60 Result(s)

Article

The immunotoxin targeting PRLR increases tamoxifen sensitivity and enhances the efficacy of chemotherapy in breast cancer

Though tamoxifen achieves success in treating estrogen receptor α (ERα)-positive breast cancer, the followed development of tamoxifen resistance is a common challenge in clinic. Signals downstream of prolactin...

Jiawei Zhang, Junjun Liu, Yali Yue, Lei Wang… in Journal of Experimental & Clinical Cancer … (2024)

Article

Development and validation of an inflammatory biomarkers model to predict gastric cancer prognosis: a multi-center cohort study in China

Inflammatory factors have increasingly become a more cost-effective prognostic indicator for gastric cancer (GC). The goal of this study was to develop a prognostic score system for gastric cancer patients bas...

Shaobo Zhang, Hongxia Xu, Wei Li, Jiuwei Cui, Qingchuan Zhao, Zengqing Guo… in BMC Cancer (2024)

Article

Outcome in patients with HIV-associated Hodgkin lymphoma treated with chemotherapy using Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine in the combination antiretroviral therapy (cART) era: results of a multicenter study from China

Little is known about the outcome for HIV-associated Hodgkin lymphoma (HIV-HL) as this is less common than HIV-negative lymphoma. Therefore, we performed a multi-center study to analyze the clinical characteri...

Lirong **ao, Chaoyu Wang, Sai Ma, Yifan Wang, Li** Guan… in Infectious Agents and Cancer (2024)

Article

IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis

Nasopharyngeal carcinoma (NPC) poses a significant health burden in specific regions of Asia, and some of NPC patients have bone metastases at the time of initial diagnosis. Bone metastasis can cause pathologi...

Kaifan Yang, Yanjun Hu, Yuanyuan Feng… in Journal of Experimental & Clinical Cancer … (2024)

Article

EGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL

Hepatocellular Carcinoma (HCC) is a matter of great global public health importance; however, its current therapeutic effectiveness is deemed inadequate, and the range of therapeutic targets is limited. The ai...

Mingang Pan, Muyu Luo, Lele Liu… in Journal of Experimental & Clinical Cancer … (2024)

Article

RGCC-mediated PLK1 activity drives breast cancer lung metastasis by phosphorylating AMPKα2 to activate oxidative phosphorylation and fatty acid oxidation

More than 90% of the mortality of triple-negative breast cancer (TNBC) patients is attributed to cancer metastasis with organotropism. The lung is a frequent site of TNBC metastasis. However, the precise molec...

Shaojie Cheng, Xueying Wan, Li** Yang… in Journal of Experimental & Clinical Cancer … (2023)

Article

CT-based deep learning model: a novel approach to the preoperative staging in patients with peritoneal metastasis

Peritoneal metastasis (PM) is a frequent manifestation of advanced abdominal malignancies. Accurately assessing the extent of PM before surgery is essential for patients to receive optimal treatment. Therefore...

Jipeng Wang, Yuannan Hu, Hao **ong, Tiantian Song… in Clinical & Experimental Metastasis (2023)

Article

Cytokine release syndrome was an independent risk factor associated with hypoalbuminemia for patients with relapsed/refractory hematological malignancies after CAR-T cell therapy

This study aims to assess the nutritional status of patients during the different phases of the Chimeric Antigen Receptor (CAR)-T cell therapy and to identify prominent risk factors of hypoalbuminemia in patie...

Shuyi Ding, Rongrong Chen, Linqin Wang, Cheng Zu, **aoyu Zhou, Jianli Zhang… in BMC Cancer (2023)

Article

Tumor cell-induced platelet aggregation accelerates hematogenous metastasis of malignant melanoma by triggering macrophage recruitment

Tumor cell-induced platelet aggregation (TCIPA) is not only a recognized mechanism for paraneoplastic thrombocytosis but also a potential breakthrough alternative for a low response to immune checkpoint inhibi...

Yuyi Chen, Jie Zhou, Zishen Liu, Tongtong Wu… in Journal of Experimental & Clinical Cancer … (2023)

Article

Development and validation a radiomics nomogram for predicting thymidylate synthase status in hepatocellular carcinoma based on Gd-DTPA contrast enhanced MRI

The purpose of this study was to develop and validate a radiomics nomogram for predicting thymidylate synthase (TYMS) status in hepatocellular carcinoma (HCC) by using Gd-DTPA contrast enhanced MRI.

