15 Result(s)
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Article
Open AccessDelineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses
Acral melanoma (AM) is a rare subtype of melanoma characterized by a high incidence of lymph node (LN) metastasis, a critical factor in tumor dissemination and therapeutic decision-making. Here, we employ sing...
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Open AccessIntegrating terrestrial and aquatic ecosystems to constrain estimates of land-atmosphere carbon exchange
In this Perspective, we put forward an integrative framework to improve estimates of land-atmosphere carbon exchange based on the accumulation of carbon in the landscape as constrained by its lateral export th...
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Open AccessDiel variations in planktonic ciliate community structure in the northern South China Sea and tropical Western Pacific
Though diel variations are geographically widespread phenomena among phytoplankton and zooplankton, knowledge is limited regarding diel variations in planktonic ciliate (microzooplankton) community structure. ...
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Open AccessGSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis
Pyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation of inflammation. To test the hypothesis that GSDME-mediated pyroptosis aggravates the progression of atherosclerosis, we gene...
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Open AccessEGFR, HER2, and HER3 protein expression in paired primary tumor and lymph node metastasis of colorectal cancer
Due to the difficulty in sampling of metastatic tumors, patient selection is commonly based on results of primary tumor samples when metastatic samples are not available. However, due to tumor heterogeneity, m...
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Open AccessCoexistence of valley polarization and Chern insulating states in MoS2 monolayers with n-p codo**
The electronic and topological properties of MoS2 monolayers with n-p codo** effect are investigated by using first-principles calculations. Two types of the doped Nb atoms play the roles of the p-type and n-ty...
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Open AccessSingle-molecule long-read sequencing facilitates shrimp transcriptome research
Although shrimp are of great economic importance, few full-length shrimp transcriptomes are available. Here, we used Pacific Biosciences single-molecule real-time (SMRT) long-read sequencing technology to gene...
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Open AccessAutosomal DIPs for population genetic structure and differentiation analyses of Chinese **njiang Kyrgyz ethnic group
In recent years, deletion and insertion polymorphisms (DIPs) were treated as a novel complementary tool with huge potential for forensic applications. In this study, we utilized 30 DIP loci to make a comprehen...
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Article
Open AccessmiR-103 promotes endothelial maladaptation by targeting lncWDR59
Blood flow at arterial bifurcations and curvatures is naturally disturbed. Endothelial cells (ECs) fail to adapt to disturbed flow, which transcriptionally direct ECs toward a maladapted phenotype, characteriz...
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Open AccessPurification and characterization of a novel phloretin-2′-O-glycosyltransferase favoring phloridzin biosynthesis
Phloretin-2′-O-glycosyltransferase (P2′GT) catalyzes the last glycosylation step in the biosynthesis of phloridzin that contributes to the flavor, color and health benefits of apples and processed apple products....
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Article
Open AccessCorrection: Corrigendum: Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4
Nature Communications 7: Article number: 10521 (2016); Published: 3 February 2016; Updated: 7 June 2016 This Article contains an error in the dose of LNA-target site blocker oligonucleotides that was administe...
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Open AccessOne-pot conversion of disaccharide into 5-hydroxymethylfurfural catalyzed by imidazole ionic liquid
Conversion of carbohydrate into 5-hydroxymethylfurfural (5- HMF), a versatile, key renewable platform compound is regarded as an important transformation in biomass-derived carbohydrate chemistry. A variety of...
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Article
Open AccessEndothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4
MicroRNAs regulate the maladaptation of endothelial cells (ECs) to naturally occurring disturbed blood flow at arterial bifurcations resulting in arterial inflammation and atherosclerosis in response to hyperl...
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Open AccessEvidence for the expression of abundant microRNAs in the locust genome
Substantial accumulation of neutral sequences accounts for genome size expansion in animal genomes. Numerous novel microRNAs (miRNAs), which evolve in a birth and death manner, are considered evolutionary neut...
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Article
Open AccessCarboxyl-modified single-walled carbon nanotubes negatively affect bacterial growth and denitrification activity
Single-walled carbon nanotubes (SWNTs) have been used in a wide range of fields and the surface modification via carboxyl functionalization can further improve their physicochemical properties. However, whethe...
