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Open AccessAuthor Correction: MC1R is dispensable for the proteinuria reducing and glomerular protective effect of melanocortin therapy
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessActivation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3β pathway signaling
Ecdysone is an arthropod molting hormone and has been marketed as a non-androgenic natural anabolic and adaptogen. However, the safety profile of ecdysone is largely undetermined. After ecdysone treatment for ...
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Open AccessRescue therapy with Tanshinone IIA hinders transition of acute kidney injury to chronic kidney disease via targeting GSK3β
Acute kidney injury (AKI) remains challenging for clinical practice and poses a risk of develo** progressive chronic kidney disease (CKD) with no definitive treatment available yet. Tanshinone IIA, an active...
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Open AccessActivation of FXR protects against renal fibrosis via suppressing Smad3 expression
Renal fibrosis is the common pathway of most chronic kidney disease progression to end-stage renal failure. The nuclear receptor FXR (farnesoid X receptor), a multiple functional transcription factor, plays an...
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Article
Open AccessA comparison of zircon U-Pb age results of the Red Clay sequence on the central Chinese Loess Plateau
Single grain zircon U-Pb geochronology has demonstrated great potentials in extracting tectonic and atmospheric circulation signal carried by aeolian, fluvial, and fluviolacustrine sediments. A routine in this...
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Open AccessMC1R is dispensable for the proteinuria reducing and glomerular protective effect of melanocortin therapy
Melanocortin therapy by using adrenocorticotropic hormone (ACTH) or non-steroidogenic melanocortin peptides attenuates proteinuria and glomerular injury in experimental glomerular diseases and induces remissio...
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Open AccessMagnetic fabric from Red clay sediments in the Chinese Loess Plateau
Well-distributed eolian red clay in a wide area of northern China is believed to imply the onset of an ancient East Asian monsoon system since Late Miocene. Two continuous red clay sequences spanning the time ...