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Open AccessPyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress
Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive. Here, we identify that proline synthe...
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Open Accessα-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure
The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac structure and contraction. However, the mechanism regulating this interaction in normal and failing hearts remains unk...
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Open AccessResveratrol rescues cutaneous radiation-induced DNA damage via a novel AMPK/SIRT7/HMGB1 regulatory axis
Cutaneous radiation injury (CRI) interrupts the scheduled process of radiotherapy and even compromises the life quality of patients. However, the current clinical options for alleviating CRI are relatively lim...
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Open AccessLINC00858 stabilizes RAN expression and promotes metastasis of gastric cancer
Metastasis constitutes one of the major causes of tumor-related death in gastric cancer (GC), and understanding key events in the initiation of this phenotypic switch may provide therapeutic opportunities. Lon...
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Open AccessThe role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) has been a huge threat for people's health and finding effective target therapy is urgent and important. WWP2, as one of E3 ubiquitin ligase, is involved in many biological p...
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Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function
The AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis. Although much has been learned on how low energy status and glucose starvation activate AMPK, how AMPK activity is properly...
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Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells
RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms. Here, we demonstrate that DROSHA interacts with β-Catenin to transactivate STC1 in an RNA c...
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Open AccessThe 2nd International Conference on Water Resource and Environment (WRE 2016)
01 The eco-toxicological effects of cadmium stress on five ornamental plants
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Open AccessErratum to: Molecular characteristics of the ompA gene of serotype B Chlamydia trachomatis in Qinghai Tibetan primary school students
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Open AccessStudy of infectious conjunctivitis among children in rural areas of Qinghai province
Infectious conjunctivitis is no longer a common eye disease in cities and developed areas, but in remote mountainous regions of China where living conditions are relatively under-developed, the occurrence of i...
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Open AccessEtiological characteristics of chlamydia trachoma conjunctivitis of Primary Boarding School students in the Qinghai Tibetan area
The aim of this study was to investigate the etiological characteristics of Chlamydia trachomatis conjunctivitis among resident students at primary schools in the Qinghai Tibetan area in order to understand the d...
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Open AccessMolecular characteristics of the ompA gene of serotype B Chlamydia trachomatis in Qinghai Tibetan primary school students
To study the molecular characteristics of Chlamydia trachomatis, the major outer membrane protein gene (ompA) of C. trachomatis from primary school students with trachoma residing in the Qinghai Tibetan area was ...
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Antimycobacterial activity of five efflux pump inhibitors against Mycobacterium tuberculosis clinical isolates
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Study of efflux pump gene expression in rifampicin-monoresistant Mycobacterium tuberculosis clinical isolates
Rifampicin (RIF) resistance is a risk factor for poor outcome in tuberculosis (TB). In Mycobacterium tuberculosis, both target gene mutation and efflux pumps have major roles in the resistance to anti-TB drugs. T...
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Concentrations, turnover rates and fluxes of polyamines in coastal waters of the South Atlantic Bight
Polyamines are short-chain aliphatic compounds containing multiple amine groups. They are important components of the cytosol of eukaryotes and are present at mmol L−1 concentrations inside phytoplankton cells, w...
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Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death
Cytotoxic lymphocytes are key players in the orchestration of immune response and elimination of defective cells. We have previously reported that natural killer (NK) cells enter target tumor cells, leading to...
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Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis
Alterations in oxidative phosphorylation resulting from mitochondrial dysfunction have long been hypothesized to be involved in tumorigenesis. Mitochondria have recently been shown to play an important role in...
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Open AccesscTFbase: a database for comparative genomics of transcription factors in cyanobacteria
Comprehensive identification and classification of the transcription factors (TFs) in a given genome is an important aspect in understanding transcriptional regulatory networks of a specific organism. Cyanobac...