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Article
Transformation of A1/A2 Astrocytes Participates in Brain Ischemic Tolerance Induced by Cerebral Ischemic Preconditioning via Inhibiting NDRG2
Cerebral ischemic preconditioning (CIP) has been shown to improve brain ischemic tolerance against subsequent lethal ischemia. Reactive astrocytes play important roles in cerebral ischemia–reperfusion. Recent ...
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Article
Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction
Cardiac fibrosis is a pathological scarring process that impairs cardiac function. N-acetyltransferase 10 (Nat10) is recently identified as the key enzyme for the N4-acetylcytidine (ac4C) modification of mRNAs...
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Article
Open AccessCorrection: Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease
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Article
Open AccessSusceptibility gene identification and risk evaluation model construction by transcriptome-wide association analysis for salt sensitivity of blood pressure
Salt sensitivity of blood pressure (SSBP) is an intermediate phenotype of hypertension and is a predictor of long-term cardiovascular events and death. However, the genetic structures of SSBP are uncertain, an...
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Article
Kv3.1 Interaction with UBR5 Is Required for Chronic Inflammatory Pain
Chronic inflammatory pain caused by neuronal hyperactivity is a common and refractory disease. Kv3.1, a member of the Kv3 family of voltage-dependent K+ channels, is a major determinant of the ability of neurons ...
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Article
Open AccessThe effects of Elgucare in a rat model of intervertebral disc degeneration
As an avascular tissue, the intervertebral disc (IVD) faces difficulties in obtaining nutrients and is prone to accumulating metabolic waste. The ensuing IVD degeneration (IVDD) causes symptoms such as low bac...
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Article
Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells
Telomere repeat binding factor 2 (TRF2), a critical element of the shelterin complex, plays a vital role in the maintenance of genome integrity. TRF2 overexpression is found in a wide range of malignant cancer...
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Article
Open AccessPD-1/CD80+ small extracellular vesicles from immunocytes induce cold tumours featured with enhanced adaptive immunosuppression
Only a minority of cancer patients benefit from immune checkpoint blockade therapy. Sophisticated cross-talk among different immune checkpoint pathways as well as interaction pattern of immune checkpoint molec...
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Article
Evaluation of the Efficacy of Stem Cells Therapy in the Periodontal Regeneration: A Meta-Analysis and Mendelian Randomization Study
Stem cell therapy for periodontal defects has shown good promise in preclinical studies. The purpose of this study was to evaluate the impact of stem cell support on the regeneration of both soft and hard tiss...
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Article
Controllable Ring-opening Polymerization of δ-Valerolactone Catalyzed by Quinolinyl-Urea/MTBD Systems
Due to their excellent biocompatibility and biodegradability, aliphatic polyesters are widely used in the biomedical, packaging and agricultural fields, which are usually accessed by the ring-opening polymeriz...
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Article
Open AccessAnalyzing genetic diversity in luffa and develo** a Fusarium wilt-susceptible linked SNP marker through a single plant genome-wide association (sp-GWAS) study
Luffa (Luffa spp.) is an economically important crop of the Cucurbitaceae family, commonly known as sponge gourd or vegetable gourd. It is an annual cross-pollinated crop primarily found in the subtropical and tr...
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Article
Comparison of thermal shock resistance capabilities of the rotary swaged pure tungsten, potassium-doped tungsten, and W-La2O3 alloys
Tungsten-based materials are one of the most important candidates for the plasma facing materials (PFMs) of future fusion reactors, and it is necessary to study the properties of tungsten-based materials under...
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Article
Phosphorus additives driving the bacterial community succession during Bacillus spp. remediation of the uranium tailings
Uranium tailings discharged into uranium tailings ponds could generate environmental pollution issues. Microbial-induced phosphate mineralization could reduce the release of uranium, in turn effectively managi...
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Article
STAT4-Mediated Klotho Up-Regulation Contributes to the Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning via Inhibiting Neuronal Pyroptosis
Our previous study has proved that the Klotho up-regulation participated in cerebral ischemic preconditioning (CIP)-induced brain ischemic tolerance. However, the exact neuroprotective mechanism of Klotho in C...
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Article
The Role of Astrocytic Mitochondria in the Pathogenesis of Brain Ischemia
The morbidity rate of ischemic stroke is increasing annually with the growing aging population in China. Astrocytes are ubiquitous glial cells in the brain and play a crucial role in supporting neuronal functi...
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Article
Open AccessCorrection: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses
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Article
Construction and validation of a risk-prediction model for chemotherapy-related cognitive impairment in patients with breast cancer
To identify risk factors of chemotherapy-related cognitive impairment (CRCI) and construct and validate a visual prediction model of such for patients with breast cancer.
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Article
Open AccessHeart-brain axis: low blood pressure during off-pump CABG surgery is associated with postoperative heart failure
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Article
Open AccessFlexible and wearable battery-free backscatter wireless communication system for colour imaging
Wireless imaging, equipped with ultralow power wireless communications and energy harvesting (EH) capabilities, have emerged as battery-free and sustainable solutions. However, the challenge of implementing wi...
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Article
Open AccessCurriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review
RNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-binding domains (RBDs), and they can assembly into ribonucleic acid–protein complexes, which mediate transportation, editi...
