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  1. Article

    Open Access

    Counterion docking: a general approach to reducing energetic disorder in doped polymeric semiconductors

    Molecular do** plays an important role in controlling the carrier concentration of organic semiconductors. However, the introduction of dopant counterions often results in increased energetic disorder and tr...

    Miao **ong, **n-Yu Deng, Shuang-Yan Tian, Kai-Kai Liu, Yu-Hui Fang in Nature Communications (2024)

  2. Article

    Open Access

    Long-term complications and outcomes of augmentation cystoplasty in children with neurogenic bladder

    Augmentation cystoplasty (AC) is an effective surgical procedure for patients with neurogenic bladder whenever conservative treatments have failed. The present study aimed to determine the risks of metabolic c...

    Jei-Wen Chang, Fang-Cheng Kuo, Tzu-Ching Lin, Tai-Wai Chin in Scientific Reports (2024)

  3. Article

    Open Access

    Pick-up single-cell proteomic analysis for quantifying up to 3000 proteins in a Mammalian cell

    The shotgun proteomic analysis is currently the most promising single-cell protein sequencing technology, however its identification level of ~1000 proteins per cell is still insufficient for practical applica...

    Yu Wang, Zhi-Ying Guan, Shao-Wen Shi, Yi-Rong Jiang, Jie Zhang in Nature Communications (2024)

  4. Article

    Open Access

    Camrelizumab and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma: a phase 2 clinical trial

    The antiangiogenic agent apatinib has been shown to clinically improve responses to immune checkpoint inhibitors in several cancer types. Patients with N3 nasopharyngeal carcinoma have a high risk of distant m...

    Hu Liang, Yao-Fei Jiang, Guo-Ying Liu, Lin Wang, Jian-Wei Wang in Nature Communications (2024)

  5. Article

    Open Access

    Serum IGFBP-1 as a promising diagnostic and prognostic biomarker for colorectal cancer

    Our previous study showed that levels of circulating insulin-like growth factor binding protein-1 (IGFBP-1) has potential diagnostic value for early-stage upper gastrointestinal cancers. This study aimed to as...

    Bin-Liang Huang, Lai-Feng Wei, Yi-Wei Lin, Li-Sheng Huang, Qi-Qi Qu in Scientific Reports (2024)

  6. Article

    Open Access

    Ubiquitination-mediated Golgi-to-endosome sorting determines the toxin-antidote duality of fission yeast wtf meiotic drivers

    Killer meiotic drivers (KMDs) skew allele transmission in their favor by killing meiotic progeny not inheriting the driver allele. Despite their widespread presence in eukaryotes, the molecular mechanisms behi...

    **-**n Zheng, Tong-Yang Du, Guang-Can Shao, Zhu-Hui Ma in Nature Communications (2023)

  7. Article

    Open Access

    Proteomic characterization of epithelial ovarian cancer delineates molecular signatures and therapeutic targets in distinct histological subtypes

    Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear....

    Ting-Ting Gong, Shuang Guo, Fang-Hua Liu, Yun-Long Huo, Meng Zhang in Nature Communications (2023)

  8. Article

    Open Access

    Actinide-lanthanide single electron metal-metal bond formed in mixed-valence di-metallofullerenes

    Understanding metal-metal bonding involving f-block elements has been a challenging goal in chemistry. Here we report a series of mixed-valence di-metallofullerenes, ThDy@C2n (2n = 72, 76, 78, and 80) and ThY@C2n

    Ying**g Yan, Laura Abella, Rong Sun, Yu-Hui Fang, Yannick Roselló in Nature Communications (2023)

  9. Article

    Open Access

    Screening of single nucleotide polymorphisms within HLA region related to hematopoietic stem cell transplantation using MassARRAY technology

    A growing number of studies showed that single nucleotide polymorphisms (SNPs) in the human leukocyte antigen (HLA)-related genes were associated with the outcome of hematopoietic stem cell transplantation (HS...

    Shu-Hui Tsai, Pi-Yueh Chang, Ying-Hao Wen, Wei-Tzu Lin, Fang-** Hsu in Scientific Reports (2023)

  10. Article

    Open Access

    Contribution of tree community structure to forest productivity across a thermal gradient in eastern Asia

    Despite their fundamental importance the links between forest productivity, diversity and climate remain contentious. We consider whether variation in productivity across climates reflects adjustment among tre...

