32 Result(s)
within
**xia Ma
Cancer Research
-
Article
Open AccessUSP47 deficiency in mice modulates tumor infiltrating immune cells and enhances antitumor immune responses in prostate cancer
This study investigates the role of USP47, a deubiquitinating enzyme, in the tumor microenvironment and its impact on antitumor immune responses. Analysis of TCGA database revealed distinct expression patterns...
-
Article
Open AccessCorrection: The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth
-
Article
Open AccessThe novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth
The most aggressive form of breast cancer is triple-negative breast cancer (TNBC), which lacks expression of the estrogen receptor (ER) and progesterone receptor (PR), and does not have overexpression of the h...
-
Article
Open AccessPreoperative assessment of peripheral vascular invasion of pancreatic ductal adenocarcinoma based on high-resolution MRI
Preoperative imaging of vascular invasion is important for surgical resection of pancreatic ductal adenocarcinoma (PDAC). However, whether MRI and CT share the same evaluation criteria remains unclear. This st...
-
Article
Correction to: IL‑17A promotes fatty acid uptake through the IL‑17A/IL‑17RA/ p‑STAT3/FABP4 axis to fuel ovarian cancer growth in an adipocyte‑rich microenvironment
-
Article
Open AccessImmune regulation and prognosis indicating ability of a newly constructed multi-genes containing signature in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy, although newly develo** targeted therapy and immunotherapy have been showing promising effects in clinical treatment, the effectiv...
-
Article
Open AccessInhibition of CXorf56 promotes PARP inhibitor-induced cytotoxicity in triple-negative breast cancer
Poly(ADP-ribose) polymerase inhibitors (PARPis) induce DNA lesions that preferentially kill homologous recombination (HR)-deficient breast cancers induced by BRCA mutations, which exhibit a low incidence in breas...
-
Article
Open AccessAssociation of Helicobacter pylori infection with survival outcomes in advanced gastric cancer patients treated with immune checkpoint inhibitors
Accumulating evidence has revealed that the gut microbiota influences the effectiveness of immune checkpoint inhibitors (ICIs) in cancer patients. As a part of the human microbiome, Helicobacter pylori (H. pylori...
-
Article
Open AccessThe relationship between medication literacy and skin adverse reactions in non-small-cell lung cancer patients undergoing targeted EGFR-TKI therapy
High medication literacy is the basis of rational medication application and is essential for the management of severe adverse drug reactions. The objective of the present study was to assess the level of medi...
-
Article
Open AccessDelivery of CXCL9/10/11 plasmid DNAs promotes the tumor-infiltration of T cells and synergizes with PD1 antibody for treating lung cancer
Immune checkpoint blockade (ICB)-based cancer immunotherapy presents promising efficacy in cancer treatment. However, only a small portion of patients show responsiveness to the treatment, which is partially c...
-
Article
Open AccessAzvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients
Azvudine (FNC) is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase (RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into Phase III trial for COVID-19 patie...
-
Article
Open AccessIMUP and GPRC5A: two newly identified risk score indicators in pancreatic ductal adenocarcinoma
Pancreatic cancer has been a threateningly lethal malignant tumor worldwide. Despite the promising survival improvement in other cancer types attributing to the fast development of molecular precise medicine, ...
-
Article
Open AccessThe olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys
Neurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of SARS-CoV-2 neurotropism via our...
-
Article
Open AccessBioinformatic analysis identifying FGF1 gene as a new prognostic indicator in clear cell Renal Cell Carcinoma
Clear cell renal cell carcinoma (ccRCC) has been the commonest renal cell carcinoma (RCC). Although the disease classification, diagnosis and targeted therapy of RCC has been increasingly evolving attributing ...
-
Article
Open AccessAdverse reactions of targeted therapy in cancer patients: a retrospective study of hospital medical data in China
The adverse reactions (ADRs) of targeted therapy were closely associated with treatment response, clinical outcome, quality of life (QoL) of patients with cancer. However, few studies presented the correlation...
-
Article
Open AccessThe biologically functional identification of a novel TIM3-binding peptide P26 in vitro and in vivo
Recent studies have shown that TIM3 plays an important role in T-cell failure, which is closely related to the resistance to anti-programmed cell death protein 1 (PD-1) treatment. However, there have been no r...
-
Article
Open AccessComparison of nonhuman primates identified the suitable model for COVID-19
Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains challenging. Here, we characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in three NHP species: Ol...
-
Article
Open AccessMutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1
Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, and is associated with a poor prognosis due to frequent distant metastasis and lack of effective targeted therapies. Previousl...
-
Article
Open AccessAssociation of TM6SF2 rs58542926 T/C gene polymorphism with hepatocellular carcinoma: a meta-analysis
Hepatocellular carcinoma (HCC) is the sixth-most common malignancy worldwide. Multiple previous studies have assessed the relationship between TM6SF2 gene polymorphism and the risk of develo** HCC, with disc...
-
Article
Open AccessPrognostic significance of TOP2A in non-small cell lung cancer revealed by bioinformatic analysis
Lung cancer has been a common malignant tumor with a leading cause of morbidity and mortality, current molecular targets are woefully lacking comparing to the highly progressive cancer. The study is designed t...
