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Article
Open AccessEarly-paleozoic rapakivi-textured granite from the North Qinling (Central China): implications for crust–mantle interactions in a post-collisional setting
Rapakivi granite is characterized by its unique structure, which has important implications for tectonic settings, magmatic processes, and crust–mantle interactions. In this study, we conducted a combined anal...
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Article
Open AccessLongshore changes in the microfacies and distribution of clastic barrier coastal sandbodies: a case from the Benxi formation in the Ordos Basin, China
The Benxi Formation in the Ordos Basin is an important gas-producing layer in the Yanchang gas field. There are critical changes in the microfacies type and extension trend of sandbodies, which affects the und...
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Article
Open AccessPermissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease
Renal tubular epithelial cells (TECs) play a key role in renal fibrogenesis. After persistent injuries that are beyond self-healing capacity, TECs will dedifferentiate, undergo growth arrest, convert to profib...
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Article
Melanocortin 5 receptor signaling pathway in health and disease
Melanocortin hormone system plays a key role in maintaining the homeostasis of our body via their neuro-immune-endocrine activities and regulates a diverse array of physiological functions, including melanogen...
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Article
Open AccessAuthor Correction: MC1R is dispensable for the proteinuria reducing and glomerular protective effect of melanocortin therapy
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Antibiotic resistance gene profiling in response to antibiotic usage and environmental factors in the surface water and groundwater of Honghu Lake, China
There is an increasing concern that aquaculture has been implicated in the formation of antibiotic resistance gene (ARG) reservoirs; however, little is known about the consequences of their presence in groundw...
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Article
Open AccessRNA-binding proteins tristetraprolin and human antigen R are novel modulators of podocyte injury in diabetic kidney disease
Diabetic kidney disease (DKD) is one of the most common complications of diabetes, and the most common cause of end-stage renal disease, for which no effective therapies are yet available. RNA-binding proteins...
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Article
Open AccessActivation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3β pathway signaling
Ecdysone is an arthropod molting hormone and has been marketed as a non-androgenic natural anabolic and adaptogen. However, the safety profile of ecdysone is largely undetermined. After ecdysone treatment for ...
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Article
Paleogene-Neogene stratigraphic realm and tectonic-sedimentary evolution of the Qilian Mountains and their surrounding areas
The Cenozoic uplift of Qilian Mountains is critical to comprehend the uplift and extension of the Tibet Plateau as well as the formation of the first and second steps in China’s topography. This study summariz...
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Article
Open AccessRescue therapy with Tanshinone IIA hinders transition of acute kidney injury to chronic kidney disease via targeting GSK3β
Acute kidney injury (AKI) remains challenging for clinical practice and poses a risk of develo** progressive chronic kidney disease (CKD) with no definitive treatment available yet. Tanshinone IIA, an active...
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Article
Open AccessActivation of FXR protects against renal fibrosis via suppressing Smad3 expression
Renal fibrosis is the common pathway of most chronic kidney disease progression to end-stage renal failure. The nuclear receptor FXR (farnesoid X receptor), a multiple functional transcription factor, plays an...
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Article
Open AccessA comparison of zircon U-Pb age results of the Red Clay sequence on the central Chinese Loess Plateau
Single grain zircon U-Pb geochronology has demonstrated great potentials in extracting tectonic and atmospheric circulation signal carried by aeolian, fluvial, and fluviolacustrine sediments. A routine in this...
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Article
Open AccessMC1R is dispensable for the proteinuria reducing and glomerular protective effect of melanocortin therapy
Melanocortin therapy by using adrenocorticotropic hormone (ACTH) or non-steroidogenic melanocortin peptides attenuates proteinuria and glomerular injury in experimental glomerular diseases and induces remissio...
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Article
Open AccessMagnetic fabric from Red clay sediments in the Chinese Loess Plateau
Well-distributed eolian red clay in a wide area of northern China is believed to imply the onset of an ancient East Asian monsoon system since Late Miocene. Two continuous red clay sequences spanning the time ...
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Article
The renaissance of corticotropin therapy in proteinuric nephropathies
Identification of effective therapies for nephrotic syndrome is challenging. The pituitary adrenocorticotropic hormone (ACTH) has been shown to be renoprotective in patients with proteinuric neuropathies, but ...
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Chapter and Conference Paper
On the Generalization of PAC-Bayes Bound for SVM Linear Classifier
PAC-Bayes theorem has been considered as a framework for deriving some of the tightest generalization bounds both for linear classifiers and stochastic classifiers. However, the generalization capability of PA...
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Chapter and Conference Paper
Comprehensive Mining on Medical Homepage Records Using Bayesian Network Approach
Hospitalizations today are confronted with increasing demand to ensure and improve the quality of care for patients. At present, many hospitals’ clinical databases have accumulated large quantities of informat...
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Chapter and Conference Paper
An Improved Algorithm for K-anonymity
K-anonymity is an important model that prevents joining attacks in privacy protecting. Many works have been conducted to achieve k-anonymity. OLA (Optimal Lattice Anonymization) is an efficient full-domain opt...
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Chapter and Conference Paper
A Probability Based Similarity Scoring for DNA Motifs Comparison
Comparing putative motifs is an important trail for the clustering of redundant motifs and map** motifs to transcription factors from previously characterized motif databases. Still, most existing methods co...
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Chapter and Conference Paper
MapCombine: A Lightweight Solution to Improve the Efficiency of Iterative MapReduce
MapReduce is a brilliant distributed computing strategy to process massive-scale data. However, for iterative applications, the general MapReduce needs to re-initialize runtime environment repetitively and re-...
