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Article
Open AccessDivergent histopathological and molecular patterns in chemically induced interstitial cystitis/bladder pain syndrome rat models
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a complex chronic pain disorder with an elusive etiology and nonspecific symptoms. Although numerous animal models with phenotypes similar to human disea...
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Article
Clinical characteristics of membranous nephropathy after allogeneic hematopoietic stem cell transplantation: A real-world multicenter study
Membranous nephropathy (MN) is a rare complication that can occur after allogeneic hematopoietic stem cell transplantation (allo-HSCT). MN patients may develop nephrotic syndrome or even kidney failure, which ...
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Article
The E2F family: a ray of dawn in cardiomyopathy
Cardiomyopathies are a group of heterogeneous diseases, characterized by abnormal structure and function of the myocardium. For many years, it has been a hot topic because of its high morbidity and mortality a...
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Article
Conservation genomics of the critically endangered Chinese pangolin
The Chinese pangolin (Manis pentadactyla, MP) has been extensively exploited and is now on the brink of extinction, but its population structure, evolutionary history, and adaptive potential are unclear. Here, we...
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Article
Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway–mediated neuroinflammation in db/db mice
Diabetes mellitus (DM), an important public health problem, aggravates the global economic burden. Diabetic encephalopathy (DE) is a serious complication of DM in the central nervous system. Metformin has been...
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Article
Conditional Survival of Patients with Limited-Stage Small Cell Lung Cancer After Surgery: A National Real-World Cohort Study
The prognosis of limited-stage small cell lung cancer (LS-SCLC) after surgery usually is estimated at diagnosis, but how the prognosis actually evolves over time for patients who survived for a predefined time...
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Article
Open AccessPEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3
The peroxisome is a versatile organelle that performs diverse metabolic functions. PEX3, a critical regulator of the peroxisome, participates in various biological processes associated with the peroxisome. Whe...
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Article
Open AccessGrowing on patch boundaries of heterogeneous soils promotes root growth but not the total biomass of naturalized alien and native plants
Soil heterogeneity has been found to promote plant invasion, as many naturalized alien species benefit more from nutrient-rich patches than native species do. However, it remains unclear whether naturalized al...
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Article
Open AccessNanoconfinement steers nonradical pathway transition in single atom fenton-like catalysis for improving oxidant utilization
The introduction of single-atom catalysts (SACs) into Fenton-like oxidation promises ultrafast water pollutant elimination, but the limited access to pollutants and oxidant by surface catalytic sites and the i...
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Article
Growth and Physiological Responses of Blackberry Seedlings to Different NH4+:NO3− Ratios
In order to reveal the regulator mechanism of different NH4+:NO3− ratios on the growth and development of blackberry seedlings for the first time. We explored the effect of different NH4+:NO3− ratios on growth pa...
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Article
Open AccessA Lactobacillus Combination Ameliorates Lung Inflammation in an Elastase/LPS—induced Mouse Model of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is the world's leading lung disease and lacks effective and specific clinical strategies. Probiotics are increasingly used to support the improvement of the course ...
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Article
Open AccessImpact of background music listening on anxiety in cancer patients undergoing initial radiation therapy: a randomized clinical trial
Patients undergoing radiation therapy (RT) often experience anxiety, which may jeopardize the treatment success. The efficacy of music interventions in reducing anxiety remains contentious. This randomized tri...
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Article
Open AccessCorrection: Targeting STAT3 by a small molecule suppresses pancreatic cancer progression
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Article
Radiomics features based on dual-area CT predict the expression levels of fatty acid binding protein 4 and outcome in hepatocellular carcinoma
To evaluate the predictive value of tumor and peritumor radiomics in the fatty acid binding protein 4 (FABP4) expression levels and overall survival in patients with hepatocellular carcinoma.
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Article
Geographical patterns and determinants of insect biodiversity in China
Insects play important roles in the maintenance of ecosystem functioning and the provision of livelihoods for millions of people. However, compared with terrestrial vertebrates and angiosperms, such as the gia...
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Article
Open AccessLink Brain-Wide Projectome to Neuronal Dynamics in the Mouse Brain
Knowledge about the neuronal dynamics and the projectome are both essential for understanding how the neuronal network functions in concert. However, it remains challenging to obtain the neural activity and th...
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Article
Open AccessMiniaturized all-in-one microneedle device for point of care light therapy
Light therapies have been applied to millions of patients for treating many kinds of diseases, especially superficial ones. Currently, mainstream light therapies utilize the combined effects of photosensitizer...
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Article
Molecular Cloning and Functional Analysis of ScHAK10 Gene Promoter from Sugarcane (Saccharum officinarum L.)
Transcriptional regulation of the high-affinity K+ (HAK) transporter gene is an important mechanism of plant response to low potassium stress. Cloning and analysis of the promoter of potassium transporter gene is...
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Article
Open AccessIsolation and expression analysis of cellulose synthase 3 (Ces3) genes from sugarcane (Saccharum officinarum L.)
Plant cellulose synthase is one of the important glycosyltransferases, which catalyzes the synthesis of the paracrystalline of H-bonded-β-(1,4)-glucose chains. This study isolated the cellulose synthase 3 (Ces3) ...
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Spatial-temporal population dynamics of the critically endangered Blue-crowned Laughingthrush Pterorhinus courtoisi: a 22-year longitudinal study
