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  1. No Access

    Article

    The endogenous cannabinoid system controls extinction of aversive memories

    Acquisition and storage of aversive memories is one of the basic principles of central nervous systems throughout the animal kingdom1. In the absence of reinforcement, the resulting behavioural response will grad...

    Giovanni Marsicano, Carsten T. Wotjak, Shahnaz C. Azad, Tiziana Bisogno… in Nature (2002)

  2. No Access

    Article

    SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties

    Mutations in SHANK3 and large duplications of the region spanning SHANK3 both cause a spectrum of neuropsychiatric disorders, indicating that proper SHANK3 dosage is critical for normal brain function. However, S...

    Kihoon Han, J. Lloyd Holder Jr, Christian P. Schaaf, Hui Lu, Hongmei Chen… in Nature (2013)

  3. No Access

    Article

    Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice

    Deep brain stimulation (DBS) of the fimbria–fornix—a region that provides input to the hippocampus—is shown to restore hippocampus-dependent memory and hippocampal long-term potentiation and neurogenesis in a ...

    Shuang Hao, Bin Tang, Zhenyu Wu, Kerstin Ure, Yaling Sun, Huifang Tao, Yan Gao… in Nature (2015)

  4. No Access

    Article

    Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides

    Genetic correction of MeCP2 levels largely reversed the behavioural, molecular and physiological deficits associated with MECP2 duplication syndrome in a transgenic mouse model; similarly, reduction of MeCP2 leve...

    Yehezkel Sztainberg, Hong-mei Chen, John W. Swann, Shuang Hao, Bin Tang… in Nature (2015)

  5. Article

    Open Access

    A ferroptosis-associated gene signature for the prediction of prognosis and therapeutic response in luminal-type breast carcinoma

    Ferroptosis is a new form of regulated cell death (RCD), and its emergence has provided a new approach to the progression and drug resistance of breast cancer (BRCA). However, there is still a great gap in the...

    Yang Peng, Haochen Yu, Yingzi Zhang, Fanli Qu, Zhenrong Tang, Chi Qu… in Scientific Reports (2021)

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  6. Article

    Open Access

    A mitochondrial function-related LncRNA signature predicts prognosis and immune microenvironment for breast cancer

    Mitochondrial function, as the core of the cell's energy metabolism, is firmly connected to cancer metabolism and growth. However, the involvement of long noncoding RNAs (lncRNAs) related to mitochondrial func...

    Yuan Wang, Shun Gao, Yingkun Xu, Zhenrong Tang, Shengchun Liu in Scientific Reports (2023)

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  7. No Access

    Article

    A new avialan theropod from an emerging Jurassic terrestrial fauna

    Birds are descended from non-avialan theropod dinosaurs of the Late Jurassic period, but the earliest phase of this evolutionary process remains unclear owing to the exceedingly sparse and spatio-temporally re...

    Liming Xu, Min Wang, Runsheng Chen, Li** Dong, Min Lin, **ng Xu, Jianrong Tang… in Nature (2023)