5,204 Result(s)
within
**u** Guo
Biochemistry, general
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Article
METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis
Numerous studies have indicated that N6-methyladenosine (m6A) and lncRNAs play pivotal roles in human cancer. However, the underlying functions and mechanisms of m6A-lncRNA in the physiological processes of breas...
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Preparation of (S)-epichlorohydrin using a novel halohydrin dehalogenase by selective conformation adjustment
Chiral epichlorohydrin (ECH) is an attractive intermediate for chiral pharmaceuticals and chemicals preparation. The asymmetric synthesis of chiral ECH using 1,3-dicholoro-2-propanol (1,3-DCP) catalyzed by a h...
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Article
Activation of MAL2 by RAD21 inhibits the expression of MHC-I in immune evasion of endometrial cancer
CD8+ T cells are the primary mediators of anticancer immunity, and modulation of the CD8+ T cell response has been a central focus of immunotherapy to treat cancer. When CD8+ T cells specifically recognize antige...
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Phosphodiesterase 8 (PDE8): Distribution and Cellular Expression and Association with Alzheimer’s Disease
Phosphodiesterase 8 (PDE8), as a member of PDE superfamily, specifically promotes the hydrolysis and degradation of intracellular cyclic adenosine monophosphate (cAMP), which may be associated with pathogenesi...
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Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer’s Disease
Neuroinflammation and endothelial cell apoptosis are prominent features of blood–brain barrier (BBB) disruption, which have been described in Alzheimer’s disease (AD) and can predict cognitive decline. Recent ...
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Article
Open AccessIntegrated transcriptomics and metabolomics provide insights into the biosynthesis of militarine in the cell suspension culture system of Bletilla striata
Militarine is a monomer molecule with abundant and distinctive biological properties, also the lead member of secondary metabolites in Bletilla striata, while its biosynthesis mechanism is still unknown. To impro...
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Article
Open AccessExploring the challenges of RNAi-based strategies for crop protection
RNA silencing (or RNA interference, RNAi) initiated by double-stranded RNAs is a conserved mechanism for regulating gene expression in eukaryotes. RNAi-based crop protection strategies, including host-induced ...
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Article
Regulation of oxidative stress response and antioxidant modification in Corynebacterium glutamicum
As an efficient and safe industrial bacterium, Corynebacterium glutamicum has extensive application in amino acid production. However, it often faces oxidative stress induced by reactive oxygen species (ROS), lea...
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Article
Open AccessPhenotypic characterization and gene map** of hybrid necrosis in Triticum durum–Haynaldia villosa amphiploids
Phenotypical, physiological and genetic characterization was carried out on the hybrid necrosis gene from Haynaldia villosa, and the related gene Ne-V was mapped to chromosome arm 2VL.
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Article
Open AccessTruncated tau interferes with the autophagy and endolysosomal pathway and results in lipid accumulation
The autophagy-lysosomal pathway plays a critical role in the clearance of tau protein aggregates that deposit in the brain in tauopathies, and defects in this system are associated with disease pathogenesis. H...
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Article
Open AccessHMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage
Drug-induced organic damage encompasses various intricate mechanisms, wherein HMGB1, a non-histone chromosome-binding protein, assumes a significant role as a pivotal hub gene. The regulatory functions of HMGB...
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Article
Polydimethylsiloxane-Assisted Surface Plasmon Resonance–Based Temperature Sensor
Since the important applications in multiple fields, research on temperature sensors based on surface plasmon resonance (SPR) technology is receiving increasing attention. Therefore, a SPR-based temperature se...
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Article
Open AccessThe ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis
Dysfunction of the ubiquitin-proteasome system (UPS) is involved in the pathogenesis of various malignancies including colorectal cancer (CRC). Ubiquitin domain containing 1 (UBTD1), a ubiquitin-like protein, ...
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Article
Progress and perspectives of metabolic biomarkers in human aortic dissection
Aortic dissection (AD) significantly threated human cardiovascular health, extensive clinical-scientific research programs have been executed to uncover the pathogenesis and prevention. Unfortunately, no speci...
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Article
Open AccessBiological impact and therapeutic implication of tumor-associated macrophages in hepatocellular carcinoma
The tumor microenvironment is a complex space comprised of normal, cancer and immune cells. The macrophages are considered as the most abundant immune cells in tumor microenvironment and their function in tumo...
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Article
Norwogonin aids in fighting MRSA-induced pneumonia by targeting agrAC to inhibit α-hemolysin production
The increasing prevalence of infections related to methicillin-resistant Staphylococcus aureus (MRSA) necessitates the exploration of innovative therapeutic strategies that diverge from conventional antibiotic tr...
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Article
Pathogenesis of cardiovascular diseases: effects of mitochondrial CF6 on endothelial cell function
Cardiovascular disease (CVD) stands as a predominant global cause of morbidity and mortality, necessitating effective and cost-efficient therapies for cardiovascular risk reduction. Mitochondrial coupling fact...
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Article
Correction: lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus
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Article
Retraction Note: Changes in Blood Pressure is Associated with Bone Loss in US Adults: A Cross-Sectional Study from NHANES 2005–2018
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Article
The role of hydrogen sulfide regulation of ferroptosis in different diseases
Ferroptosis is a programmed cell death that relies on iron and lipid peroxidation. It differs from other forms of programmed cell death such as necrosis, apoptosis and autophagy. More and more evidence indicat...
