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Article
Open AccessDevelopment of machine learning models for patients in the high intrahepatic cholangiocarcinoma incidence age group
Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis and is understudied. Based on the clinical features of patients with ICC, we constructed machine learning models to understand their importance on sur...
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Article
Evolutionary mechanism and frequency response of graphite electrode at extreme temperatures
The battery management system is employed to monitor the external temperature of the lithium-ion battery in order to detect any potential overheating. However, this outside–in detection method often suffers fr...
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Article
Cu nanowire array with designed interphases enabling high performance Si anode toward flexible lithium-ion battery
To meet the growing demand for wearable smart electronic devices, the development of flexible lithium-ion batteries (LIBs) is essential. Silicon is an ideal candidate for the anode material of flexible lithium...
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Article
Open AccessAcid-triggered radical polymerization of vinyl monomers
Reversible addition–fragmentation chain-transfer (RAFT) polymerization is one of the most versatile and robust controlled radical polymerization methods owing to its broad material scope and high tolerance to ...
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Article
Molecular Dynamics Simulation Studies on the Micromorphology and Proton Transport of Nafion/Ti3C2Tx Composite Membrane
The perfluorosulfonic acid (PFSA) membrane doped with two-dimensional conductive filler Ti3C2Tx is a fuel cell proton exchange membrane with high application potential. Experimental studies showed that the proton...
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Article
Open AccessTissue factor overexpression promotes resistance to KRAS-G12C inhibition in non-small cell lung cancer
The recently approved KRASG12C mutation-specific inhibitors sotorasib and adagrasib (KRASG12C-I) represent a promising therapy for KRASG12C-driven non-small cell lung cancer (NSCLC). However, many eligible patien...
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Article
Open AccessUSP43 impairs cisplatin sensitivity in epithelial ovarian cancer through HDAC2-dependent regulation of Wnt/β-catenin signaling pathway
Epithelial ovarian cancer (EOC) is the leading cause of cancer death all over the world. USP43 functions as a tumor promoter in various malignant cancers. Nevertheless, the biological roles and mechanisms of U...
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Article
Open AccessA macrophage related signature for predicting prognosis and drug sensitivity in ovarian cancer based on integrative machine learning
Ovarian cancer ranks the leading cause of gynecologic cancer-related death in the United States and the fifth most common cause of cancer-related mortality among American women. Increasing evidences have highl...
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Article
Fluorescence-amplified nanocrystals in the second near-infrared window for in vivo real-time dynamic multiplexed imaging
Optical imaging in the second near-infrared window (NIR-II, 1,000–1,700 nm) holds great promise for non-invasive in vivo detection. However, real-time dynamic multiplexed imaging remains challenging due to the...
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Article
Do green financial and non-financial policies achieve the carbon neutrality target?
Due to the pressing need to combat climate change, reaching carbon neutrality—defined as having net-zero greenhouse gas emissions—has elevated to the status of a worldwide priority. While non-financial policie...
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Article
Open AccessInvestigation and evaluation methods of shallow geothermal energy considering the influences of fracture water flow
The energy replenishment and heat convection induced by fracture water flowing through the rock mass impact the shallow geothermal energy occurrence, transfer and storage mechanisms in it. In this article, a s...
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Article
Open AccessSite-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma
Chemotherapy remains as the first-choice treatment option for triple-negative breast cancer (TNBC). However, the limited tumor penetration and low cellular internalization efficiency of current nanocarrier-bas...
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Article
Open AccessRole of N6-methyladenosine RNA modification in gastric cancer
N6-methyladenosine (m6A) RNA methylation is the most prevalent internal modification of mammalian messenger RNA. The m6A modification affects multiple aspects of RNA metabolism, including processing, splicing,...
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Article
AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage
The receptor tyrosine kinase AXL is an emerging driver of cancer recurrence, while its molecular mechanism remains unclear. In this study we investigated how AXL regulated the disease progression and poor prog...
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Article
Open AccessMiR-146a-5p delivered by hucMSC extracellular vesicles modulates the inflammatory response to sulfur mustard-induced acute lung injury
Sulfur mustard (SM) is a highly toxic chemical warfare agent that has caused numerous casualties during wars and conflicts in the past century. Specific antidotes or therapeutic strategies are rare due to the ...
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Chapter and Conference Paper
DC Grid-Connected Control Strategy of Doubly-Fed Induction Generators Based on Stator Side Uncontrolled Rectifier
DFIGs connected to DC grids are widely used in large-scale wind power transmission and DC microgrids. Among them, the grid-connected mode of uncontrolled rectification on the stator side has become an importan...
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Article
An improved indoor pedestrian dead reckoning algorithm using ambient light and sensors
Aiming at the problem of high cost and heavy preparation workload of indoor positioning technology, this paper proposes an ambient light-assisted smartphone-based pedestrian dead reckoning (PDR) indoor positio...
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Article
Therapeutic efficacy and mechanism of CD73-TGFβ dual-blockade in a mouse model of triple-negative breast cancer
Although chemotherapy and recently approved immunotherapies have improved treatment of triple-negative breast cancer (TNBC), the clinical outcome for this deadly disease remains unsatisfactory. We found that b...
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Article
Life Satisfaction in China, 2010–2018: Trends and Unique Determinants
This study is one of the first to explore the 5 waves of the China Family Panel Studies data from 2010 to 2018, assessing determinants of life satisfaction among a representative sample of Chinese individuals ...
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Article
Transcriptomic analysis reveals process of autolysis of Kluyveromyces marxianus in vacuum negative pressure and the higher temperature
Kluyveromyces marxianus is expected to be used in the production of yeast extracts due to its good fermentation ability and nutritional properties. Yeast autolysis is a key process to produce yeast extract and va...
