277 Result(s)
within
Biomedicine
Biomedicine, general
Cancer Research
Epidemiology
**su Park
-
Article
The Malignancy of Cancer at Different Ages: A Histological Study
-
Article
The epidemiology of AIDS-associated non-Hodgkin's lymphoma in the World Health Organization European Region
This paper describes the epidemiology of AIDS-associated non-Hodgkin's lymphoma (NHL) in the World Health Organization (WHO) European Region. Data, collected by the WHO Collaborating Centre on AIDS in Paris, F...
-
Article
Interleukin 2 therapy in cancer: identification of responders
C-reactive protein (CRP) levels in serum were measured in fifteen patients with metastatic colorectal carcinoma, prior to and during treatment with a continuous intravenous infusion of rIL.2. Patients were sub...
-
Article
Characterization of dihydropyrimidine dehydrogenase in human colorectal tumours
Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme for degradation of 5-fluorouracil (5-FU). DPD activity is highly variable in liver and peripheral mononuclear cells (PMNCs) and it has not been...
-
Article
Regulation of interferon responses in medulloblastoma cells by interferon regulatory factor-1 and -2
Transcriptional activator interferon regulatory factor (IRF)-1 and repressor IRF-2 are known to play a critical role in the regulation of interferon (IFN) responses and oncogenesis in fibroblasts. Although the...
-
Article
Open AccessSynergistic inhibition of prostate cancer cell lines by a 19- nor hexafluoride vitamin D3 analogue and anti-activator protein 1 retinoid
The secosteroid hormones, all- trans- and 9- cis -retinoic acid and vitamin D3, have demonstrated significant capacity to control proliferation in itro of many solid tumour cell lines. Cooperative synergistic eff...
-
Article
Open AccessPrognostic value of DNA flow cytometry in stomach cancer: a 5-year prospective study
The role of DNA flow cytometry in the prediction of prognosis for patients with stomach cancer remains to be defined. Thus we studied prospectively the role of DNA flow cytometry as a prognosis indicator in st...
-
Article
Open AccessReproductive factors related to the risk of colorectal cancer by subsite: a case-control analysis
The authors hypothesized that reproductive factors of colorectal cancer, which are probably mediated by endogenous hormones, would differ according to colonic subsite. Information on reproductive factors was o...
-
Article
Open AccessDeletion map** of chromosome 16q in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) frequently shows an allelic imbalance (AI) on chromosome 16q. In order to define the commonly affected regions on chromosome 16q, we assessed AI studies in 41 HCCs using a panel ...
-
Article
Open AccessAcidic environment causes apoptosis by increasing caspase activity
An exposure of HL-60 human promyelocytic leukaemia cells to acidic media with pH 6.2–6.6 caused an up-regulation of Bax protein expression within 2 h, which lasted for longer than 6 h. On the other hand, the a...
-
Article
Open AccessCyclin D1 overexpression is an indicator of poor prognosis in resectable non-small cell lung cancer
Cyclin D1 is one of the G1 cyclins that control cell cycle progression by allowing G1 to S transition. Overexpression of cyclin D1 has been postulated to play an important role in the development of human canc...
-
Article
Open AccessDifferential regulation of MAP kinase cascade in human colorectal tumorigenesis
Hyper-activation of mitogen-activated protein kinase (MAPK) has recently been reported in several human cancers and activation of MAPK in those cancers may be associated with carcinogenesis through aberrant ce...
-
Article
Open AccessGermline mutations of the STK11 gene in Korean Peutz–Jeghers syndrome patients
Peutz–Jeghers syndrome (PJS) is an autosomal dominantly inherited disease characterized by hamartomatous gastrointestinal polyps and mucocutaneous pigmentation, with an increased risk for various neoplasms, in...
-
Article
Open AccessExpression of hMLH1 is inactivated in the gastric adenomas with enhanced microsatellite instability
Microsatellite instability (MSI) and frameshift mutations in the genes containing coding nucleotide repeats have been reported in a subset of gastric adenomas, however the inactivation profiles of DNA mismatch...
-
Article
Open AccessEstablishment and characterisation of six human biliary tract cancer cell lines
Human cell lines established from biliary tract cancers are rare, and only five have been reported previously. We report the characterisation of six new six biliary tract cancer cell lines (designated SNU-245,...
-
Article
Open AccessGenetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women
A case–control study was performed to assess the potential influence of CYP19 Arg264Cys and CYP1B1 Leu432Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The resu...
-
Article
Open AccessArginine deiminase: a potential inhibitor of angiogenesis and tumour growth
Hydrolysis of plasma arginine to citrulline by arginine deiminase (ADI) was recently shown to suppress lipopolysaccharide-induced nitric oxide (NO) synthesis. Since arginine is the precursor of NO, and the lat...
-
Article
Open AccessHypermethylation of the hTERT promoter inhibits the expression of telomerase activity in normal oral fibroblasts and senescent normal oral keratinocytes
Telomerase activity in human cells closely correlates with the expression of its catalytic subunit, telomerase reverse transcriptase (hTERT). Previously, we reported the lack of telomerase activity in normal huma...
-
Article
Open AccessDifferential SPARC mRNA expression in Barrett's oesophagus
Barrett's oesophagus (BE) is the precursor lesion to adenocarcinoma of the oesophagus. Understanding of the molecular alterations in this multistage process may contribute to improved diagnosis and treatment. ...
-
Article
Open AccessBRAF mutations in non-Hodgkin's lymphoma
Ras proteins control signalling pathways that are key regulators of several aspects of normal cell growth and malignant transformation. BRAF, which encodes an RAF family member in the downstream pathway of RAS, i...
