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Article
Open AccessTudor-SN promotes cardiomyocyte proliferation and neonatal heart regeneration through regulating the phosphorylation of YAP
The neonatal mammalian heart exhibits considerable regenerative potential following injury through cardiomyocyte proliferation, whereas mature cardiomyocytes withdraw from the cell cycle and lose regenerative ...
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Article
Open AccessOral administration of probiotic spore ghosts for efficient attenuation of radiation-induced intestinal injury
Radiation-induced intestinal injury is the most common side effect during radiotherapy of abdominal or pelvic solid tumors, significantly impacting patients’ quality of life and even resulting in poor prognosi...
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Article
Open AccessJMJD3 regulate H3K27me3 modification via interacting directly with TET1 to affect spermatogonia self-renewal and proliferation
In epigenetic modification, histone modification and DNA methylation coordinate the regulation of spermatogonium. Not only can methylcytosine dioxygenase 1 (TET1) function as a DNA demethylase, converting 5-me...
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Article
Open AccessVascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia
Vascular smooth muscle cell (VSMC) proliferation is the leading cause of vascular stenosis or restenosis. Therefore, investigating the molecular mechanisms and pivotal regulators of the proliferative VSMC phen...
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Article
Open AccessA novel c-Met/TRK inhibitor 1D228 efficiently inhibits tumor growth by targeting angiogenesis and tumor cell proliferation
Multiple tumors are synergistically promoted by c-Met and TRK, and blocking their cross-signalling pathway may give better effects. In this study, we developed a tyrosine kinase inhibitor 1D228, which exhibite...
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Article
Open AccessNon-thermal evolution of dense plasmas driven by intense x-ray fields
The advent of x-ray free-electron lasers has enabled a range of new experimental investigations into the properties of matter driven to extreme conditions via intense x-ray-matter interactions. The femtosecond...
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Article
Open AccessArginase: shedding light on the mechanisms and opportunities in cardiovascular diseases
Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform significant roles in the regulation o...
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Article
Open AccessvChecker: an application-level demand-based co-scheduler for improving the performance of parallel jobs in Xen
Big data analysis requires the speedup of parallel computing. However, in the virtualized systems, the power of parallel computing is not fully exploited due to the limit of current VMM schedulers. Xen, one of...
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Article
Open AccessContention-aware prediction for performance impact of task co-running in multicore computers
In this paper, we investigate the influential factors that impact on the performance when the tasks are co-running on a multicore computers. Further, we propose the machine learning-based prediction framework ...
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Article
Open AccessDevelopment of a biomechanical model for dynamic occlusal stress analysis
The use of traditional finite element method (FEM) in occlusal stress analysis is limited due to the complexity of musculature simulation. The present purpose was to develop a displacement boundary condition (...
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Article
Open Access4210 Da and 1866 Da polypeptides as potential biomarkers of liver disease progression in hepatitis B virus patients
HBV infection is recognized as a serious global health problem, and hepatitis B virus infection is a complicated chronic disease leading to liver cirrhosis (LC) and hepatocellular carcinoma (HCC). New biochemi...
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Article
Open AccessEffect of sowing proportion on above- and below-ground competition in maize–soybean intercrops
The relative contribution of above- and below-ground competition to crop yield under intercrop** systems is critical to understanding the mechanisms of improved yield. Changes in the content of above- and be...
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Article
Open AccessGenetic expression and mutational profile analysis in different pathologic stages of hepatocellular carcinoma patients
The clinical pathologic stages (stage I, II, III-IV) of hepatocellular carcinoma (HCC) are closely linked to the clinical prognosis of patients. This study aims at investigating the gene expression and mutatio...
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Article
Open AccessDifferential genetic mutations of ectoderm, mesoderm, and endoderm-derived tumors in TCGA database
In terms of biological behavior, gene regulation, or signaling pathways, there is a certain similarity between tumorigenesis and embryonic development of humans. Three germ layer structure exhibits the distinc...
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Article
Open AccessHarnessing C/N balance of Chromochloris zofingiensis to overcome the potential conflict in microalgal production
Accumulation of high-value products in microalgae is not conducive with rapid cell growth, which is the potential conflict in microalgal production. Overcoming such conflict faces numerous challenges in compre...
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Article
Open AccessRole of cytarabine in paediatric acute promyelocytic leukemia treated with the combination of all-trans retinoic acid and arsenic trioxide: a randomized controlled trial
The combination of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) has been suggested to be safe and effective for adult acute promyelocytic leukaemia (APL). As of 2010, the role of cytarabine (Ara-C...
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Chapter and Conference Paper
vGrouper: Optimizing the Performance of Parallel Jobs in Xen by Increasing Synchronous Execution of Virtual Machines
Xen is one of the most popular virtualization platforms nowadays, which has been broadly used by the industry. Credit scheduler, the default scheduler of Xen, was initially designed for serial jobs, which achi...
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Chapter and Conference Paper
Data Fine-Pruning: A Simple Way to Accelerate Neural Network Training
The training process of a neural network is the most time-consuming procedure before being deployed to applications. In this paper, we investigate the loss trend of the training data during the training proces...
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Article
Open AccessEnhancement of porcine intramuscular fat content by overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase in skeletal muscle
Intramuscular fat (IMF) content has been generally recognized as a desirable trait in pork meat because of its positive effect on eating quality. An effective approach to enhance IMF content in pork is the gen...
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Article
Open AccessMutation analysis of Chinese sporadic congenital sideroblastic anemia by targeted capture sequencing
Congenital sideroblastic anemias (CSAs) comprise a group of heterogenous genetic diseases that are caused by the mutation of various genes involved in heme biosynthesis, iron-sulfur cluster biogenesis, or mito...
