80 Result(s)

Article

The immunotoxin targeting PRLR increases tamoxifen sensitivity and enhances the efficacy of chemotherapy in breast cancer

Though tamoxifen achieves success in treating estrogen receptor α (ERα)-positive breast cancer, the followed development of tamoxifen resistance is a common challenge in clinic. Signals downstream of prolactin...

Jiawei Zhang, Junjun Liu, Yali Yue, Lei Wang… in Journal of Experimental & Clinical Cancer … (2024)

Article

Temporally Consistent Enhancement of Low-Light Videos via Spatial-Temporal Compatible Learning

Temporal inconsistency is the annoying artifact that has been commonly introduced in low-light video enhancement, but current methods tend to overlook the significance of utilizing both data-centric clues and ...

Lingyu Zhu, Wenhan Yang, Baoliang Chen… in International Journal of Computer Vision (2024)

Article

Red-billed blue magpie optimizer: a novel metaheuristic algorithm for 2D/3D UAV path planning and engineering design problems

Numerical optimization, Unmanned Aerial Vehicle (UAV) path planning, and engineering design problems are fundamental to the development of artificial intelligence. Traditional methods show limitations in deali...

Shengwei Fu, Ke Li, Haisong Huang, Chi Ma, Qingsong Fan… in Artificial Intelligence Review (2024)

Article

Predicting equilibrium distributions for molecular systems with deep learning

Advances in deep learning have greatly improved structure prediction of molecules. However, many macroscopic observations that are important for real-world applications are not functions of a single molecular ...

Shuxin Zheng, Jiyan He, Chang Liu, Yu Shi, Ziheng Lu… in Nature Machine Intelligence (2024)

Article

Linc-NSC affects cell differentiation, apoptosis and proliferation in mouse neural stem cells and embryonic stem cells in vitro and in vivo

Stem cell therapy is a promising therapeutic strategy. In a previous study, we evaluated tumorigenicity by the stereotactic transplantation of neural stem cells (NSCs) and embryonic stem cells (ESCs) from expe...

Lili Guo, Dan Zou, Wenqiao Qiu, Fan Fei, Lihua Chen… in Cellular and Molecular Life Sciences (2024)

Article

ACSL4 accelerates osteosarcoma progression via modulating TGF-β/Smad2 signaling pathway

Osteosarcoma (OS) is a malignant bone sarcoma arising from mesenchymal stem cells. The biological role of Acyl-CoA synthetase long-chain family member 4 (ACSL4), recently identified as an oncogene in numerous ...

**aofeng Li, Qianfen Chen, Duo Zhao, Jianshi Tan… in Molecular and Cellular Biochemistry (2024)

Article

Gorilla optimization algorithm combining sine cosine and cauchy variations and its engineering applications

To address the issues of lacking ability, loss of population diversity, and tendency to fall into the local extreme value in the later stage of optimization searching, resulting in slow convergence and lack of...

Shuxin Wang, Li Cao, Yaodan Chen, Changzu Chen, Yinggao Yue… in Scientific Reports (2024)

Article

Childhood maltreatment and risk of endocrine diseases: an exploration of mediating pathways using sequential mediation analysis

Adverse childhood experiences (ACEs), including childhood maltreatment, have been linked with increased risk of diabetes and obesity during adulthood. A comprehensive assessment on the associations between chi...

Shu Wen, Jianwei Zhu, **n Han, Yuchen Li, Haowen Liu, Huazhen Yang, Can Hou… in BMC Medicine (2024)

Article

Comment on: Association between anemia and depression: results from NHANES 2005–2018 and Mendelian randomization analyses

Tianyu Si, **aolin Ma, Wenwei Zhu, Yongming Zhou in Annals of Hematology (2024)

Article

Correlation between triglyceride glucose index and collateral circulation formation in patients with chronic total occlusion of coronary arteries in different glucose metabolic states

To investigate the correlation between triglyceride glucose index (TyG) and collateral circulation in patients with chronic total occlusion (CTO) of coronary arteries in different glucose metabolic states.

