42 Result(s)
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Open AccessPharmacokinetic Modeling of the Effect of Tariquidar on Ondansetron Disposition into the Central Nervous System
Serotonin (5-HT3) receptor antagonists are promising agents for treatment of neuropathic pain. However, insufficient drug exposure at the central nervous system (CNS) might result in lack of efficacy. The goal of...
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Open AccessAerosolization Performance of Immunoglobulin G by Jet and Mesh Nebulizers
Recently, many preclinical and clinical studies have been conducted on the delivery of therapeutic antibodies to the lungs using nebulizers, but standard treatment guidelines have not yet been established. Our...
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Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides
Biological cell membranes are a natural barrier for living cells. In the last few decades, the cell membrane has been the main hurdle in the efficient delivery of bioactive and therapeutic agents. To increase ...
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The effects of BRL-50481 on ovalbumin-induced asthmatic lung inflammation exacerbated by co-exposure to Asian sand dust in the murine model
Asian sand dust (ASD), which mainly originates in China and Mongolia in the spring and blows into Korea, can exacerbate respiratory and immunological diseases. This study aims to observe effects of co-exposure...
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Open AccessCorrection to: Site-selective and metal-free C–H nitration of biologically relevant N-heterocycles
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Open AccessSite-selective and metal-free C–H nitration of biologically relevant N-heterocycles
The site-selective and metal-free C–H nitration reaction of quinoxalinones and pyrazinones as biologically important N-heterocycles with t-butyl nitrite is described. A wide range of quinoxalinones were efficient...
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Engineering Quick- and Long-acting Naloxone Delivery Systems for Treating Opioid Overdose
Opioids have been the main factor for drug overdose deaths in the United States. Current naloxone delivery systems are effective in mitigating the opioid effects only for hours. Naloxone-loaded poly(lactide-co...
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Open AccessTriamterene induces autophagic degradation of lysosome by exacerbating lysosomal integrity
The maintenance of lysosomal integrity is essential for lysosome function and cell fate. Damaged lysosomes are degraded by lysosomal autophagy, lysophagy. The mechanism underlying lysophagy remains largely unk...
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Open AccessRegulatory roles of G-protein coupled receptors in adipose tissue metabolism and their therapeutic potential
The high incidence of obesity has increased the need to discover new therapeutic targets to combat obesity and obesity-related metabolic diseases. Obesity is defined as an abnormal accumulation of adipose tiss...
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Ubiquitin–proteasome system (UPS) as a target for anticancer treatment
The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for protein quality control and homeostasis. Dysregulation of the UPS has been implicated in numerous diseases, including...
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Correction to: Transcriptional suppression of androgen receptor by 18β-glycyrrhetinic acid in LNCaP human prostate cancer cells
The authors regret to inform that authors Pramod Aryal and Shuang Wu were inadvertently omitted from authorship of the manuscript above at the time of original submission. Pramod Aryal and Shuang Wu were contr...
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Open AccessPalmitoylation-mediated synaptic regulation of AMPA receptor trafficking and function
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is a major glutamate-gated ion channel in the brain and is important for synaptic transmission, synaptic plasticity, and learning. Palm...
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Correction to: Development of a column-switching LC-MS/MS method of tramadol and its metabolites in hair and application to a pharmacogenetic study
In the original version of the article titled “Development of a column-switching LC-MS/MS method of tramadol and its metabolites in hair and application to a pharmacogenetic study”, published in 41(5):554–563 ...
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Open AccessInhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3
Ultraviolet B (UVB) irradiation causes sunburn, inflammatory responses, dysregulation of immune function, oxidative stress, DNA damage and photocarcinogenesis on skin. Rosemary (Rosmarinus officinalis L.) has bee...
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Retraction Note to: Analysis of loxoprofen in tablets, patches, and equine urine as tert-butyldimethylsilyl derivative by gas chromatography-mass spectrometry
The authors have retracted this article [1] because after publication they became aware that the equine urine samples analysed for loxoprofen in this study were in fact equine plasma samples. Therefore the res...
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Open AccessTargeting epigenetics for cancer therapy
Cancer can be identified as a chaotic cell state, which breaks the rules that govern growth and reproduction, with main characteristics such as uncontrolled division, invading other tissues, usur** resources...
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Correction to: Causal effects of synthetic chemicals on mitochondrial deficits and diabetes pandemic
We regret that there is an error in the labeling of Fig. 4 of the published original article. The concentration of MPP+ should be corrected to 1.0 mM instead of 0.5 mM. The corrected figure should be.
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Correction to: Resveratrol attenuates norepinephrine-induced ovarian cancer invasiveness through downregulating hTERT expression
Unfortunately, there are some errors in Fig. 1b and Fig. 3a of the article.
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Article
Correction to: Effects of Moisture-Induced Crystallization on the Aerosol Performance of Spray Dried Amorphous Ciprofloxacin Powder Formulations
Page 4, right column, under section heading “In-Vitro Aerosol Performance”, line 11.
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Open AccessProteomic and transcriptomic analysis of lung tissue in OVA-challenged mice
Asthma is a long term inflammatory disease of the airway of lungs characterized by variable airflow obstruction and bronchospasm. Asthma is caused by a complex combination of environmental and genetic interact...
