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Article
Open AccessPKM2 aggregation drives metabolism reprograming during aging process
While protein aggregation’s association with aging and age-related diseases is well-established, the specific proteins involved and whether dissolving them could alleviate aging remain unclear. Our research ad...
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Article
Open AccessAuthor Correction: Brain clearance is reduced during sleep and anesthesia
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Article
Open AccessFeasibility of CT attenuation values in distinguishing acute ischemic stroke, old cerebral infarction and leukoaraiosis
This study aimed to investigate the feasibility of using computed tomography (CT) attenuation values to differentiate hypodense brain lesions, specifically acute ischemic stroke (AIS) from asymmetric leukoarai...
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Article
Open AccessSRSF9 promotes cell proliferation and migration of glioblastoma through enhancing CDK1 expression
Glioblastoma (GBM) is a highly aggressive and prevalent brain tumor that poses significant challenges in treatment. SRSF9, an RNA-binding protein, is essential for cellular processes and implicated in cancer p...
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Article
Open AccessBrain clearance is reduced during sleep and anesthesia
It has been suggested that the function of sleep is to actively clear metabolites and toxins from the brain. Enhanced clearance is also said to occur during anesthesia. Here, we measure clearance and movement ...
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Article
Inherited KDM6AA649T facilitates tumor-immune escape and exacerbates colorectal signet-ring cell carcinoma outcomes
Childhood onset of colorectal signet-ring cell carcinoma (CR-SRCC) is extremely rare and featured as highly malignant with poor prognosis. Here we reported a CR-SRCC case of 11-year-old boy with a novel inheri...
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Article
Open AccessIdentification of symptom clusters and sentinel symptoms during the first cycle of chemotherapy in patients with lung cancer
To identify symptom clusters (SCs) in patients with lung cancer who are undergoing initial chemotherapy and to identify the sentinel symptoms of each SC.
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Article
Open AccessChallenges in blood transfusion caused by anti-Hr0: A rare case of D-- Phenotype in Asia Abstract
D–Phenotype is linked to abnormal expression of RHCE gene. Consequently, individuals with this condition may develop antibodies against high-prevalence Rh antigens when exposed to a normal Rh phenotype, leading ...
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Article
Investigating the role of TGF-β and BDNF in cancer-related depression: a primary cross-sectional study
Cancer-related depression is a well-documented condition that significantly impacts long-term quality of life. Brain-derived neurotrophic factor (BDNF), a neurotrophin essential for neurogenesis and neuronal p...
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Article
Industrial Carbon Emission Distribution and Regional Joint Emission Reduction: A Case Study of Cities in the Pearl River Basin, China
China’s low-carbon development path will make significant contributions to achieving global sustainable development goals. Due to the diverse natural and economic conditions across different regions in China, ...
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Article
Inhibition of TLR4/NF-κB pathway and endoplasmic reticulum stress by overexpressed S100A4 ameliorates retinal ischemia-reperfusion injury of mice
Retinal ischemia exists in various ischemic retinopathies including glaucoma, contributing to the death of retinal neurons. Calcium binding protein S100A4 is important in tumors, and our previous study found t...
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Article
Canagliflozin regulates metabolic reprogramming in diabetic kidney disease by inducing fasting-like and aestivation-like metabolic patterns
Sodium–glucose co-transporter 2 (SGLT2) inhibitors (SGLT2i) are antihyperglycaemic drugs that protect the kidneys of individuals with type 2 diabetes mellitus. However, the underlying mechanisms mediating the ...
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Article
Open AccessYME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditions
The senescence of renal tubular epithelial cells (RTECs) is crucial in the progression of diabetic kidney disease (DKD). Accumulating evidence suggests a close association between insufficient mitophagy and RT...
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Article
Open AccessExploring the role of mitochondrial-associated and peripheral neuropathy genes in the pathogenesis of diabetic peripheral neuropathy
Diabetic peripheral neuropathy (DPN) is a prevalent and serious complication of diabetes mellitus, impacting the nerves in the limbs and leading to symptoms like pain, numbness, and diminished function. While ...
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Article
Open AccessDevelo** a psychological care competences framework for nurses in China: a mixed methods study
With social transformation, rapid economic development and deepening awareness of psychological health in China, people’s demand for psychological health services is becoming increasingly urgent. A key challen...
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Article
Family of boost and buck-boost converters with continuous input current and reduced semiconductor count for hybrid energy systems
Power converters are the key link to realize energy transfer from hybrid energy systems (HESs) to loads. In this paper, a family of boost and buck-boost DC-DC converters that is highly desirable for HESs is pr...
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Article
Open AccessStructural and functional insights into the lipid regulation of human anion exchanger 2
Anion exchanger 2 (AE2) is an electroneutral Na+-independent Cl-/HCO3- exchanger belongs to the SLC4 transporter family. The widely expressed AE2 participates in a variety of physiological processes, including tr...
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Chapter and Conference Paper
Machine Learning for Time-to-Event Prediction and Survival Clustering: A Review from Statistics to Deep Neural Networks
Survival analysis is a statistical method used in computational biology to investigate the time until the occurrence of an event of interest, such as death or disease recurrence. It plays a crucial role in ana...
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Article
Celastrus orbiculatus extract suppresses gastric cancer stem cells through the TGF-β/Smad signaling pathway
Cancer stem cells (CSCs) are the primary source of tumor recurrence and chemoresistance, which complicates tumor treatment and has a significant impact on poor patient prognosis. Therefore, the discovery of in...
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Article
Open AccessClinical observational study on the efficacy of induction chemotherapy sequential concurrent radiotherapy combined with targeted therapy in patients with locally advanced EGFR-positive nasopharyngeal carcinoma: prediction model construction and efficacy testing
To establish a nomogram for prediction of prognosis in EGFR-positive advanced nasopharyngeal carcinoma (NPC) patients who were treated with induction chemotherapy (IC) and concurrent chemoradiotherapy (CCRT). ...