Junwei Zhu, Minghui Niu, Chenxing Wang, Ying Liang, Rong Guo… in Cardiovascular Diabetology (2024)

Article

Immobilization of Thermomyces lanuginosus lipase in a novel polysaccharide-based hydrogel by a two-step crosslinking method and its use in the lauroylation of α-arbutin

The Thermomyces lanuginosus lipase (TLLs) was successfully immobilized within a novel hydrogel matrix through a two-step crosslinking method. TLLs were initially crosslinked through the Schiff base reaction by ox...

Ming Chen, Weina She, **n Zhao, Cheng Chen, Benwei Zhu… in Bioresources and Bioprocessing (2024)

Article

CREaTor: zero-shot cis-regulatory pattern modeling with attention mechanisms

Linking cis-regulatory sequences to target genes has been a long-standing challenge. In this study, we introduce CREaTor, an attention-based deep neural network designed to model cis-regulatory patterns for genom...

Yongge Li, Fusong Ju, Zhiyuan Chen, Yiming Qu, Huanhuan **a, Liang He… in Genome Biology (2023)

Article

Ulvan and Ulva oligosaccharides: a systematic review of structure, preparation, biological activities and applications

Ulva is one of the main green algae causing green tide disasters. Ulvan is the primarily component polysaccharide of the cell wall of Ulva and its complex structure and monosaccharide composition resulted in vari...

Chen Li, Tiancheng Tang, Yuguang Du, Ling Jiang… in Bioresources and Bioprocessing (2023)

Article

Correction: Nectin-4-targeted immunoSPECT/CT imaging and photothermal therapy of triple-negative breast cancer

Fuqiang Shao, Zhidi Pan, Yu Long, Ziyang Zhu, Kun Wang… in Journal of Nanobiotechnology (2023)

Article

scRNA-seq revealed the special TCR β & α V(D)J allelic inclusion rearrangement and the high proportion dual (or more) TCR-expressing cells

Allelic exclusion, one lymphocyte expresses one antigen receptor, is a fundamental mechanism of immunological self-tolerance and highly specific immune responses to pathogens. However, the phenomenon of V(D)J ...

Lanwei Zhu, Qi Peng, Jun Li, Yingjie Wu, Jiayi Wang, Dewei Zhou… in Cell Death & Disease (2023)

Article

The effects of fertility and synchronization variation on seed production in two Chinese fir clonal seed orchards

Variations in fertility and synchronization information is fundamental to seed orchard management. Our objective was to determine clonal variation and stability in strobili production, phenology, synchronizati...

Fang Wang, Shuaiying Zhang, Peng Zhu, Lianghua Chen, Yuanwei Zhu… in Scientific Reports (2023)

Article

Solar Cycle 25 Prediction Using an Optimized Long Short-Term Memory Mode with F10.7

In this paper, an optimized long short-term memory (LSTM) model is proposed to deal with the smoothed monthly ...

Hongbing Zhu, Wenwei Zhu, Mu He in Solar Physics (2022)

Article

Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein–protein interaction inhibitor

In recent years, the flourishing of synthetic methodology studies has provided concise access to numerous molecules with new chemical space. These compounds form a large library with unique scaffolds, but thei...

**g Gu, Rui-Kun Peng, Chun-Ling Guo, Meng Zhang, Jie Yang… in Nature Communications (2022)

Article

Correction: AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11‑dependent inhibition of lipid peroxidation

Rongquan Sun, Zhifei Lin, **angyu Wang… in Journal of Experimental & Clinical Cancer … (2022)

Article

Tumour inhibitory activity on pancreatic cancer by bispecific nanobody targeting PD-L1 and CXCR4

Antibodies and derivative drugs targeting immune checkpoints have been approved for the treatment of several malignancies, but there are fewer responses in patients with pancreatic cancer. Here, we designed a ...

Shuai Hao, Shuyi Xu, Liangzhu Li, Yaxian Li, Meiqi Zhao, Junsheng Chen… in BMC Cancer (2022)