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Article
Combining satellite data and artificial intelligence with a crop growth model to enhance rice yield estimation and crop management practices
Rice is the staple food of more than half of the world’s population, especially in Asia, where rice provides more than 50% of the caloric supply for at least 520 million people, most of them are either extreme...
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Article
N-methyl-D-aspartate Receptor Subunits 2A and 2B Mediate Connexins and Pannexins in the Trigeminal Ganglion Involved in Orofacial Inflammatory Allodynia during Temporomandibular Joint Inflammation
Temporomandibular joint osteoarthritis (TMJOA) is a severe form of temporomandibular joint disorders (TMD), and orofacial inflammatory allodynia is one of its common symptoms which lacks effective treatment. N...
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Article
Green Hydrothermal Preparation of Ag-CP Nanocomposites with Lily Bulbs for Non-Enzymatic Glucose Detection
Green synthesis represents a superior strategy for mitigating the adverse effects of chemical synthesis on the environment. In particular, the utilization of bio-sourced materials for nanomaterial synthesis c...
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Article
Abnormal phosphorylation / dephosphorylation and Ca2+ dysfunction in heart failure
Heart failure (HF) can be caused by a variety of causes characterized by abnormal myocardial systole and diastole. Ca2+ current through the L-type calcium channel (LTCC) on the membrane is the initial trigger sig...
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Article
Open AccessNicotinate-curcumin improves NASH by inhibiting the AKR1B10/ACCα-mediated triglyceride synthesis
Nonalcoholic steatohepatitis (NASH) is a prevalent chronic liver condition. However, the potential therapeutic benefits and underlying mechanism of nicotinate-curcumin (NC) in the treatment of NASH remain unce...
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Article
Open AccessAsperuloside inhibits the activation of pancreatic cancer-associated fibroblasts via activating transcription factor 6
Pancreatic cancer-associated fibroblasts (CAFs) play a crucial role in tumor progression and immune evasion. Asperuloside (ASP) is an iridoid glycoside with potential anti-tumor properties. This study aimed to...
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Article
Open AccessAssociation analyses of apolipoprotein E genotypes and cognitive performance in patients with Parkinson’s disease
Cognitive impairment is a common non-motor symptom of Parkinson’s disease (PD). The apolipoprotein E (APOE) ε4 genotype increases the risk of Alzheimer’s disease (AD). However, the effect of APOEε4 on cognitiv...
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Article
Coupling Co2P nanoparticles onto N,P-doped biomass-derived carbon as efficient electrocatalysts for flexible Zn–air batteries
Catalysts for oxygen conversion play an important role in energy storage and conversion technologies such as metal–air batteries. Develo** highly active, stable, and low-cost catalysts is critical for furthe...
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Article
Dimerization and antidepressant recognition at noradrenaline transporter
The noradrenaline transporter has a pivotal role in regulating neurotransmitter balance and is crucial for normal physiology and neurobiology1. Dysfunction of noradrenaline transporter has been implicated in nume...
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Article
A review on vanadium extraction techniques from major vanadium-containing resources
The critical role of vanadium in metallurgy and the increasing commercialization of vanadium redox flow batteries have contributed to a rise in market demand for vanadium, emphasizing the need to ensure the su...
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Article
A computer-aided diagnosis system for breast pathology: a deep learning approach with model interpretability from pathological perspective
In this study, a computer-aided diagnosis (CAD) system for whole-slide images (WSIs) with breast cancer was proposed to achieve lesion detection and classification. Different from the previously proposed works...
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Article
Open AccessEnhancing intraneural revascularization following peripheral nerve injury through hypoxic Schwann-cell-derived exosomes: an insight into endothelial glycolysis
Endothelial cell (EC)-driven intraneural revascularization (INRV) and Schwann cells-derived exosomes (SCs-Exos) both play crucial roles in peripheral nerve injury (PNI). However, the interplay between them rem...
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Article
Early-onset and later-onset cancer: trends, risk factors, and prevention in Northern China
The characteristics of early-onset (onset age <50 years) and later-onset (onset age ≽ 50 years) cancers differ significantly. Identifying novel risk factors for both types of cancer is crucial for increasing a...
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Article
Surface engineering on MnO2 nanorods by La single atoms to accelerate oxygen reduction kinetics
Surface engineering, which modulates the electronic structure and adsorption/desorption properties of electrocatalysts, is one of the key strategies for improving the catalytic performance. Herein, we demonstr...
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Article
Open AccessAstrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice
Epigenetic mechanisms bridge genetic and environmental factors that contribute to the pathogenesis of major depression disorder (MDD). However, the cellular specificity and sensitivity of environmental stress ...
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Article
Four Labdane Diterpenoids from Leonurus japonicus
A new labdane diterpenoid, leojaponotin (1), and three known labdane diterpenoids (2–4), were isolated from Leonurus japonicus. Their structures were elucidated by spectroscopic analysis including NMR and MS.
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Article
RNA m6A methylation and regulatory proteins in pulmonary arterial hypertension
m6A (N6‑methyladenosine) is the most common and abundant apparent modification in mRNA of eukaryotes. The modification of m6A is regulated dynamically and reversibly by methyltransferase (writer), demethylase ...
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Article
Fabrication of a dual mimetic enzyme sensor based on gold nanoparticles modified with Cu(II)-coordinated methanobactin for gallic acid detection
Gallic acid (GA) is a bioactive functional ingredient widely used in pharmacology and food. For GA detection, the accuracy and selectivity can be improved from the enzyme based electrochemical sensor. However,...
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Article
Open AccessMETTL3-mediated deficiency of lncRNA HAR1A drives non-small cell lung cancer growth and metastasis by promoting ANXA2 stabilization
We previously reported lncRNA HAR1A as a tumor suppressor in non-small cell lung cancer (NSCLC). However, the delicate working mechanisms of this lncRNA remain obscure. Herein, we demonstrated that the ectopic ex...
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Article
P2X7 receptor is essential for ST36-attenuated cardiac fibrosis upon beta-adrenergic insult
P2X7 receptor (P2X7R) plays an important role in modulating inflammation and fibrosis, but information is limited whether Zusanli (ST36) can inhibit inflammation and fibrosis by regulating P2X7R. Isoprenaline ...
