructive sleep apnea hypop...
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Article
Open AccessGranulomatous hypophysitis: experience with eight surgical cases of a single center
Although primary hypophysitis is not uncommon, a granulomatous etiology of hypophysitis is relatively rare. Radiological and diagnostic characteristics of several isolated cases have been described to date. Ho...
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Article
Open AccessSexually dimorphic outcomes and inflammatory responses in hypoxic-ischemic encephalopathy
Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of motor and cognitive impairment in children. Clinically, male infants are more vulnerable to ischemic insults and suffer more long-term de...
