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Life Sciences
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Article
Preparation of (S)-epichlorohydrin using a novel halohydrin dehalogenase by selective conformation adjustment
Chiral epichlorohydrin (ECH) is an attractive intermediate for chiral pharmaceuticals and chemicals preparation. The asymmetric synthesis of chiral ECH using 1,3-dicholoro-2-propanol (1,3-DCP) catalyzed by a h...
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An accurate monitoring method of peanut southern blight using unmanned aerial vehicle remote sensing
Peanut is a significant oilseed crop that is often affected by peanut southern blight, a disease that greatly reduces crop yield and quality. Therefore, accurate and timely monitoring of this disease is crucia...
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Comparison of Drought Stress Responses in Large- and Small-Rooted Rice Lines: Physiological, Anatomical, and Hormonal Changes
Drought stress severely restricts crop yields. Changes in root morphology and function are critical to rice performance under drought conditions, affecting water uptake efficiency, hormone regulation, and nutr...
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Quantifying corn LAI using machine learning and UAV multispectral imaging
Predicting leaf area index (LAI) is essential for understanding crop growth status and water-fertilizer management. The aim of this study was to evaluate the effectiveness of unmanned aerial vehicle (UAV) mult...
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Spatial and temporal patterns of cotton profitability in management zones based on soil properties and topography
Understanding spatial and temporal variability of absolute and relative profit within fields provides a basis for site-specific management of limited agricultural inputs such as water. The objectives of this s...
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Open AccessIntegrated transcriptomics and metabolomics provide insights into the biosynthesis of militarine in the cell suspension culture system of Bletilla striata
Militarine is a monomer molecule with abundant and distinctive biological properties, also the lead member of secondary metabolites in Bletilla striata, while its biosynthesis mechanism is still unknown. To impro...
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Open AccessNitrogen-fixing bacteria promote growth and bioactive components accumulation of Astragalus mongholicus by regulating plant metabolism and rhizosphere microbiota
The excessive application of chemical fertilizers in the cultivation of Astragalus mongholicus Bunge results in a reduction in the quality of the medicinal plant and compromises the sustainable productivity of th...
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Open AccessDraft genome assemblies of the ponerine ant Odontoponera transversa and the carpenter ant Camponotus friedae (Hymenoptera: Formicidae)
Ants are ecologically dominant insects in most terrestrial ecosystems, with more than 14,000 extant species in about 340 genera recorded to date. However, genomic resources are still scarce for most species, e...
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Open AccessExploring the challenges of RNAi-based strategies for crop protection
RNA silencing (or RNA interference, RNAi) initiated by double-stranded RNAs is a conserved mechanism for regulating gene expression in eukaryotes. RNAi-based crop protection strategies, including host-induced ...
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Regulation of oxidative stress response and antioxidant modification in Corynebacterium glutamicum
As an efficient and safe industrial bacterium, Corynebacterium glutamicum has extensive application in amino acid production. However, it often faces oxidative stress induced by reactive oxygen species (ROS), lea...
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Open AccessPhenotypic characterization and gene map** of hybrid necrosis in Triticum durum–Haynaldia villosa amphiploids
Phenotypical, physiological and genetic characterization was carried out on the hybrid necrosis gene from Haynaldia villosa, and the related gene Ne-V was mapped to chromosome arm 2VL.
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Open AccessTruncated tau interferes with the autophagy and endolysosomal pathway and results in lipid accumulation
The autophagy-lysosomal pathway plays a critical role in the clearance of tau protein aggregates that deposit in the brain in tauopathies, and defects in this system are associated with disease pathogenesis. H...
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Seamless site-directed mutagenesis in complex cloned DNA sequences using the RedEx method
Seamless site-directed mutagenesis is an important technique for studying protein functions, tuning enzyme catalytic activities and modifying genetic elements in multiple rounds because it can insert, delete o...
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Open AccessHMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage
Drug-induced organic damage encompasses various intricate mechanisms, wherein HMGB1, a non-histone chromosome-binding protein, assumes a significant role as a pivotal hub gene. The regulatory functions of HMGB...
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Open Accessm1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA
N1-Methyladenosine (m1A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics and biological functions of mRNA m1A modification in adult hi...
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Up-regulation of miR-126 via DNA methylation in hypoxia-preconditioned endothelial cells may contribute to hypoxic tolerance of neuronal cells
Endothelial cells (ECs) can confer neuroprotection by secreting molecules. This study aimed to investigate whether DNA methylation contributes to the neuroprotective gene expression induced by hypoxia precondi...
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Open AccessDietary silymarin improves performance by altering hepatic lipid metabolism and cecal microbiota function and its metabolites in late laying hens
Liver lipid dysregulation is one of the major factors in the decline of production performance in late-stage laying hens. Silymarin (SIL), a natural flavonolignan extracted from milk thistle, is known for its ...
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Open AccessThe ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis
Dysfunction of the ubiquitin-proteasome system (UPS) is involved in the pathogenesis of various malignancies including colorectal cancer (CRC). Ubiquitin domain containing 1 (UBTD1), a ubiquitin-like protein, ...
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Progress and perspectives of metabolic biomarkers in human aortic dissection
Aortic dissection (AD) significantly threated human cardiovascular health, extensive clinical-scientific research programs have been executed to uncover the pathogenesis and prevention. Unfortunately, no speci...
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Open AccessStructural basis of tethered agonism and G protein coupling of protease-activated receptors
Protease-activated receptors (PARs) are a unique group within the G protein-coupled receptor superfamily, orchestrating cellular responses to extracellular proteases via enzymatic cleavage, which triggers intr...
