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  1. Article

    Open Access

    Ca2+ channel blockade reduces cocaine’s vasoconstriction and neurotoxicity in the prefrontal cortex

    Cocaine profoundly affects both cerebral blood vessels and neuronal activity in the brain. The vasoconstrictive effects of cocaine, concurrently with its effects on neuronal [Ca2+]i accumulation are likely to jeo...

    Congwu Du, Kicheon Park, Craig P. Allen, **u-Ti Hu… in Translational Psychiatry (2021)

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  2. No Access

    Article

    Aging alters voltage-gated calcium channels in prefrontal cortex pyramidal neurons in the HIV brain

    We assessed firing and voltage-gated Ca2+ influx in medial prefrontal cortex (mPFC) pyramidal neurons from older (12 months old) HIV-1 transgenic (Tg) rats. We found that neurons from older Tg rats showed increas...

    Christina E. Khodr, Lihua Chen, Lena Al-Harthi, **u-Ti Hu in Journal of NeuroVirology (2018)

  3. No Access

    Article

    Thermal flow air post-treatment under high relative humidity for efficient and reproducible planar CH3NH3PbI3−xClx based perovskite solar cells

    We report the effects of thermal flow air post-treatment on the performance of solution-processed CH3NH3PbI3−xClx based planar solar cells under high relative humidity. It is found that the treatment process resu...

    Chong-Zhen Zhang, Shu-Ti Li, Miao He, Song-Yang Yuan… in Optical and Quantum Electronics (2016)

  4. Article

    HIV-1 Transgenic Rat Prefrontal Cortex Hyper-Excitability is Enhanced by Cocaine Self-Administration

    The medial prefrontal cortex (mPFC) is dysregulated in HIV-1-infected humans and the dysregulation is enhanced by cocaine abuse. Understanding mPFC pathophysiology in this comorbid state has been hampered by t...

    Wesley N Wayman, Lihua Chen, **u-Ti Hu, T Celeste Napier in Neuropsychopharmacology (2016)

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  5. No Access

    Article

    Repeated Cocaine Treatment Enhances HIV-1 Tat-induced Cortical Excitability via Over-activation of L-type Calcium Channels

    The prefrontal cortex (PFC) is dysregulated in neuroAIDS and during cocaine abuse. Repeated cocaine treatment upregulates voltage gated L-type Ca2+ channels in pyramidal neurons within the rat medial PFC (mPFC). ...

    T. Celeste Napier, Lihua Chen, Fatah Kashanchi… in Journal of Neuroimmune Pharmacology (2014)

  6. No Access

    Article

    Methamphetamine and HIV-1 Tat Down Regulate β-catenin Signaling: Implications for Methampetamine Abuse and HIV-1 Co-morbidity

    Methamphetamine (Meth) abuse exacerbates HIV-1-associated neurocognitive disorders (HAND). The underlying mechanism for this effect is not entirely clear but likely involves cooperation between Meth and HIV-1 ...

    Amit Sharma, **u-Ti Hu, T. Celeste Napier… in Journal of Neuroimmune Pharmacology (2011)

  7. No Access

    Article

    Inhibition of neuronal nitric oxide synthase prevents alterations in medial prefrontal cortex excitability induced by repeated cocaine administration

    The medial prefrontal cortex (mPFC), a forebrain region that regulates cognitive function and reward-motivated behaviors, has been implicated in the neuropathological mechanisms of drug addiction and withdrawa...

    Fernando J. Nasif, **u-Ti Hu, Oscar A. Ramirez, Mariela F. Perez in Psychopharmacology (2011)

  8. No Access

    Article

    Cocaine withdrawal and neuro-adaptations in ion channel function

    Chronic exposure to psychostimulants induces neuro-adaptations in ion channel function of dopamine (DA)-innervated cells localized within the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc). Althou...

    **u-Ti Hu in Molecular Neurobiology (2007)

  9. Article

    Repeated Cocaine Administration Decreases Calcineurin (PP2B) but Enhances DARPP-32 Modulation of Sodium Currents in Rat Nucleus Accumbens Neurons

    Our previous studies have demonstrated that repeated cocaine (COC) administration reduces voltage-sensitive sodium and calcium currents (INa or VSSCs and ICa or VSCCs, respectively) in medium spiny nucleus accumb...

    **u-Ti Hu, Kerstin Ford, Francis J White in Neuropsychopharmacology (2005)

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  10. No Access

    Article

    Two-way shape memory effect of TiNi alloys induced by hydrogenation

    An investigation on the two-way shape memory effect (TWSME) induced by an electrochemical hydrogenation has been conducted on two TiNi shape memory alloys (SMAs) (Ti49.2Ni50.8 and Ti51.1Ni48.9 denoted as material...

    Ching-Chich Leu, David Vokoun, Chen-Ti Hu in Metallurgical and Materials Transactions A (2002)

  11. No Access

    Article

    Loss of autoreceptor functions in mice lacking the dopamine transporter

    Autoreceptors provide an important inhibitory feedback mechanism for dopamine neurons by altering neuronal functions in response to changes in extracellular levels of dopamine. Elevated dopamine may be a compo...

    Sara R. Jones, Raul R. Gainetdinov, **u-Ti Hu, Donald C. Cooper… in Nature Neuroscience (1999)

  12. Article

    Dopamine Receptor Antagonists Fail to Prevent Induction of Cocaine Sensitization

    We investigated the ability of dopamine D1 and D2 class receptor antagonists to prevent the induction of behavioral sensitization to cocaine. The D2 receptor antagonist eticlopride failed to prevent the induction...

    Francis J White Ph.D, Amit Joshi MD, Timothy E Koeltzow BA… in Neuropsychopharmacology (1998)

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  13. No Access

    Article

    Clinical significance of multiple hypothalamic-pituitary functions assessment in patients with Turner’s syndrome

    Hypothalamic-pituitary functions in 26 cases of Turner syndrome were assessed with a combined stimulation test. The results showed that the peak GH levels of 12 cases were less than 10 μg/L; 3 patients were de...

    Ning Cong, Wei Hong, Shu Dan, Hu **ao-feng… in Journal of Tongji Medical University (1994)

  14. No Access

    Chapter

    Interactions between Cholecystokinin and Dopamine: Electrophysiological Studies

    Cholecystokinin (CCK), a peptide hormone found originally in the pancreas and gastrointestinal tract, has now been demonstrated to exist in high concentration in various areas of the central nervous system (CN...

    Rex Y. Wang, **u-Ti Hu, Richard J. Kasser in Pharmacology and Functional Regulation of … (1988)