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Open AccessTREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson’s Disease Mice and LPS-Induced BV2 Cells
Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD). Triggering receptor expressed on myeloid cells 2 (TREM2) confers strong neuroprotective effects in PD ...
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Open AccessLncRNA landscape and associated ceRNA network in placental villus of unexplained recurrent spontaneous abortion
Unexplained recurrent spontaneous abortion (URSA) is one of the most challenging conditions frustrates women of childbearing age profoundly. The gene expression patterns and biological characteristics of place...
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Correction to: Identifying Parkinson’s disease with mild cognitive impairment by using combined MR imaging and electroencephalogram
A Correction to this paper has been published: https://doi.org/10.1007/s00330-021-07757-5
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Open AccessCorrection to: The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β‑catenin signaling
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Erratum to: In vivo and in situ real-time fluorescence imaging of peripheral nerves in the NIR-II window
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Correction to: Wormlike micelles formed by ultra‑long‑chain nonionic surfactant
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Open AccessBiochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway
Biotin is an essential micro-nutrient across the three domains of life. The paradigm earlier step of biotin synthesis denotes “BioC-BioH” pathway in Escherichia coli. Here we report that BioZ bypasses the canonic...
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Open AccessThe tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling
Zinc-finger protein 471 (ZNF471) is a member of the Krüppel-associated box domain zinc finger protein (KRAB-ZFP) family. ZNF471 is methylated in squamous cell carcinomas of tongue, stomach and esophageal. However...
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Article
Open AccessReconfigurable structured light generation in a multicore fibre amplifier
Structured light, with spatially varying phase or polarization distributions, has given rise to many novel applications in fields ranging from optical communication to laser-based material processing. However ...
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Open AccessInteraction variability shapes succession of synthetic microbial ecosystems
Cellular interactions are a major driver for the assembly and functioning of microbial communities. Their strengths are shown to be highly variable in nature; however, it is unclear how such variations regulat...
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Open AccessAction and mechanism of the colistin resistance enzyme MCR-4
Colistin is the last-resort antibiotic against lethal infections with multidrug-resistant bacterial pathogens. A rainbow coalition of mobile colistin resistance (mcr) genes raises global health concerns. Here, we...
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Open AccessDiscrimination of CRISPR/Cas9-induced mutants of rice seeds using near-infrared hyperspectral imaging
Identifying individuals with target mutant phenotypes is a significant procedure in mutant exploitation for implementing genome editing technology in a crop breeding programme. In the present study, a rapid an...
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Open AccessGenome characterization of two bile-isolated Vibrio fluvialis strains: an insight into pathogenicity and bile salt adaption
Vibrio fluvialis is recognized as an emerging pathogen. However, not much is known about the mechanism of its pathogenesis, and its adaptation to a special niche such as the gall bladder....
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Open AccessVirome analysis for identification of novel mammalian viruses in bats from Southeast China
Bats have been shown as important mammal resevoirs to carry a variety of zoonotic pathogens. To analyze pathogenic species in bats from southeast coastal regions of China, we performed metagenomic sequencing t...
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Open AccessExpanding landscapes of the diversified mcr-1-bearing plasmid reservoirs
Polymyxin is a cationic polypeptide antibiotic that can disrupt bacterial cell membrane by interacting with its lipopolysaccharide molecules and is used as a last resort drug against lethal infections by the c...
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Open AccessErratum to: Genome-wide analysis of an avirulent strain that induces protective immunity against challenge with virulent Streptococcus Suis serotype 2
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Open AccessGenetic Analysis of the IncX4 Plasmids: Implications for a Unique Pattern in the mcr-1 Acquisition
IncX4 plasmids are associated with the dissemination of the mcr-1 genes in Enterobacteriaceae. We screened IncX4 plasmids among 2,470 isolates of Enterobacteriaceae and determined the mcr-1 positive isolates. For...
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Open AccessGenome-wide analysis of a avirulent and reveal the strain induces pro-tective immunity against challenge with virulent Streptococcus suis Serotype 2
It was previously reported in China that two recent large-scale outbreaks of Streptococcus suis serotype 2 (S. suis 2) infections in human were caused by two highly virulent S. suis 2 strains, from which a novel ...
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Open AccessClonal spread of mcr-1 in PMQR-carrying ST34 Salmonella isolates from animals in China
Since initial identification in China, the widespread geographical occurrence of plasmid-mediated colistin resistance gene mcr-1 in Enterobacteriaceae has been of great concern. In this study, a total of 22 Salmo...
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Open AccessDiversified variants of the mcr-1-carrying plasmid reservoir in the swine lung microbiota