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Article
Open AccessRNA modifications in the progression of liver diseases: from fatty liver to cancer
Non-alcoholic fatty liver disease (NAFLD) has emerged as a prominent global health concern associated with high risk of metabolic syndrome, and has impacted a substantial segment of the population. The disease...
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Article
GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation
Subcellular machinery of NLRP3 is essential for inflammasome assembly and activation. However, the stepwise process and mechanistic basis of NLRP3 engagement with organelles remain unclear. Herein, we demonstr...
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Article
Open AccessThe fermented soy beverage Q-CAN® plus induces beneficial changes in the oral and intestinal microbiome
Soy products are associated with many beneficial health consequences, but their effects on the human intestinal microbiome are poorly characterized.
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Article
Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1α pathway
Inflammasome pathways are important in chronic diseases; however, it is not known how the signalling is sustained after initiation. Inflammasome activation is dependent on stimuli such as lipopolysaccharide (L...
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Article
Open AccessTranscription factor IRF8 directs a silencing programme for TH17 cell differentiation
TH17 cells are recognized as a unique subset of T helper cells that have critical roles in the pathogenesis of autoimmunity and tissue inflammation. Although RORγt is necessary for the generation of TH17 cells, t...
