32 Result(s)
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**xia Ma
Cancer Research
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Article
Open AccessSequence variations in DNA repair gene XPCis associated with lung cancer risk in a Chinese population: a case-control study
The nucleotide excision repair (NER) protein, xeroderma pigmentosum C (XPC), participates in recognizing DNA lesions and initiating DNA repair in response to DNA damage. Because mutations in XPC cause a high risk...
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Open AccessContinuous and low-energy 125I seed irradiation changes DNA methyltransferases expression patterns and inhibits pancreatic cancer tumor growth
Iodine 125 (125I) seed irradiation is an effective treatment for unresectable pancreatic cancers. However, the radiobiological mechanisms underlying brachytherapy remain unclear. Therefore, we investigated the in...
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Open AccessAssociation between novel PLCE1variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck
Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase family plays crucial roles in carcinogenesis and progression of several cancers, including squamous cell carcinoma of the h...
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Open AccessTNFRSF1B +676 T>G polymorphism predicts survival of non-Small cell lung cancer patients treated with chemoradiotherapy
The dysregulation of gene expression in the TNF-TNFR superfamily has been involved in various human cancers including non-small cell lung cancer (NSCLC). Furthermore, functional polymorphisms in TNF-α and TNFRSF1...
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Open AccessBreast cancer risk assessment with five independent genetic variants and two risk factors in Chinese women
Recently, several genome-wide association studies (GWAS) have identified novel single nucleotide polymorphisms (SNPs) associated with breast cancer risk. However, most of the studies were conducted among Cauca...
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Open AccessEvaluation of functional genetic variants at 6q25.1 and risk of breast cancer in a Chinese population
Single-nucleotide polymorphisms (SNPs) at 6q25.1 that are associated with breast cancer susceptibility have been identified in several genome-wide association studies (GWASs). However, the exact causal variant...
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Mechanistic Role of MicroRNA in Cancer Chemoprevention by Nonsteroidal Anti-inflammatory Drugs
Over the past several decades, studies have documented the cancer chemopreventive activity of nonsteroidal anti-inflammatory drugs (NSAIDs) by lowering incidence and slowing down progression of malignant disea...
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Open AccessAssociation of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case–control study
MicroRNA (miRNA) polymorphisms may alter miRNA-related processes, and they likely contribute to cancer susceptibility. Various studies have investigated the associations between genetic variants in several key...
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Open AccessHuman snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion
Genetic searches for tumor suppressors have recently linked small nucleolar RNA misregulations with tumorigenesis. In addition to their classically defined functions, several small nucleolar RNAs are now known...
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Polymorphisms in CARS are associated with gastric cancer risk: a two-stage case–control study in the Chinese population
The cysteinyl transfer RNA synthetase gene (CARS) is located on chromosome band 11p15.5, which is an important tumor-suppressor gene region. Mutations in CARS have been identified in many kinds of cancers; howeve...
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Multi-marker analysis of genomic annotation on gastric cancer GWAS data from Chinese populations
Gastric cancer (GC) is one of the high-incidence and high-mortality cancers all over the world. Though genome-wide association studies (GWASs) have found some genetic loci related to GC, they could only explai...
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Open AccessBlood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review
The association of ABO blood groups with gastric cancer risk was proposed decades ago, but the results have been inconsistent.
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Open AccessPrognostic significance of TOP2A in non-small cell lung cancer revealed by bioinformatic analysis
Lung cancer has been a common malignant tumor with a leading cause of morbidity and mortality, current molecular targets are woefully lacking comparing to the highly progressive cancer. The study is designed t...
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Open AccessAssociation of TM6SF2 rs58542926 T/C gene polymorphism with hepatocellular carcinoma: a meta-analysis
Hepatocellular carcinoma (HCC) is the sixth-most common malignancy worldwide. Multiple previous studies have assessed the relationship between TM6SF2 gene polymorphism and the risk of develo** HCC, with disc...
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Open AccessMutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1
Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, and is associated with a poor prognosis due to frequent distant metastasis and lack of effective targeted therapies. Previousl...
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Open AccessComparison of nonhuman primates identified the suitable model for COVID-19
Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains challenging. Here, we characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in three NHP species: Ol...
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Open AccessThe biologically functional identification of a novel TIM3-binding peptide P26 in vitro and in vivo
Recent studies have shown that TIM3 plays an important role in T-cell failure, which is closely related to the resistance to anti-programmed cell death protein 1 (PD-1) treatment. However, there have been no r...
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Open AccessAdverse reactions of targeted therapy in cancer patients: a retrospective study of hospital medical data in China
The adverse reactions (ADRs) of targeted therapy were closely associated with treatment response, clinical outcome, quality of life (QoL) of patients with cancer. However, few studies presented the correlation...
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Open AccessBioinformatic analysis identifying FGF1 gene as a new prognostic indicator in clear cell Renal Cell Carcinoma
Clear cell renal cell carcinoma (ccRCC) has been the commonest renal cell carcinoma (RCC). Although the disease classification, diagnosis and targeted therapy of RCC has been increasingly evolving attributing ...
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Open AccessThe olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys
Neurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of SARS-CoV-2 neurotropism via our...
