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Article
Open AccessMultiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization
Although adamantinomatous craniopharyngioma (ACP) is a tumour with low histological malignancy, there are very few therapeutic options other than surgery. ACP has high histological complexity, and the unique f...
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Article
Open AccessSingle VHH-directed BCMA CAR-NK cells for multiple myeloma
Natural killer (NK) cells are promising alternatives for the production of “off-the-shelf” CAR products, posing a lower risk of cytokine release syndrome (CRS) than CAR-T cells. We synthesized four single VHH-...
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Article
Open AccessA Selective-Response Hypersensitive Bio-Inspired Strain Sensor Enabled by Hysteresis Effect and Parallel Through-Slits Structures
A bio-inspired flexible strain sensor with hypersensitivity and highly selective frequency response is prepared by styrene–isoprene–styrene combined with monolayer graphene.
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Open AccessGolden section criterion to achieve droplet trampoline effect on metal-based superhydrophobic surface
Clarifying the consecutive droplet rebound mechanisms can provide scientific inspirations to regulate dynamic wettability of superhydrophobic surface, which facilitates the practical applications on efficient ...
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Article
Open AccessIntrinsic Kinematics of the Tibiotalar and Subtalar Joints during Human Walking based on Dynamic Biplanar Fluoroscopy
Accurate knowledge of the kinematics of the in vivo Ankle Joint Complex (AJC) is critical for understanding the biomechanical function of the foot and assessing postoperative rehabilitation of ankle disorders,...
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Article
Open AccessObservation of nonlinear disclination states
Introduction of controllable deformations into periodic materials that lead to disclinations in their structure opens novel routes for construction of higher-order topological insulators hosting topological st...
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Article
Open AccessBispecific antibodies targeting BCMA, GPRC5D, and FcRH5 for multiple myeloma therapy: latest updates from ASCO 2023 Annual Meeting
Several bispecific antibodies (bsAbs) targeting BCMA, GPRC5D, and FcRH5 are in clinical trials for heavily pretreated multiple myeloma (MM) patients. Teclistamab was approved for relapsed/refractory MM therapy...
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Article
Open AccessFiber-dominated Soft Actuators Inspired by Plant Cell Walls and Skeletal Muscles
Morphing botanical tissues and animal muscles are all fiber-mediated composites, in which fibers play a passive and active role, respectively. Herein, inspired by the mechanism of fibers functioning in morphin...
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Article
Open AccessDesign of a Flexible Bionic Ankle Prosthesis Based on Subject-specific Modeling of the Human Musculoskeletal System
A variety of prosthetic ankles have been successfully developed to reproduce the locomotor ability for lower limb amputees in daily lives. However, they have not been shown to sufficiently improve the natural ...
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Article
Open AccessBionic Step** Motors Driven by Piezoelectric Materials
By imitating the behavioral characteristics of some typical animals, researchers develop bionic step** motors to extend the working range of piezoelectric materials and utilize their high accuracy advantage ...
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Article
Open AccessBioinspired Multi-Metal Structures Produced via Direct Ink Writing
Bioinspired Multi-Metal Structures (MMSs) combine distinct properties of multiple materials, benefiting from improved properties and providing superior designs. Additive Manufacturing (AM) exhibits enormous ad...
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Article
Open AccessBioinspired Strategies for Excellent Mechanical Properties of Composites
Develo** high-performance composite materials is of great significance as a strong support for high-end manufacturing. However, the design and optimization of composite materials lack a theoretical basis and...
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Article
Open AccessLoad-dependent Variable Gearing Mechanism of Muscle-like Soft Actuator
Pennate muscle is characterized by muscle fibers that are oriented at a certain angle (pennation angle) relative to the muscle’s line of action and rotation during contraction. This fiber rotation amplifies th...
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Article
Open AccessAggravated stress fluctuation and mechanical size effects of nanoscale lamellar bone pillars
The size effects of mechanical properties influence the microdeformation behaviors and failure mechanisms of hierarchical lamellar bones. Investigations of the continuous deformation behaviors and structure–be...
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Article
Open AccessSmart Bionic Surfaces with Switchable Wettability and Applications
In order to satisfy the needs of different applications and more complex intelligent devices, smart control of surface wettability will be necessary and desirable, which gradually become a hot spot and focus i...
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Article
Open AccessCharacteristics of prescriptions and costs for acute upper respiratory tract infections in Chinese outpatient pediatric patients: a nationwide cross-sectional study
To understand the characteristics of prescriptions and costs in pediatric patients with acute upper respiratory infections (AURI) is important for the regulation of outpatient care and reimbursement policy. Th...
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Article
Open AccessCrack-based and Hair-like Sensors Inspired from Arthropods: A Review
Over a long period of time, arthropods evolve to have two excellent mechanical sensilla of slit sensilla and trichobothria sensilla, which construct a perfect perception system. The former mainly perceives the...
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Article
Open AccessProgress in Bio-inspired Anti-solid Particle Erosion Materials: Learning from Nature but Going beyond Nature
Solid particle erosion is a common phenomenon in engineering fields, such as manufacturing, energy, military and aviation. However, with the rising industrial requirements, the development of anti-solid partic...
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Article
Open AccessRapid Fabrication of Bio-inspired Antireflection Film Replicating From Cicada Wings
Inspired by cicada wings, a flexible film with self-cleaning and broadband antireflection properties was fabricated with a rapid, straightforward and cost-effective method. The cicada wing was selected as the ...
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Article
Open AccessClustering K-SVD for sparse representation of images
K-singular value decomposition (K-SVD) is a frequently used dictionary learning (DL) algorithm that iteratively works between sparse coding and dictionary updating. The sparse coding process generates sparse c...
