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Article
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Energy metabolism has always been a hot topic in cancer progression and targeted therapy, and exploring the role of genes in energy metabolic pathways in cancer cells has become key to address this issue. Euka...
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Article
Diversity and environmental determinants of aquatic plants across China
Aquatic plants play an important role in aquatic systems. A comprehensive understanding of their spatial distribution may help to develop biodiversity conservation plans. This work investigated the spatial dis...
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Article
Feasibility study on fruit parameter estimation based on hyperspectral LiDAR point cloud
Fruit parameter estimation is beneficial to intelligent management of orchards. This study proposed a compound method to estimate the fruit ripeness, number and size based on hyperspectral three-dimensional (3...
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Article
Predictors of Toxic Metal/Metalloid Exposures Among Mexican Americans in Starr County, Texas
Arsenic, cadmium, and lead are toxic elements that widely contaminate our environment. These toxicants are associated with acute and chronic health problems, and evidence suggests that minority communities, in...
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Article
An anti-CRISPR that pulls apart a CRISPR–Cas complex
In biological systems, the activities of macromolecular complexes must sometimes be turned off. Thus, a wide variety of protein inhibitors has evolved for this purpose. These inhibitors function through divers...
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Article
DCTGM: A Novel Dual-channel Transformer Graph Model for miRNA-disease Association Prediction
Studies have shown that as non-coding RNAs, miRNAs regulate all levels of life activities and most pathological processes. Therefore, identifying disease-related miRNAs is essential for disease diagnosis and t...
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Article
Naked-eye visualization of lymph nodes using fluorescence nanoprobes in non-human primate-animal models
Despite sufficient studies performed in non-primate animal models, there exists scanty information obtained from pilot trials in non-human primate animal models, severely hindering nanomaterials moving from ba...
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Article
Enhancing Digital Economy: Optimizing Export Enterprise Markup and Resource Allocation Efficiency
The digital economy transforms global trade, creating new opportunities for exporters and sectors to improve international competitiveness. To understand the digital economy’s complex effects on microenterpris...
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Article
Comprehensive investigation of a dangerous counter-tilt landslide in the upper reaches of **sha River, China
Timely and detailed investigation of dangerous landslides is crucial for preventing catastrophic disasters. On June 29, 2023, the local collapse of the Mengu landslide in the upper reaches of **sha River in Q...
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Article
Open AccessCoenzyme Q deficiency may predispose to sudden unexplained death via an increased risk of cardiac arrhythmia
Cardiac arrhythmia is currently considered to be the direct cause of death in a majority of sudden unexplained death (SUD) cases, yet the genetic predisposition and corresponding endophenotypes contributing to...
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Article
Open AccessMechanistic prediction and validation of Brevilin A Therapeutic effects in Lung Cancer
Traditional Chinese medicine (TCM) has been found widespread application in neoplasm treatment, yielding promising therapeutic candidates. Previous studies have revealed the anti-cancer properties of Brevilin ...
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Article
Recent advances in formaldehyde sensors: a review
Formaldehyde (HCHO), a common industrial compound, presents major health hazards to people, underscoring the importance of HCHO sensor development in public health surveillance. This review encapsulates the ad...
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Article
Open AccessCorrection: Pancancer analysis of the prognostic and immunological role of FANCD2: a potential target for carcinogenesis and survival
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Article
Analysis of Salt Stress on Soil Microbial Community Composition and Its Correlation with Active Components in the Rhizosphere of Acanthopanax senticosus
Salt stress can adversely affect plant seed germination, growth and development, and eventually lead to slow growth and even death of plants. The purpose of this study was to investigate the effects of differe...
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Article
Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells promote alveolar bone regeneration by regulating macrophage polarization
Alveolar bone regeneration has been strongly linked to macrophage polarization. M1 macrophages aggravate alveolar bone loss, whereas M2 macrophages reverse this process. Berberine (BBR), a natural alkaloid iso...
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Article
Interannual variability of diurnal temperature range in CMIP6 projections and the connection with large-scale circulation
Diurnal temperature range (DTR), as a core indicator of the Earth system, exhibits obvious temporal and spatial variations, which is not entirely consistent over global. The historical simulation capabilities ...
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Article
Open AccessDiscovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs
CRISPR-Cas systems and IS200/IS605 transposon-associated TnpBs have been utilized for the development of genome editing technologies. Using bioinformatics analysis and biochemical experiments, here we present ...
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Article
Novel IPT system for enhanced efficiency and anti-misalignment capability
Inductive power transfer (IPT) systems are playing an increasingly important role in electric vehicles, rail transit, industrial production and daily life. In the above practical applications, the misalignment...
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Article
Open AccessExpression and functional significance of phosphoenolpyruvate carboxykinase 1 in uveal melanoma
Uveal melanoma (UVM), an uncommon yet potentially life-threatening ocular cancer, arises from melanocytes in the uveal tract of the eye. The exploration of novel oncotargets for UVM is of paramount importance....
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Article
Open AccessThe chromosome-level genome assembly of the giant dobsonfly Acanthacorydalis orientalis (McLachlan, 1899)
Acanthacorydalis orientalis (McLachlan, 1899) (Megaloptera: Corydalidae) is an important freshwater-benthic invertebrate species that serves as an indicator for water-quality biomonitoring and is valuable for con...
