84 Result(s)
within
**u-ling Li
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessLight-evoked deformations in rod photoreceptors, pigment epithelium and subretinal space revealed by prolonged and multilayered optoretinography
Phototransduction involves changes in concentration of ions and other solutes within photoreceptors and in subretinal space, which affect osmotic pressure and the associated water flow. Corresponding expansion...
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Open AccessAstrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice
Epigenetic mechanisms bridge genetic and environmental factors that contribute to the pathogenesis of major depression disorder (MDD). However, the cellular specificity and sensitivity of environmental stress ...
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Article
Open AccessRemnant cholesterol trajectory and subclinical arteriosclerosis: a 10-year longitudinal study of Chinese adults
We aimed to identify different trajectories of remnant cholesterol (RC) and investigate the association of RC trajectories with vascular endothelial function and atherosclerosis progression in a longitudinal c...
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Article
Open AccessNuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma
The MYC oncogene is often dysregulated in human cancer, including hepatocellular carcinoma (HCC). MYC is considered undruggable to date. Here, we comprehensively identify genes essential for survival of MYChigh b...
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Open AccessPrevalence and molecular characterization of Giardia duodenalis in dairy cattle in Central Inner Mongolia, Northern China
Giardia duodenalis is a gastrointestinal protozoan ubiquitous in nature. It is a confirmed zoonotic pathogen, and cattle are considered a source of giardiasis outbreaks in humans. This study aimed to evaluate the...
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Open AccessManipulating microRNA miR408 enhances both biomass yield and saccharification efficiency in poplar
The conversion of lignocellulosic feedstocks to fermentable sugar for biofuel production is inefficient, and most strategies to enhance efficiency directly target lignin biosynthesis, with associated negative ...
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Open AccessPrenatal DEHP exposure predicts neurological disorders via transgenerational epigenetics
Recent experimental and observational research has suggested that childhood allergic asthma and other conditions may be the result of prenatal exposure to environmental contaminants, such as di-(2-ethylhexyl) ...
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Open AccessCentral medial thalamic nucleus dynamically participates in acute itch sensation and chronic itch-induced anxiety-like behavior in male mice
Itch is an annoying sensation consisting of both sensory and emotional components. It is known to involve the parabrachial nucleus (PBN), but the following transmission nodes remain elusive. The present study ...
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Open AccessConserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells
Defining the mechanisms safeguarding cell fate identity in differentiated cells is crucial to improve 1) - our understanding of how differentiation is maintained in healthy tissues or altered in a disease stat...
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Open AccessAllele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia
Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine...
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Open AccessPilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma
PD-1 blockade (nivolumab) efficacy remains modest for metastatic sarcoma. In this paper, we present an open-label, non-randomized, non-comparative pilot study of bempegaldesleukin, a CD122-preferential interle...
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Open AccessDomain memory effect in the organic ferroics
Shape memory alloys have been used extensively in actuators, couplings, medical guide wires, and smart devices, because of their unique shape memory effect and superelasticity triggered by the reversible marte...
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Open AccessSelective feeding of three bivalve species on the phytoplankton community in a marine pond revealed by high-throughput sequencing
The study of the selective feeding of bivalves is necessary in order to improve our understanding of bivalve growth and development, which helps to better define the roles of bivalves in their ecosystems. Litt...
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Open AccessBroadly neutralizing antibodies target a haemagglutinin anchor epitope
Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus have the potential to provide near universal protection against influenza virus infection1. However, viral mutants tha...
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Open AccessDiabetic macular edema and proliferative diabetic retinopathy treated with anti-vascular endothelial growth factor under the reimbursement policy in Taiwan
The purpose of this retrospective interventional case series is to compare the functional and anatomical outcomes in eyes with diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) treated ...
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Open AccessRegulation of subsoiling tillage on the grain filling characteristics of maize varieties from different eras
Grain filling is the key stage for achieving high grain yield. Subsoiling tillage, as an effective conservation tillage, has been widely used in the maize planting region of China. This study was conducted to ...
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Open AccessAn efficient context-aware screening system for Alzheimer's disease based on neuropsychology test
Alzheimer's disease (AD) and other dementias have become the fifth leading cause of death worldwide. Accurate early detection of the disease and its precursor, Mild Cognitive Impairment (MCI), is crucial to al...
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Open AccessAuthor Correction: The effects of acarbose therapy on reductions of myocardial infarction and all-cause death in T2DM during 10-year multifactorial interventions (The Bei**g Community Diabetes Study 24)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessNeck circumference and waist circumference associated with cardiovascular events in type 2 diabetes (Bei**g Community Diabetes Study 23)
Obesity increases the risk of develo** cardiovascular disease and other metabolic diseases. We intended to compare three different anthropometric indicators of obesity, in predicting the incidence of cardiov...
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Open AccessPhiladelphia chromosome-negative B-cell acute lymphoblastic leukaemia with kinase fusions in Taiwan
Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukaemia (ALL), a high-risk subtype characterised by genomic alterations that activate cytokine receptor and kinase signalling, is associated with in...