    Tetsuo I. Kohyama, Douglas Sheil, I-Fang Sun, Kaoru Niiyama in Nature Communications (2023)

  11. Article

    Open Access

    Obstructive sleep apnea in young Asian adults with sleep-related complaints

    This study aimed to investigate the proportion of young OSA adults with sleep-related complaints in a sleep center, affiliated with a tertiary medical center for over a decade. This study presents a chronicle ...

    Hwa-Yen Chiu, Kun-Ta Chou, Kang-Cheng Su, Fang-Chi Lin, Yung-Yang Liu in Scientific Reports (2022)

  12. Article

    Open Access

    A comprehensive evaluation of COVID-19 policies and outcomes in 50 countries and territories

    The COVID-19 pandemic struck the world unguarded, some places outperformed others in COVID-19 containment. This longitudinal study considered a comparative evaluation of COVID-19 containment across 50 distinct...

    Hsiao-Hui Tsou, Shu-Chen Kuo, Yu-Hsuan Lin, Chao A. Hsiung in Scientific Reports (2022)

  13. Article

    Open Access

    High-mobility semiconducting polymers with different spin ground states

    Organic semiconductors with high-spin ground states are fascinating because they could enable fundamental understanding on the spin-related phenomenon in light element and provide opportunities for organic mag...

    **ao-**ang Chen, Jia-Tong Li, Yu-Hui Fang, **n-Yu Deng in Nature Communications (2022)

  14. Article

    Open Access

    The interaction between self-care behavior and disease knowledge on the decline in renal function in chronic kidney disease

    Multidisciplinary care can improve the outcomes of chronic kidney disease (CKD), however the contribution of self-care behavior and knowledge about CKD is unclear. This study enrolled 454 participants with CKD...

    Yi-Chun Tsai, Shu-Li Wang, Hui-Ju Tsai, Tzu-Hui Chen, Lan-Fang Kung in Scientific Reports (2021)

  15. Article

    Open Access

    A randomized feasibility study of the effect of ascorbic acid on post-angioplasty restenosis of hemodialysis vascular access (NCT03524846)

    Restenosis remains a significant problem after angioplasty of hemodialysis vascular access. Both experimental and clinical studies have shown a protective effect of antioxidants against post-angioplasty resten...

    Chung-Wei Yang, Chih-Cheng Wu, Chien-Ming Luo, Shao-Yuan Chuang in Scientific Reports (2019)

  16. Article

    Open Access

    Chemopreventive Effect of Phytosomal Curcumin on Hepatitis B Virus-Related Hepatocellular Carcinoma in A Transgenic Mouse Model

    Chronic hepatitis B virus (HBV) infection is a major risk factor for the development of hepatocellular carcinoma (HCC), a leading cause of cancer mortality worldwide. Hepatitis B X protein (HBx) and pre-S2 mut...

    Chiao-Fang Teng, Chun-Hui Yu, Hong-Yi Chang, Wen-Chuan Hsieh in Scientific Reports (2019)

  17. Article

    Open Access

    A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter

    The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent provir...

    Jun Wu, Ming-tao Ao, Rui Shao, Hui-ru Wang, Diao Yu, Mei-juan Fang in Scientific Reports (2017)

  18. Article

    Open Access

    Machine Learning Algorithms for Risk Prediction of Severe Hand-Foot-Mouth Disease in Children

    The identification of indicators for severe HFMD is critical for early prevention and control of the disease. With this goal in mind, 185 severe and 345 mild HFMD cases were assessed. Patient demographics, cli...

    Bin Zhang, **ang Wan, Fu-sheng Ouyang, Yu-hao Dong, De-hui Luo in Scientific Reports (2017)

  19. Article

    Open Access

    Low level of swiprosin-1/EFhd2 in vestibular nuclei of spontaneously hypersensitive motion sickness mice

    Susceptibility to motion sickness (MS) varies considerably among humans. However, the cause of such variation is unclear. Here, we used a classical genetic approach to obtain mouse strains highly sensitive and...

    Zhi-Bin Wang, ** Han, Ling-Chang Tong, Yi Luo, Wei-Heng Su, **n Wei in Scientific Reports (2017)

  20. Article

    Open Access

    The efficacy of semi-quantitative urine protein-to-creatinine (P/C) ratio for the detection of significant proteinuria in urine specimens in health screening settings

    Urine protein detection could be underestimated using the conventional dipstick method because of variations in urine aliquots. This study aimed to assess the efficacy of the semi-quantitative urine protein-t...

    Chih-Chun Chang, Ming-Jang Su, Jung-Li Ho, Yu-Hui Tsai, Wei-Ting Tsai in SpringerPlus (2016)

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