Zongren Ding, Yijun Wu, Guoxu Fang, Zhaowang Lin, Kongying Lin, Jun Fu… in BMC Cancer (2023)

Article

Integrative analysis of the prognostic value and immune microenvironment of mitophagy-related signature for multiple myeloma

Multiple myeloma (MM) is a fatal malignant tumor in hematology. Mitophagy plays vital roles in the pathogenesis and drug sensitivity of MM.

Yachun Jia, Rui Liu, Luyi Shi, Yuandong Feng, Linlin Zhang, Ni Guo, Aili He… in BMC Cancer (2023)

Article

Combination of RUNX1 inhibitor and gemcitabine mitigates chemo‐resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress

Gemcitabine (GEM)-based chemotherapy is the first-line option for pancreatic ductal adenocarcinoma (PDAC). However, the development of drug resistance limits its efficacy, and the specific mechanisms remain la...

Chunhua She, Chao Wu, Weihua Guo… in Journal of Experimental & Clinical Cancer … (2023)

Article

Retraction Note: N6-methyladenosine induced mir-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1

Hongsheng Wang, Qianqian Deng, Ziyan Lv, Yuyi Ling, Xue Hou… in Molecular Cancer (2023)

Article

Identification of SPRYD4 as a tumour suppressor predicts prognosis and correlates with immune infiltration in cholangiocarcinoma

Cholangiocarcinoma (CCA) is an aggressive solid tumour with a 5-year survival rate ranging from 7% to 20%. It is, therefore, urgent to identify novel biomarkers and therapeutic targets to improve the outcomes ...

Zuyi Ma, Tiange **e, Jia Sun, Jianchun Yu, Shanzhou Huang, Qi Zhou, Binglu Li in BMC Cancer (2023)

Article

Predicting breast cancer types on and beyond molecular level in a multi-modal fashion

Accurately determining the molecular subtypes of breast cancer is important for the prognosis of breast cancer patients and can guide treatment selection. In this study, we develop a deep learning-based model ...

Tianyu Zhang, Tao Tan, Luyi Han, Linda Appelman, Jeroen Veltman… in npj Breast Cancer (2023)

Article

Relationship between tumor microbiota transcriptional activity and gene expression in breast cancer

A few studies have reported the distribution of the microbiota in breast cancer tissues, but few reports have compared the microbiota in different subtypes of breast cancer tissue. Moreover, no study has repor...

Enuo Liu, Fan Zhang, Tiansheng Xu, Luyi Ye, Sean Si Qian Ma, Zai-Si Ji in BMC Cancer (2023)

Article

An overview of hyperbaric oxygen preconditioning against ischemic stroke

Ischemic stroke (IS) has become the second leading cause of morbidity and mortality worldwide, and the prevention of IS should be given high priority. Recent studies have indicated that hyperbaric oxygen preco...

Xuyi Wu, Jiuhong You, **nxin Chen, Mei Zhou, Hui Ma… in Metabolic Brain Disease (2023)

Article

Proposed prognostic subgroups and facilitated clinical decision-making for additional locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: a retrospective study based on recursive partitioning analysis

The high heterogeneity of de novo metastatic nasopharyngeal carcinoma (dmNPC) makes its prognosis and treatment challenging. We aimed to accurately stage dmNPC and assess the patterns of treatment strategies f...

Yuyi Yao, Xuesong Sun, Huageng Huang, Zhao Wang, **aojie Fang… in Radiation Oncology (2023)

Article

Transcription factor c-Jun modulates GLUT1 in glycolysis and breast cancer metastasis

As the main isoforms of membranous glucose transporters (GLUT), GLUT1 involves tumorigenesis, metastasis and prognosis in a variety of cancers. However, its role in breast cancer metastasis remains to be eluci...

** Zhu, Guo** Liu, Xue Wang, **g**g Lu, Yue Zhou, Shuyi Chen… in BMC Cancer (2022)

Article

Tumour inhibitory activity on pancreatic cancer by bispecific nanobody targeting PD-L1 and CXCR4

Antibodies and derivative drugs targeting immune checkpoints have been approved for the treatment of several malignancies, but there are fewer responses in patients with pancreatic cancer. Here, we designed a ...

Shuai Hao, Shuyi Xu, Liangzhu Li, Yaxian Li, Meiqi Zhao, Junsheng Chen… in BMC Cancer (2022)