796 Result(s)
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Open AccessNilotinib treatment outcomes in autosomal dominant spinocerebellar ataxia over one year
We evaluated the efficacy and safety of 1-year treatment with nilotinib (Tasigna®) in patients with autosomal dominant spinocerebellar ataxia (ADSCA) and the factors associated with responsiveness. From an instit...
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Open AccessMultiparametric MRI–based radiomic models for early prediction of response to neoadjuvant systemic therapy in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is often treated with neoadjuvant systemic therapy (NAST). We investigated if radiomic models based on multiparametric Magnetic Resonance Imaging (MRI) obtained early durin...
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Open AccessShallow-level defect passivation by 6H perovskite polytype for highly efficient and stable perovskite solar cells
The power conversion efficiency of perovskite solar cells continues to increase. However, defects in perovskite materials are detrimental to their carrier dynamics and structural stability, ultimately limiting...
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Open AccessCharacterization, comparison, and phylogenetic analyses of chloroplast genomes of Euphorbia species
The genus Euphorbia (Euphorbiaceae) has near-cosmopolitan distribution and serves as a significant resource for both ornamental and medicinal purposes. Despite its economic importance, Euphorbia's taxonomy has lo...
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Open AccessToF-SIMS evaluation of PEG-related mass peaks and applications in PEG detection in cosmetic products
Polyethylene glycols (PEGs) are used in industrial, medical, health care, and personal care applications. The cycling and disposal of synthetic polymers like PEGs pose significant environmental concerns. Detec...
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Open AccessDosimetric analysis of six whole-breast irradiation techniques in supine and prone positions
In breast cancer radiation therapy, minimizing radiation-related risks and toxicity is vital for improving life expectancy. Tailoring radiotherapy techniques and treatment positions can reduce radiation doses ...
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Open AccessFree-standing two-dimensional ferro-ionic memristor
Two-dimensional (2D) ferroelectric materials have emerged as significant platforms for multi-functional three-dimensional (3D) integrated electronic devices. Among 2D ferroelectric materials, ferro-ionic CuInP2S6
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Open AccessA dual spin-controlled chiral two-/three-dimensional perovskite artificial leaf for efficient overall photoelectrochemical water splitting
The oxygen evolution reaction, which involves high overpotential and slow charge-transport kinetics, plays a critical role in determining the efficiency of solar-driven water splitting. The chiral-induced spin...
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Open AccessStatin prevents cancer development in chronic inflammation by blocking interleukin 33 expression
Chronic inflammation is a major cause of cancer worldwide. Interleukin 33 (IL-33) is a critical initiator of cancer-prone chronic inflammation; however, its induction mechanism by environmental causes of chron...
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Open AccessDevelopment of a novel non-invasive biomarker panel for hepatic fibrosis in MASLD
Accurate non-invasive biomarkers to diagnose metabolic dysfunction-associated steatotic liver disease (MASLD)-related fibrosis are urgently needed. This study applies a translational approach to develop a bloo...
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Open AccessA multimodal machine learning model for predicting dementia conversion in Alzheimer’s disease
Alzheimer’s disease (AD) accounts for 60–70% of the population with dementia. Mild cognitive impairment (MCI) is a diagnostic entity defined as an intermediate stage between subjective cognitive decline and de...
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Open AccessMachine learning models for predicting early hemorrhage progression in traumatic brain injury
This study explores the progression of intracerebral hemorrhage (ICH) in patients with mild to moderate traumatic brain injury (TBI). It aims to predict the risk of ICH progression using initial CT scans and i...
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Open AccessSpatio-temporal characterization of drought variability in data-scarce regions using global precipitation data: a case study in Cauto river basin, Cuba
Drought is considered the most severe water-related disaster in the Cauto river basin, which is the longest river and the main agricultural producer in Cuba. Better understanding of drought characteristics is ...
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Open AccessDevelo** centrifugal force real-time digital PCR for detecting extremely low DNA concentration
Digital PCR (dPCR) is a technique for absolute quantification of nucleic acid molecules. To develop a dPCR technique that enables more accurate nucleic acid detection and quantification, we established a novel...
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Open AccessSafety, immunogenicity and efficacy of the self-amplifying mRNA ARCT-154 COVID-19 vaccine: pooled phase 1, 2, 3a and 3b randomized, controlled trials
Combination of waning immunity and lower effectiveness against new SARS-CoV-2 variants of approved COVID-19 vaccines necessitates new vaccines. We evaluated two doses, 28 days apart, of ARCT-154, a self-amplif...
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Open AccessSpin-orbit-splitting-driven nonlinear Hall effect in NbIrTe4
The Berry curvature dipole (BCD) serves as a one of the fundamental contributors to emergence of the nonlinear Hall effect (NLHE). Despite intense interest due to its potential for new technologies reaching be...
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Open AccessRevealing the three-dimensional arrangement of polar topology in nanoparticles
In the early 2000s, low dimensional ferroelectric systems were predicted to have topologically nontrivial polar structures, such as vortices or skyrmions, depending on mechanical or electrical boundary conditi...
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Open AccessWide-incident-angle, polarization-independent broadband-absorption metastructure without external resistive elements by using a trapezoidal structure
The absorption of electromagnetic waves in a broadband frequency range with polarization insensitivity and incidence-angle independence is greatly needed in modern technology applications. Many structures base...
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Open AccessDual-channel fluorescent sensors based on chitosan-coated Mn-doped ZnS micromaterials to detect ampicillin
The global threat of antibiotic resistance has increased the importance of the detection of antibiotics. Conventional methods to detect antibiotics are time-consuming and require expensive specialized equipmen...
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Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1
Phosphatidylcholine and phosphatidylethanolamine, the two most abundant phospholipids in mammalian cells, are synthesized de novo by the Kennedy pathway from choline and ethanolamine, respectively1–6. Despite the...
