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Tinnitus reduction after active bone-conduction implantation in patients with single-sided deafness: a prospective multicenter study
Single-sided deafness (SSD) presents significant challenges for patients, including compromised sound localization, reduced speech recognition, and often, tinnitus. These issues are typically addressed using i...
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Article
Open AccessNovel role of LLGL2 silencing in autophagy: reversing epithelial-mesenchymal transition in prostate cancer
Prostate cancer (PCa) is a major urological disease that is associated with significant morbidity and mortality in men. LLGL2 is the mammalian homolog of Lgl. It acts as a tumor suppressor in breast and hepati...
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Article
Open AccessFlexible and wearable battery-free backscatter wireless communication system for colour imaging
Wireless imaging, equipped with ultralow power wireless communications and energy harvesting (EH) capabilities, have emerged as battery-free and sustainable solutions. However, the challenge of implementing wi...
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Open AccessInhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD
There is an intrinsic relationship between psychiatric disorders and neuroinflammation, including bipolar disorder. Ouabain, an inhibitor of Na+/K+-ATPase, has been implicated in the mouse model with manic-like b...
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Article
Open AccessCirrhotic-extracellular matrix attenuates aPD-1 treatment response by initiating immunosuppressive neutrophil extracellular traps formation in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is closely associatedwith chronic liver diseases, particularly liver cirrhosis, which has an altered extracellular matrix (ECM) composition. The influence and its mechanism of th...
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Article
Mechanical deterioration effect and damage evolution characteristics of soft sandstone with different water-immersed heights under uniaxial compression
Soft sandstones are known to deteriorate with increasing water saturation. This study explores the effects of different immersion heights on the failure characteristics of soft sandstone obtained from the seco...
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Article
Open AccessA lesion-selective albumin-CTLA4Ig as a safe and effective treatment for collagen-induced arthritis
CTLA4Ig is a dimeric fusion protein of the extracellular domain of cytotoxic T-lymphocyte protein 4 (CTLA4) and an Fc (Ig) fragment of human IgG1 that is approved for treating rheumatoid arthritis. However, CTLA4...
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Article
Open AccessStretchable and self-healable spoof plasmonic meta-waveguide for wearable wireless communication system
Microwave transmission lines in wearable systems are easily damaged after frequent mechanical deformation, posing a severe threat to wireless communication. Here, we report a new strategy to achieve stretchabl...
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Article
Open AccessCorrelation between loneliness, personality traits, and treatment outcomes in patients with methamphetamine use disorder
The aim of this study was to investigate whether loneliness and personality traits correlate with the treatment outcome of methamphetamine use disorder. In this 1-year longitudinal study, a total 106 participa...
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Article
Open AccessLoneliness and isolated living status in middle-aged and older adults in Taiwan: exploration on stress-related biomarkers, depressive symptoms, and disability
Loneliness is a subjective feeling by which an individual perceives a lack of closeness in interpersonal relationships. An isolated living status is linked with higher odds of risky health behavior. The confli...
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Article
The circRNA CNEACR regulates necroptosis of cardiomyocytes through Foxa2 suppression
Circular RNAs (circRNAs) are differentially expressed in various cardiovascular disease including myocardial ischemia-reperfusion (I/R) injury. However, their functional impact on cardiomyocyte cell death, in ...
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Article
Open AccessMultifunctional carbonized nanogels to treat lethal acute hepatopancreatic necrosis disease
Shrimp aquaculture has suffered huge economic losses over the past decade due to the outbreak of acute hepatopancreatic necrosis disease (AHPND), which is mainly caused by the bacteria Vibrio parahaemolyticus (V....
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Article
Open AccessStaged transverse preputial island flap urethroplasty for some proximal hypospadias with moderate-to-severe chordee
We aimed to assess the outcome of staged transverse preputial island flap (TPIF) urethroplasty for repairing certain cases of primary proximal hypospadias with moderate-to-severe chordee in children.
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Article
Open AccessThe effects of traffic-related air pollutants on chronic obstructive pulmonary disease in the community-based general population
Previous studies have shown inconsistent results regarding the impact of traffic pollution on the prevalence of chronic obstructive pulmonary disease (COPD). Therefore, using frequency matching and propensity ...
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Article
Open AccessWolfberry genomes and the evolution of Lycium (Solanaceae)
Wolfberry Lycium, an economically important genus of the Solanaceae family, contains approximately 80 species and shows a fragmented distribution pattern among the Northern and Southern Hemispheres. Although seve...
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Article
Open AccessApplication of the screening and indirect cohort methods to evaluate the effectiveness of pneumococcal vaccination program in adults 75 years and older in Taiwan
The Taiwanese national 23-valent pneumococcal polysaccharide vaccine (PPV23) program in adults ≥75 years of age and the 13-valent pneumococcal conjugate vaccine (PCV13) program for children were implemented in...
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Article
Open AccessDouble attack strategy for leukemia using a pre-targeting bispecific antibody (CD20 Ab-mPEG scFv) and actively attracting PEGylated liposomal doxorubicin to enhance anti-tumor activity
Tumor-targeted nanoparticles hold great promise as new tools for therapy of liquid cancers. Furthermore, the therapeutic efficacy of nanoparticles can be improved by enhancing the cancer cellular internalization.
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Book and Conference Proceedings
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Article
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA
PIWI-interacting RNAs (piRNAs) are abundantly expressed during cardiac hypertrophy. However, their functions and molecular mechanisms remain unknown. Here, we identified a cardiac-hypertrophy-associated piRNA ...
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Article
Open AccessChemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline (updated version)
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the ...
