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Article
Open AccessData driven multiple objective optimization of AAO process towards wastewater effluent biological toxicity reduction
While the anaerobic-anoxic-oxic (AAO) process is the most widely applied biological wastewater treatment process in municipal wastewater treatment plants (WWTPs), it struggles to meet the increasing demands on...
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Article
Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease
APOE4 is the strongest genetic risk factor for Alzheimer’s disease (AD), with increased odds ratios in female carriers. Targeting amyloid plaques shows modest improvement in male non-APOE4 carriers. Leveraging...
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Article
Open AccessPlants interfere with non-self recognition of a phytopathogenic fungus via proline accumulation to facilitate mycovirus transmission
Non-self recognition is a fundamental aspect of life, serving as a crucial mechanism for mitigating proliferation of molecular parasites within fungal populations. However, studies investigating the potential ...
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Article
Open AccessBacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer’s disease mouse models
The gut microbiota and microglia play critical roles in Alzheimer’s disease (AD), and elevated Bacteroides is correlated with cerebrospinal fluid amyloid-β (Aβ) and tau levels in AD. We hypothesize that Bacteroid...
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Article
Open AccessPhysiological versatility of ANME-1 and Bathyarchaeotoa-8 archaea evidenced by inverse stable isotope labeling
The trophic strategy is one key principle to categorize microbial lifestyles, by broadly classifying microorganisms based on the combination of their preferred carbon sources, electron sources, and electron si...
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Article
Necroptosis blockade prevents lung injury in severe influenza
Severe influenza A virus (IAV) infections can result in hyper-inflammation, lung injury and acute respiratory distress syndrome1–5 (ARDS), for which there are no effective pharmacological therapies. Necroptosis i...
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Article
Synthesis of Highly-Active Cu2O for Degradation of MO Dyes under Light and Non-light Conditions by Electrochemical Method
The growth of Cu2O crystal planes was be controlled by adding surfactant to the NaCl solution in this manuscript. The structure and composition of the synthesized Cu2O particles were characterized by X‑ray diffra...
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Article
Numerical investigation on interaction between regular waves and a fully submerged horizontal cylinder
This paper presents a 2-D numerical investigation on interaction between regular waves and a fully submerged horizontal cylinder. A mathematical model of numerical wave tank with two-way fluid-solid interactio...
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Article
Open AccessHow well did the consensus methods apply in the guideline development of traditional Chinese medicine: a web-based survey in China
Consensus methods are crucial in develo** clinical guidelines. Different methods, such as the Delphi and nominal group techniques, are commonly used, but there is a lack of detailed instructions on how to im...
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Article
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints
The APOE4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). The contribution of microglial APOE4 to AD pathogenesis is unknown, although APOE has the most enriched gene expressi...
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Article
Suppressing a phosphohydrolase of cytokinin nucleotide enhances grain yield in rice
One-step and two-step pathways are proposed to synthesize cytokinin in plants. The one-step pathway is mediated by LONELY GUY (LOG) proteins. However, the enzyme for the two-step pathway remains to be identifi...
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Article
Long Non-Coding RNA-GDA-1 Promotes Keratinocyte Proliferation and Psoriasis Inflammation by Regulating the STAT3/NF-κB Signaling Pathway via Forkhead Box M1
Psoriasis is a chronic inflammatory skin disease associated with multiple comorbidities and complex pathogenesis. Long non-coding RNAs (lncRNAs) play an important regulatory role in many diseases, including ps...
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Open AccessVγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. The innate and adaptive immune responses play an important role in the pathogenesis of TBI. Gamma-delta (γδ) T cells have been shown ...
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Article
Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease
Microglia play a critical role in brain homeostasis and disease progression. In neurodegenerative conditions, microglia acquire the neurodegenerative phenotype (MGnD), whose function is poorly understood. Micr...
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Article
Bio-straw or not? Determinants of consumption intention under the plastic straw ban
A new plastic ban has banned the use of single-use non-degradable plastic drinking straws in China’s food and beverage industry by the end of 2020. However, this has caused widespread discussion and complaints...
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Article
Controlling contaminants using a far-UVC-based advanced oxidation process for potable reuse
Increasing the efficiency of the processing units used to purify municipal wastewater to potable quality would enhance the sustainability of potable reuse. Conventional advanced oxidation processes using 254 n...
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Article
Role of high-precision real-time digital image based on data simulation in the construction of rural public space environment
Building a livable rural environment is the main process to achieve rural revitalization. An ideal rural environment contains many factors, such as health, safety, convenience and comfort. On the basis of liva...
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Article
Open AccessNovel biological aqua crust enhances in situ metal(loid) bioremediation driven by phototrophic/diazotrophic biofilm
Understanding the ecological and environmental functions of phototrophic biofilms in the biological crust is crucial for improving metal(loid) (e.g. Cd, As) bioremediation in mining ecosystems. In this study, in ...
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Article
ZBP1 inflames the SARS-CoV-2-infected lung
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Open AccessThe majority of microorganisms in gas hydrate-bearing subseafloor sediments ferment macromolecules
Gas hydrate-bearing subseafloor sediments harbor a large number of microorganisms. Within these sediments, organic matter and upward-migrating methane are important carbon and energy sources fueling a light-in...
