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Article
Oxidation resistant low-alloyed Ti alloys with good ductility
Oxidation resistance enhancement of pure Ti often comes at the cost of reduced ductility, which is frequently the problem through alloying with sole Al, Si, W, Mo and B. To overcome the short coming of single ...
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Article
Far-Infrared Therapy Based on Graphene Ameliorates High-Fat Diet-Induced Anxiety-Like Behavior in Obese Mice via Alleviating Intestinal Barrier Damage and Neuroinflammation
The consumption of a high-fat diet (HFD) has been implicated in the etiology of obesity and various neuropsychiatric disturbances, including anxiety and depression. Compelling evidence suggests that far-infrar...
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Article
Open AccessDistinct characteristics of the gut virome in patients with osteoarthritis and gouty arthritis
The gut microbiota and its metabolites play crucial roles in pathogenesis of arthritis, highlighting gut microbiota as a promising avenue for modulating autoimmunity. However, the characterization of the gut v...
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Article
Open AccessReal-time predictive model of extrauterine growth retardation in preterm infants with gestational age less than 32 weeks
The aim of this study was to develop a real-time risk prediction model for extrauterine growth retardation (EUGR). A total of 2514 very preterm infants were allocated into a training set and an external valida...
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Article
Electrolytes additives for Zn metal anodes: regulation mechanism and current perspectives
With distinct advantages such as high gravimetric and volumetric capacity (5855 mAh·cm−3 and 820 mAh·g−1), low redox potential (− 0.762 V vs. standard hydrogen electrode (SHE)), high abundance, low toxicity and i...
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Article
A Multilayer Dig-Limit Approach for Reducing Ore and Profit Losses in an Open-Pit Mine Having Complex Orebody
Rock fragment movement during blasting operations is a major cause of ore and profit losses in hard rock open-pit mines having a complex-orebody. To address this issue, a novel multilayer dig-limit approach, w...
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Article
Open AccessCLK2 mediates IκBα-independent early termination of NF-κB activation by inducing cytoplasmic redistribution and degradation
Activation of the NF-κB pathway is strictly regulated to prevent excessive inflammatory and immune responses. In a well-known negative feedback model, IκBα-dependent NF-κB termination is a delayed response pat...
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Article
Open AccessAn unexpected role of EasDaf: catalyzing the conversion of chanoclavine aldehyde to chanoclavine acid
Ergot alkaloids (EAs) are a diverse group of indole alkaloids known for their complex structures, significant pharmacological effects, and toxicity to plants. The biosynthesis of these compounds begins with ch...
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Article
Open AccessPretraining of attention-based deep learning potential model for molecular simulation
Machine learning-assisted modeling of the inter-atomic potential energy surface (PES) is revolutionizing the field of molecular simulation. With the accumulation of high-quality electronic structure data, a mo...
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Article
Cannabidiol Exerts Sedative and Hypnotic Effects in Normal and Insomnia Model Mice Through Activation of 5-HT1A Receptor
Cannabis sativa has been used for improving sleep for long history. Cannabidiol (CBD) has drown much attention as a non-addictive psychoactive component in Cannabis sativa extract. However, the effects of CBD on...
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Article
Open AccessActivation of CTU2 expression by LXR promotes the development of hepatocellular carcinoma
Cytosolic thiouridylase 2 (CTU2) is an enzyme modifying transfer RNAs post-transcriptionally, which has been implicated in breast cancer and melanoma development. And we found CTU2 participated in hepatocellul...
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Article
Open AccessNADPH oxidase 2 mediates cardiac sympathetic denervation and myocyte autophagy, resulting in cardiac atrophy and dysfunction in doxorubicin-induced cardiomyopathy
Doxorubicin has been used extensively as a potent anticancer agent, but its clinical use is limited by its cardiotoxicity. However, the underlying mechanisms remain to be fully elucidated. In this study, we te...
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Open AccessCompounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others
In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1–12), a triterpene (15), and two other compounds (13, 14) were isolated from the woods of Agathis dammara. The structure of the new c...
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Article
Open AccessThe role of nutrition in analysis of risk factors and short-term outcomes for late-onset necrotizing enterocolitis among very preterm infants: a nationwide, multicenter study in China
Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease, primarily affects preterm newborns and occurs after 7 days of life (late-onset NEC, LO-NEC). Unfortunately, over the past several decades,...
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Article
Characterization of CM-Dil-labeled Muse cells in culture and in skin wounds in rats
To investigate the characteristics of multilineage-differentiating stress-enduring (Muse) cells labeled with chloromethyl dialkylcarbocyanine (CM-Dil) in culture and in skin wounds of rats. Normal human dermal...
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Article
Open AccessAddendum: Cellular differentiation into hyphae and spores in halophilic archaea
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Article
Retraction Note: Zn(II)-Containing Metal–Organic Framework for Fluorescence Detection of Nitrobenzene and Prevention Effect on Hypertension via Down-Regulating the Expression of Vitamin D Receptor
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Article
Open AccessElectron scale coherent structure as micro accelerator in the Earth’s magnetosheath
Turbulent energy dissipation is a fundamental process in plasma physics that has not been settled. It is generally believed that the turbulent energy is dissipated at electron scales leading to electron energi...
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Article
Open AccessEfficacy of Qingpeng ointment (a Tibetan medicine) for acute gouty arthritis: a multi-center, randomized, double-blind, placebo-controlled trial
This study aims to assess the efficacy and safety of Qingpeng ointment (QPO), a Tibetan medicine for alleviating symptoms in individuals with acute gouty arthritis (AGA).
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Article
Open AccessA publicly available newborn ear shape dataset for medical diagnosis of auricular deformities
Early and accurate diagnosis of ear deformities in newborns is crucial for an effective non-surgical correction treatment, since this commonly seen ear anomalies would affect aesthetics and cause mental proble...
