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Open AccessThe oyster genome reveals stress adaptation and complexity of shell formation
The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads ...
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Open AccessGenome of the Chinese tree shrew
Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as model...
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Open Access2-D shape completion with shape priors
We propose new techniques for 2-D shape/contour completion, which is one of the important research topics related to shape analysis and computer vision, e.g. the detection of incomplete objects due to occlusio...
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Open AccessThe locust genome provides insight into swarm formation and long-distance flight
Locusts are one of the world’s most destructive agricultural pests and represent a useful model system in entomology. Here we present a draft 6.5 Gb genome sequence of Locusta migratoria, which is the largest ani...
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Open AccessSpider genomes provide insight into composition and evolution of venom and silk
Spiders are ecologically important predators with complex venom and extraordinarily tough silk that enables capture of large prey. Here we present the assembled genome of the social velvet spider and a draft a...
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Correction: Corrigendum: Spider genomes provide insight into composition and evolution of venom and silk
Nature Communications 5: Article number: 3765 (2014); Published: 6 May 2014; Updated: 6 August 2014. The original version of the Supplementary Information attached to this Article contained an error in the num...
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Open AccessMudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes
Mudskippers are amphibious fishes that have developed morphological and physiological adaptations to match their unique lifestyles. Here we perform whole-genome sequencing of four representative mudskippers to...
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Open AccessZnO Nanorod Array Grown on Ag Layer: A Highly Efficient Fluorescence Enhancement Platform
ZnO nanorods (NRs) are known for ultra-sensitive biomolecule detection through fluorescence enhancement. In this work, we demonstrate that ZnO NR arrays grown on Ag layers can significantly improve the enhance...
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Correction: Corrigendum: Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax
Nature Communications 5: Article number: 3966 (2014); Published online: 3 June 2014; Updated: 12 Aug 2015. In Fig. 2 of this Article, the CLOCK protein sequence of the blind mole rat (Spalax) was inadvertently...
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Open AccessOutbred genome sequencing and CRISPR/Cas9 gene editing in butterflies
Butterflies are exceptionally diverse but their potential as an experimental system has been limited by the difficulty of deciphering heterozygous genomes and a lack of genetic manipulation technology. Here we...
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Open AccessCharacterization of DNA variants in the human kinome in breast cancer
Kinases play a key role in cancer biology and serve as potential clinically useful targets for designing cancer therapies. We examined nucleic acid variations in the human kinome and several known cancer-relat...
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Open AccessScreening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis
Rapid and efficient methods for the determination of cured tuberculosis (TB) are lacking. A total of 85 differentially expressed serum proteins were identified by iTRAQ labeling coupled with two-dimensional li...
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Open AccessPrognostic nomogram integrated systemic inflammation score for patients with esophageal squamouscell carcinoma undergoing radical esophagectomy
Growing evidence indicates that nomogram combined with the biomarkers of systemic inflammation response could provide more accurate prediction than conventional staging systems in tumors. This study aimed to e...
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Open AccessSpectroscopic Study of Terahertz Generation in Mid-Infrared Quantum Cascade Lasers
Terahertz quantum cascade laser sources based on intra-cavity difference-frequency generation are currently the only room-temperature mass-producible diode-laser-like emitters of coherent 1–6 THz radiation. De...
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Open AccessA Molecular Chipper technology for CRISPR sgRNA library generation and functional map** of noncoding regions
Clustered regularly-interspaced palindromic repeats (CRISPR)-based genetic screens using single-guide-RNA (sgRNA) libraries have proven powerful to identify genetic regulators. Applying CRISPR screens to inter...
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Open AccessAutophagy inhibition of hsa-miR-19a-3p/19b-3p by targeting TGF-β R II during TGF-β1-induced fibrogenesis in human cardiac fibroblasts
Transforming growth factor-β1 (TGF-β1) plays an important role on fibrogenesis in heart disease. MicroRNAs have exhibited as crucial regulators of cardiac homeostasis and remodeling in various heart diseases. MiR...
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Open AccessThe Atlantic salmon genome provides insights into rediploidization
The whole-genome duplication 80 million years ago of the common ancestor of salmonids (salmonid-specific fourth vertebrate whole-genome duplication, Ss4R) provides unique opportunities to learn about the evolu...
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Open AccessThe acquisition of Clostridium tyrobutyricum mutants with improved bioproduction under acidic conditions after two rounds of heavy-ion beam irradiation
End-product inhibition is a key factor limiting the production of organic acid during fermentation. Two rounds of heavy-ion beam irradiation may be an inexpensive, indispensable and reliable approach to increa...
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Open AccessThermopile detector of light ellipticity
Polarimetric imaging is widely used in applications from material analysis to biomedical diagnostics, vision and astronomy. The degree of circular polarization, or light ellipticity, is associated with the S3 Sto...
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Open AccessSystemic Immune-Inflammation Index Predicts Prognosis of Patients with Esophageal Squamous Cell Carcinoma: A Propensity Score-matched Analysis
Systemic immune-inflammation index (SII), based on peripheral lymphocyte, neutrophil, and platelet counts, was recently investigated as a prognostic marker in several tumors. However, SII has not been reported...