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Article
Open AccessIntermediate soil acidification induces highest nitrous oxide emissions
Global potent greenhouse gas nitrous oxide (N2O) emissions from soil are accelerating, with increases in the proportion of reactive nitrogen emitted as N2O, i.e., N2O emission factor (EF). Yet, the primary contro...
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Article
Open AccessEstablish a novel tumor budding-related signature to predict prognosis and guide clinical therapy in colorectal cancer
Tumor budding is a long-established independent adverse prognostic marker for colorectal cancer (CRC), yet assessment of tumor budding was not reproducible. Therefore, development of precise diagnostic approac...
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Article
Open AccessAnesthesia management experience for pediatric day-case PDA ligation under thoracoscopy assisted by a robot: a retrospective study
To summarize the anesthesia management experience for pediatric day-case patent ductus arteriosus (PDA) ligation under robot-assisted thoracoscopy and explore the key points of anesthesia management for this p...
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Article
Open AccessExtrachromosomal circular DNA in colorectal cancer: biogenesis, function and potential as therapeutic target
Extrachromosomal circular DNA (ecDNA) has gained renewed interest since its discovery more than half a century ago, emerging as critical driver of tumor evolution. ecDNA is highly prevalent in many types of ca...
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Article
Preparation, Characterization, and In Vitro Pharmacodynamics and Pharmacokinetics Evaluation of PEGylated Urolithin A Liposomes
Urolithin A (Uro-A), a metabolite of ellagitannins in mammals’ intestinal tract, displays broad biological properties in preclinical models, including anti-oxidant, anti-inflammatory, and anti-tumor effects. H...
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Article
An improved real-time endovascular guidewire position simulation using shortest path algorithm
In this study, we propose a new graph-theoretical method to simulate guidewire paths inside the carotid artery. The minimum energy guidewire path can be obtained by applying the shortest path algorithm, such a...
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Article
Open AccessCirculating memory T follicular helper subsets, Tfh2 and Tfh17, participate in the pathogenesis of Guillain-Barré syndrome
Circulating memory T follicular helper subsets, Tfh2 and Tfh17 are found to be aberrantly regulated in many autoimmune diseases. However, their roles in the pathogenesis of GBS are still unclear. This study ex...
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Article
Increased Numbers of Circulating ICOS+ Follicular Helper T and CD38+ Plasma Cells in Patients with Newly Diagnosed Primary Biliary Cirrhosis
Aberrant activation of follicular helper T (TFH) and B cells is associated with the development of autoimmune diseases. However, little is known about the potential role of these cells in the development of pr...
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Article
Open AccessIncreased numbers of CD5+CD19+CD1dhighIL-10+ Bregs, CD4+Foxp3+ Tregs, CD4+CXCR5+Foxp3+ follicular regulatory T (TFR) cells in CHB or CHC patients
IL-10+ regulatory B (Bregs), CD4+Foxp3+ regulatory T (Tregs), and CD4+CXCR5+Foxp3+ follicular regulatory T (TFR) cells regulate the progression of infection disease. This study aimed at examining how those cells ...
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Chapter and Conference Paper
Study of Collaborative Design Based on Fuzzy Theory
Under the Ontology-based collaborative design framework constructed by OWL and SWRL, in order to further extend the expression and reasoning abilities of domain knowledge description and to achieve the reasoni...
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Chapter and Conference Paper
An Ontology-Based Collaborative Design System
A collaborative design system architecture based on ontology is proposed. In the architecture, OWL is used to construct global shared ontology and local ontology; both of them are machine-interpretable. The fo...
