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Article
Open AccessDifferential protein analysis of saline-alkali promoting the oil accumulation in Nitzschia palea
The increasingly severe salinization of the aquatic environment has led to serious damage to the habitats of aquatic organisms. Benthic diatoms are commonly employed as indicator species for assessing water qu...
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Article
New technologies provide more metabolic engineering strategies for bioethanol production in Zymomonas mobilis
Bioethanol has been considered as a potentially renewable energy source, and metabolic engineering plays an important role in the production of biofuels. As an efficient ethanol-producing bacterium, Zymomonas mob...
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Article
Comparison of two matrix-assisted laser desorption ionization-time of flight mass spectrometry systems for the identification of clinical filamentous fungi
Infections caused by filamentous fungi have become a health concern, and require rapid and accurate identification in order for effective treatment of the pathogens. To compare the performance of two MALDI-TOF...
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Article
Antimycobacterial activity of five efflux pump inhibitors against Mycobacterium tuberculosis clinical isolates
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Article
Study of efflux pump gene expression in rifampicin-monoresistant Mycobacterium tuberculosis clinical isolates
Rifampicin (RIF) resistance is a risk factor for poor outcome in tuberculosis (TB). In Mycobacterium tuberculosis, both target gene mutation and efflux pumps have major roles in the resistance to anti-TB drugs. T...
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Article
Iron and zinc binding activity of Escherichia coli topoisomerase I homolog YrdD
YrdD, a homolog of the C-terminal zinc-binding region of Escherichia coli topoisomerase I, is highly conserved among proteobacteria and enterobacteria. However, the function of YrdD remains elusive. Here we repor...
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Article
Competition of zinc ion for the [2Fe–2S] cluster binding site in the diabetes drug target protein mitoNEET
Human mitochondrial protein mitoNEET is a novel target of type II diabetes drug pioglitazone, and contains a redox active [2Fe–2S] cluster that is hosted by a unique ligand arrangement of three cysteine and on...
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Article
Escherichia coli topoisomerase I is an iron and zinc binding protein
Escherichia coli topoisomerase I (TopA) cleaves and rejoins one strand of double-stranded DNA to relax the negatively supercoiled DNA. Structurally, TopA contains an N-terminal catalytic fragment and a C-terminal...