2,924 Result(s)
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Open AccessDevelopment of a novel testis-on-a-chip that demonstrates reciprocal crosstalk between Sertoli and Leydig cells in testicular tissue
The reciprocal crosstalk between testicular Sertoli and Leydig cells plays a vital role in supporting germ cell development and maintaining testicular characteristics and spermatogenesis. Conventional 2D and t...
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Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague–Dawley rats and Beagle dogs
The emergence of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic, prompting rapid vaccine development. Although vaccines are effective, t...
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Persistence and enrichment of dominant T cell clonotypes in expanded tumor-infiltrating lymphocytes of breast cancer
Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown promising results in cancer treatment, including breast cancer. However, clonal dynamics and clinical significance of TIL expansion e...
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3D Bioprinting Strategies for Articular Cartilage Tissue Engineering
Articular cartilage is the avascular and aneural tissue which is the primary connective tissue covering the surface of articulating bone. Traumatic damage or degenerative diseases can cause articular cartilage...
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Open AccessMAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis
The asymmetric division of stem cells permits the maintenance of the cell population and differentiation for harmonious progress. Develo** mouse incisors allows inspection of the role of the stem cell niche ...
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Open AccessFGFR3 drives Aβ-induced tau uptake
The amyloid cascade hypothesis suggests that amyloid beta (Aβ) contributes to initiating subsequent tau pathology in Alzheimer’s disease (AD). However, the underlying mechanisms through which Aβ contributes to...
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Cell membrane camouflaged nanoparticle strategy and its application in brain disease: a review
Drug delivery to the brain is difficult, owing of the presence of a unique structure called the blood–brain barrier (BBB). Thus, strategies that facilitate drug delivery to the brain lesion sites via BBB penet...
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Open AccessPHGDH: a novel therapeutic target in cancer
Serine is a key contributor to the generation of one-carbon units for DNA synthesis during cellular proliferation. In addition, it plays a crucial role in the production of antioxidants that prevent abnormal p...
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Intranasal delivery of siRNA targeting NR2B attenuates cancer-associated neuropathic pain
This study aimed to reduce cancer-associated pain by blocking pain signals through the intranasal administration of siRNA targeting the NMDA subunit NR2B (siNR2B).
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HIF-1α and MIF enhance neutrophil-driven type 3 immunity and chondrogenesis in a murine spondyloarthritis model
The hallmarks of spondyloarthritis (SpA) are type 3 immunity-driven inflammation and new bone formation (NBF). Macrophage migration inhibitory factor (MIF) was found to be a key driver of the pathogenesis of S...
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New insights into the ontogeny, diversity, maturation and survival of long-lived plasma cells
Plasma cells are unique immune effectors, capable of producing large amounts of high-affinity antibodies that protect against pathogenic infections. Although most plasma cells have short lifespans, certain con...
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Cancer fatalism, social media informational awareness, and education
Understand if cancer fatalism among adult social media users in the United States is linked to social media informational awareness and if the relationship varies by education level.
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Open AccessCorrection: Systematic review of fatigue severity in ME/CFS patients: insights from randomized controlled trials
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Open AccessAuthor Correction: Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformers
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Open AccessCorrection: H3.3-G34W in giant cell tumor of bone functionally aligns with the exon choice repressor hnRNPA1L2
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Highly efficient and specific regulation of gene expression using enhanced CRISPR-Cas12f system
The recently developed CRISPR activator (CRISPRa) system uses a CRISPR-Cas effector-based transcriptional activator to effectively control the expression of target genes without causing DNA damage. However, ex...
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Open AccessAuthor Correction: Inhibition of lysine acetyltransferase KAT6 in ER+HER2− metastatic breast cancer: a phase 1 trial
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Synthesis, Invitro Cytotoxic Activity and Optical Analysis of Substituted Schiff Base Derivatives
Fluorescent cytotoxic compounds with readout delivery are crucial in chemotherapy. The growing demands of these treatment strategies require the novel heterocyclic molecules with better selectivity alongside f...
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Advancements of hot-melt extrusion technology to address unmet patient needs and pharmaceutical quality aspects
Hot-melt extrusion (HME) significantly affects pharmaceutical manufacturing by enhancing drug solubility and bioavailability. Advancements in HME technology to produce FDA-approved drugs have highlighted its r...
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Author Correction: A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
