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  1. Article

    Open Access

    Promising therapeutic aspects in human genetic imprinting disorders

    Genomic imprinting is an epigenetic phenomenon of monoallelic gene expression pattern depending on parental origin. In humans, congenital imprinting disruptions resulting from genetic or epigenetic mechanisms ...

    Yunqi Chao, Yifang Qin, **nyi Zou, **angzhi Wang, Chenxi Hu… in Clinical Epigenetics (2022)

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  2. Article

    Open Access

    Modeling transmission of SARS-CoV-2 Omicron in China

    Having adopted a dynamic zero-COVID strategy to respond to SARS-CoV-2 variants with higher transmissibility since August 2021, China is now considering whether, and for how long, this policy can remain in plac...

    Jun Cai, **aowei Deng, Juan Yang, Kaiyuan Sun, Hengcong Liu… in Nature Medicine (2022)

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  3. Article

    Open Access

    Global landscape of SARS-CoV-2 genomic surveillance and data sharing

    Genomic surveillance has shaped our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. We performed a global landscape analysis on SARS-CoV-2 genomic surveillance and genom...

    Zhiyuan Chen, Andrew S. Azman, **nhua Chen, Junyi Zou, Yuyang Tian… in Nature Genetics (2022)

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  4. No Access

    Article

    Identification of genetic variants in m6A modification genes associated with pancreatic cancer risk in the Chinese population

    N6-Methyladenosine (m6A) is the most prevalent modification of RNA in eukaryotes, and is associated with many cellular processes and even the development of cancers. We hypothesized that single-nucleotide polymor...

    **ting Ying, Yao Li, Nan Yang, **aoyang Wang, Haoxue Wang… in Archives of Toxicology (2021)

  5. No Access

    Article

    Functional characterization of a low-frequency V1937I variant in FASN associated with susceptibility to esophageal squamous cell carcinoma

    Metabolic reprogramming has been regarded as one of the core hallmarks of cancer and increased de novo fatty acid synthesis has been documented in multiple tumors including esophageal squamous cell carcinoma (...

    **aoyang Wang, Jianbo Tian, Qianyu Zhao, Nan Yang, **ting Ying… in Archives of Toxicology (2020)

  6. No Access

    Article

    Three functional variants were identified to affect RPS24 expression and significantly associated with risk of colorectal cancer

    GWAS-identified 10q22.3 loci with lead SNP rs704017 are significantly associated with CRC risk in both Asian and European populations. However, the functional mechanism of this region is unclear. In this study...

    Danyi Zou, Hongli Zhang, Juntao Ke, Jiaoyuan Li, Ying Zhu… in Archives of Toxicology (2020)

  7. No Access

    Article

    Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma

    Genome-wide association studies have identified common variants associated with risk of esophageal squamous cell carcinoma (ESCC). However, these common variants cannot explain all heritability of ESCC. Here w...

    Jiang Chang, Rong Zhong, Jianbo Tian, Jiaoyuan Li, Kan Zhai, Juntao Ke… in Nature Genetics (2018)