15 Result(s)

Article

NEAT1_1 confers gefitinib resistance in lung adenocarcinoma through promoting AKR1C1-mediated ferroptosis defence

Gefitinib is one of the most extensively utilized epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) for treating advanced lung adenocarcinoma (LUAD) patients harboring EGFR mutation. Howe...

Shuman Zhen, Yunlong Jia, Yan Zhao, Jiali Wang, Boyang Zheng… in Cell Death Discovery (2024)

Article

Tet methylcytosine dioxygenase 2 (TET2) deficiency elicits EGFR-TKI (tyrosine kinase inhibitors) resistance in non-small cell lung cancer

Despite epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) have shown remarkable efficacy in patients with EGFR-mutant non-small cell lung cancer (NSCLC), acquired resistance inevitably deve...

Jian Zhang, Kejia Zhao, Wen**g Zhou, Ran Kang… in Signal Transduction and Targeted Therapy (2024)

Article

Akkermansia muciniphila Improves Depressive-Like Symptoms by Modulating the Level of 5-HT Neurotransmitters in the Gut and Brain of Mice

Accumulating evidence has suggested that the gut microbiome plays an important role in depression. Akkermansia muciniphila (AKK), a next-generation probiotic, shows a beneficial effect on immune and metabolic hom...

Huijuan Guo, **nxu Liu, Ti Chen, ** Wang, **aojie Zhang in Molecular Neurobiology (2024)

Article

Predicting assembly mode of membraneless organelles by a FRET-based crowding sensor

Feng Chen, Siyuan Shen, Xu Cao, Liang Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

Long non-coding RNA SNHG10 upregulates BIN1 to suppress the tumorigenesis and epithelial–mesenchymal transition of epithelial ovarian cancer via sponging miR-200a-3p

Epithelial ovarian cancer (EOC) is one of the most frequent and fatal gynecologic malignant tumors resulting in an unsatisfying prognosis. Long non-coding RNAs (lncRNAs) play pivotal roles in the tumorigenesis...

Wei Lv, Yunlong Jia, Jiali Wang, Yuqing Duan, Xuexiao Wang… in Cell Death Discovery (2022)

Article

Long noncoding RNA DGCR5 involves in tumorigenesis of esophageal squamous cell carcinoma via SRSF1-mediated alternative splicing of Mcl-1

Long noncoding RNAs (lncRNAs) emerge as essential roles in the regulation of alternative splicing (AS) in various malignancies. Serine- and arginine-rich splicing factor 1 (SRSF1)-mediated AS events are the mo...

Yuqing Duan, Yunlong Jia, Jiali Wang, Tianxu Liu, Zishuo Cheng… in Cell Death & Disease (2021)

Article

HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture

Although combination antiretroviral therapy (cART) has improved the health of millions of those living with HIV-1 (Human Immunodeficiency Virus, Type 1), the penetration into the central nervous system (CNS) o...

Guoku Hu, Fang Niu, Ke Liao, Palsamy Periyasamy… in Journal of Neuroimmune Pharmacology (2020)

Article

miR-410 induces both epithelial–mesenchymal transition and radioresistance through activation of the PI3K/mTOR pathway in non-small cell lung cancer

Radiotherapy remains one of the major treatments for non-small cell lung cancer (NSCLC) patients; whereas intrinsic or acquired radioresistance limits its efficacy. Nevertheless, most studies so far have only ...

Yue Yuan, Hu Liao, Qiang Pu, **xian Ke… in Signal Transduction and Targeted Therapy (2020)

Article

CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC

Bridging integrator 1 (BIN1) has showed outstanding tumor-suppressive potential via inhibiting c-MYC-mediated tumorigenesis. However, a frequent phosphorylation of c-MYC at Ser-62 site could block the BIN1/c-M...

**angyu Zhang, Jiali Wang, Yunlong Jia, Tianxu Liu… in Cancer Cell International (2019)

Article

LncRNA TTN-AS1 promotes migration, invasion, and epithelial mesenchymal transition of lung adenocarcinoma via sponging miR-142-5p to regulate CDK5

Emerging evidence suggests that long noncoding RNA (lncRNA) plays pivotal roles in regulating various biological process in human cancers. Titin-antisense RNA1 (TTN-AS1) has been regarded as a tumor promoting ...

Yunlong Jia, Yuqing Duan, Tianxu Liu, Xuexiao Wang, Wei Lv… in Cell Death & Disease (2019)

Article

WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is a lymphoid malignancy caused by the oncogenic transformation of immature T-cell progenitors with poor outcomes. WP1130 has shown potent activity against a variety...

Hao Luo, Bo **g, Yu **a, Yugen Zhang, Meng Hu, Haiyan Cai… in Cancer Cell International (2019)

Article

MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression

MicroRNAs (miRNAs) have been demonstrated to modulate cellular processes in the liver. However, the role of miRNAs in liver fibrosis is poorly understood. Because the activation of hepatic stellate cells (HSCs...

Li** Ma, **aoxue Yang, Rong Wei, Tinghong Ye, Jian-Kang Zhou… in Cell Death & Disease (2018)

Article

Neurons generated from carcinoma stem cells support cancer progression

Recent evidences show that nervous system acts as a crucial part of cancer microenvironment. Infiltration of nerve fibers into cancer microenvironment has an important active role in cancer progression. The st...

Ran Lu, Chuanwen Fan, Wenqi Shangguan, Yuan Liu… in Signal Transduction and Targeted Therapy (2017)

Article

ZNF32 contributes to the induction of multidrug resistance by regulating TGF-β receptor 2 signaling in lung adenocarcinoma

Multidrug resistance (MDR) is one of the most important contributors to the high mortality of cancer and remains a major concern. We previously found that zinc finger protein 32 (ZNF32), an important transcrip...

Jun Li, Jie Ao, Kai Li, Jie Zhang, Yanyan Li, Le Zhang, Yuyan Wei… in Cell Death & Disease (2016)

Article

Bone marrow-derived mesenchymal stem cells differentiate into nerve-like cells in vitro after transfection with brain-derived neurotrophic factor gene

Bone marrow-derived mesenchymal stem cells can differentiate into a variety of adult cells. Brain-derived neurotrophic factor (BDNF) is briefly active during differentiation and induces mesenchymal stem cells ...

Qianxu Liu, Guangui Cheng, Zhiwei Wang… in In Vitro Cellular & Developmental Biology … (2015)