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Article
Open AccessA novel CAF-cancer cell crosstalk-related gene prognostic index based on machine learning: prognostic significance and prediction of therapeutic response in head and neck squamous cell carcinoma
Cancer-associated fibroblast (CAF)-cancer cell crosstalk (CCCT) plays an important role in tumor microenvironment sha** and immunotherapy response. Current prognostic indexes are insufficient to accurately a...
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Article
Laboratory evaluation of high-friction thin overlays for pavement preservation
Traditional asphalt concrete (AC) and stone matrix asphalt (SMA), which are used as thin asphalt overlays, are common maintenance strategies to enhancing ride quality, skid resistance, and durability. Recently...
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Article
Fine map** and identification of a novel albino gene OsAL50 that is required for chlorophyll biosynthesis and chloroplast development in rice (Oryza sativa L.)
Leaf color is a highly important agronomic trait, and mutants with altered leaf coloration can serve as excellent models for studies on chloroplast development and chlorophyll biosynthesis, enabling the clonin...
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Article
Cerebral Hemodynamics Underlying Artery-to-Artery Embolism in Symptomatic Intracranial Atherosclerotic Disease
Artery-to-artery embolism (AAE) is a common stroke mechanism in intracranial atherosclerotic disease (ICAD), associated with a considerable risk of recurrent stroke. We aimed to investigate cerebral hemodynami...
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Article
Improving High-Temperature Mechanical Properties of Additively Manufactured Inconel 718 Through Heat Treatment
Post-heat treatments are vital to produce superior nickel-based superalloys with high performance by directed energy deposition (DED) for harsh service conditions. In this work, directed energy deposited Incon...
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Article
Carbon Emissions and Economic Cost of Different Collection, Storage, and Transportation Models for Crop Straw Off-Field Utilization
The off-field utilization of crop straw requires a highly efficient collection, storage, and transportation system, focusing on the synergistic optimization of efficiency, cost, and carbon emissions. Four typi...
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Article
Online mindfulness interventions for improving people’s mental health during the COVID-19 pandemic: a meta-analysis of randomized controlled trials
The COVID-19 pandemic has dramatically affected mental health, creating an urgent need for convenient and safe interventions to improve psychological distress. A comprehensive meta-analysis aims to systematica...
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Article
Open AccessTwelve newly assembled jasmine chloroplast genomes: unveiling genomic diversity, phylogenetic relationships and evolutionary patterns among Oleaceae and Jasminum species
Jasmine (Jasminum), renowned for its ornamental value and captivating fragrance, has given rise to numerous species and accessions. However, limited knowledge exists regarding the evolutionary relationships among...
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Article
Plasma neurofilament light as a promising biomarker in neuronal intranuclear inclusion disease
Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder lacking reliable biomarkers. This study investigates plasma protein levels as potential biomarkers of disease severity and pr...
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Article
Type I Interferon Signalling and Ischemic Stroke: Mechanisms and Therapeutic Potentials
Type I interferon (IFN-I) signalling is intricately involved in the pathogenesis of multiple infectious diseases, autoimmune diseases, and neurological diseases. Acute ischemic stroke provokes overactivation o...
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Article
Open AccessClinical features and associated factors of coexisting intracerebral hemorrhage in patients with cerebral small vessel disease: a cross-sectional study
Intracerebral hemorrhage (ICH) is generally considered to be closely related to cerebral small vessel disease (CSVD), leading to a poor prognosis. However, the coexistence of ICH in general CSVD patients and r...
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Article
Open AccessDetection of skin α-synuclein using RT-QuIC as a diagnostic biomarker for Parkinson’s disease in the Chinese population
Several studies have indicated that skin holds promise as a potential sample for detecting pathological α-Syn and serving as a diagnostic biomarker for α-synucleinopathies. Despite reports in Chinese PD patien...
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Article
Open AccessDynamic monitoring of UBA1 somatic mutations in patients with relapsing polychondritis
Commonly clinically diagnosed with relapsing polychondritis (RP), vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome (VEXAS) is a recently identified autoinflammatory disease caused by UBA1 somatic...
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Article
Classification of spin Hall effect in two-dimensional systems
Physical properties such as the conductivity are usually classified according to the symmetry of the underlying system using Neumann’s principle, which gives an upper bound for the number of independent compon...
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Article
Open AccessThe predictive value of uterine artery Doppler in the success rate of pregnancy from the first frozen embryo transfer during the implantation window
Worldwide, frozen embryo transfer (FET) has become a new strategy for the treatment of infertility. The success of FET is closely related to endometrial receptivity. Does uterine artery Doppler during the impl...
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Article
Bulk-boundary-transport correspondence of the second-order topological insulators
The bulk-boundary correspondence of the second-order topological insulator (SOTI) has been well established, but a universal transport signature for open systems is still absent. For a variety of SOTIs induced...
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Article
Occurrence, distribution and risk assessment of polycyclic aromatic hydrocarbons in soils around main water source areas of Bei**g, China
Polycyclic aromatic hydrocarbons (PAHs) in urban environments have been globally concerned due to their significant health impacts on residents. However, little is known about potential risks of PAHs from cent...
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Article
Neuroimaging markers of early neurological deterioration in acute isolated pontine infarction
Imaging indicators of early neurological deterioration (END) in patients with acute isolated pontine infarctions (AIPI) remained ambiguous. We aimed to find more specific neuroimaging markers for the developme...
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Article
A comprehensive study of clinicopathological and genetic features of neuronal intranuclear inclusion disease
The discovery of skin intranuclear inclusions and GGC repeat expansion of NOTCH2NLC has greatly promoted the diagnosis of neuronal intranuclear inclusion disease (NIID). With highly heterogeneous clinical manifes...
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Article
Open AccessShared metabolic shifts in endothelial cells in stroke and Alzheimer’s disease revealed by integrated analysis
Since metabolic dysregulation is a hallmark of both stroke and Alzheimer’s disease (AD), mining shared metabolic patterns in these diseases will help to identify their possible pathogenic mechanisms and potent...
