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  1. Article

    Open Access

    Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress

    Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive. Here, we identify that proline synthe...

    Bai Cui, Bin He, Yan** Huang, Cenxin Wang, Huandong Luo in Cell Death & Disease (2023)

  2. Article

    Open Access

    α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure

    The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac structure and contraction. However, the mechanism regulating this interaction in normal and failing hearts remains unk...

    Nai** Zhang, Ying Zhang, Jiaqi Xu, Pengbo Wang, Boquan Wu, Saien Lu in Cell Research (2023)

  3. Article

    Open Access

    Resveratrol rescues cutaneous radiation-induced DNA damage via a novel AMPK/SIRT7/HMGB1 regulatory axis

    Cutaneous radiation injury (CRI) interrupts the scheduled process of radiotherapy and even compromises the life quality of patients. However, the current clinical options for alleviating CRI are relatively lim...

    Yi **, **ngyuan Liu, **aoting Liang, Jiabin Liu, Jieyu Liu in Cell Death & Disease (2023)

  4. Article

    Open Access

    LINC00858 stabilizes RAN expression and promotes metastasis of gastric cancer

    Metastasis constitutes one of the major causes of tumor-related death in gastric cancer (GC), and understanding key events in the initiation of this phenotypic switch may provide therapeutic opportunities. Lon...

    Yunxin Lu, Qi Meng, Long Bai, Ruobing Wang, Yong Sun, Jiaqi Li, Jun Fan in Biology Direct (2022)

  5. Article

    Open Access

    The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia

    Acute lymphoblastic leukemia (ALL) has been a huge threat for people's health and finding effective target therapy is urgent and important. WWP2, as one of E3 ubiquitin ligase, is involved in many biological p...

    **nxin Lu, **nyue Huang, Haiqi Xu, Saien Lu, Shilong You, Jiaqi Xu in Cell Death Discovery (2022)

  6. No Access

    Article

    Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function

    The AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis. Although much has been learned on how low energy status and glucose starvation activate AMPK, how AMPK activity is properly...

    **ang Xu, Guang** Ding, Caizhi Liu, Yuhan Ding, **aoxin Chen in Cell Research (2022)

  7. No Access

    Article

    Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells

    RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms. Here, we demonstrate that DROSHA interacts with β-Catenin to transactivate STC1 in an RNA c...

    Fei Peng, Jie Xu, Bai Cui, Qilan Liang, Sai Zeng, Bin He, Hong Zou in Cell Research (2021)

  8. Article

    Open Access

    The 2nd International Conference on Water Resource and Environment (WRE 2016)

    01 The eco-toxicological effects of cadmium stress on five ornamental plants

    Zhouli Liu, Wei Chen, **ngyuan He, Shuai Yu, Weihang Ding, Jianjun Liu in BMC Ecology (2016)

  9. Article

    Open Access

    Erratum to: Molecular characteristics of the ompA gene of serotype B Chlamydia trachomatis in Qinghai Tibetan primary school students

    Xue Li, Shaoya Zhang, Qingfeng Liang, Mei Wang, Ailian Hu in Science China Life Sciences (2016)

  10. Article

    Open Access

    Study of infectious conjunctivitis among children in rural areas of Qinghai province

    Infectious conjunctivitis is no longer a common eye disease in cities and developed areas, but in remote mountainous regions of China where living conditions are relatively under-developed, the occurrence of i...

    Qingfeng Liang, **nxin Lu, Mei Wang, Lei Tian, Antoine Labbé in Science China Life Sciences (2016)

  11. Article

    Open Access

    Etiological characteristics of chlamydia trachoma conjunctivitis of Primary Boarding School students in the Qinghai Tibetan area

    The aim of this study was to investigate the etiological characteristics of Chlamydia trachomatis conjunctivitis among resident students at primary schools in the Qinghai Tibetan area in order to understand the d...

    Mei Wang, **nxin Lu, Ailian Hu, Mingxin Zhang, Xue Li in Science China Life Sciences (2016)

  12. Article

    Open Access

    Molecular characteristics of the ompA gene of serotype B Chlamydia trachomatis in Qinghai Tibetan primary school students

    To study the molecular characteristics of Chlamydia trachomatis, the major outer membrane protein gene (ompA) of C. trachomatis from primary school students with trachoma residing in the Qinghai Tibetan area was ...

    Xue Li, Shaoya Zhang, Qingfeng Liang, Mei Wang, Ailian Hu in Science China Life Sciences (2016)

  13. Article

    Antimycobacterial activity of five efflux pump inhibitors against Mycobacterium tuberculosis clinical isolates

    Guilian Li, **grui Zhang, Chao Li, Qian Guo, Yi Jiang in The Journal of Antibiotics (2016)

  14. Article

    Study of efflux pump gene expression in rifampicin-monoresistant Mycobacterium tuberculosis clinical isolates

    Rifampicin (RIF) resistance is a risk factor for poor outcome in tuberculosis (TB). In Mycobacterium tuberculosis, both target gene mutation and efflux pumps have major roles in the resistance to anti-TB drugs. T...

    Guilian Li, **grui Zhang, Qian Guo, Jianhao Wei, Yi Jiang in The Journal of Antibiotics (2015)

  15. No Access

    Article

    Concentrations, turnover rates and fluxes of polyamines in coastal waters of the South Atlantic Bight

    Polyamines are short-chain aliphatic compounds containing multiple amine groups. They are important components of the cytosol of eukaryotes and are present at mmol L−1 concentrations inside phytoplankton cells, w...

    Qian Liu, **nxin Lu, Bradley B. Tolar, **aozhen Mou, James T. Hollibaugh in Biogeochemistry (2015)

  16. Article

    Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death

    Cytotoxic lymphocytes are key players in the orchestration of immune response and elimination of defective cells. We have previously reported that natural killer (NK) cells enter target tumor cells, leading to...

    Shan Wang, Zhen Guo, Peng **a, Tingting Liu, Jufang Wang, Shan Li in Cell Research (2009)

  17. Article

    Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis

    Alterations in oxidative phosphorylation resulting from mitochondrial dysfunction have long been hypothesized to be involved in tumorigenesis. Mitochondria have recently been shown to play an important role in...

    Jianxin Lu, Lokendra Kumar Sharma, Yidong Bai in Cell Research (2009)

  18. Article

    Open Access

    cTFbase: a database for comparative genomics of transcription factors in cyanobacteria

    Comprehensive identification and classification of the transcription factors (TFs) in a given genome is an important aspect in understanding transcriptional regulatory networks of a specific organism. Cyanobac...

    **yu Wu, Fangqing Zhao, Shengqin Wang, Gang Deng, Junrong Wang, Jie Bai in BMC Genomics (2007)