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Article
Computational study on the binding mechanism of allosteric drug TNO155 inhibiting SHP2E76A
E76A mutations of SHP2 have been reported to associate with genetic developmental diseases and cancers, and TNO155 is one of the effective inhibitors targeted to the allosteric site 1, which has already entered t...
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Article
Open AccessCHOP-mediated Gasdermin E expression promotes pyroptosis, inflammation, and mitochondrial damage in renal ischemia-reperfusion injury
In clinical practice, renal ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI), often leading to acute renal failure or end-stage renal disease (ESRD). The current understanding o...
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Article
Open AccessMechanism exploration and biomarker identification of glycemic deterioration in patients with diseases of the exocrine pancreas
The damage to the endocrine pancreas among patients with diseases of the exocrine pancreas (DP) leads to reduced glycemic deterioration, ultimately resulting in diabetes of the exocrine pancreas (DEP). The pre...
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Article
Analysis of piezoelectric semiconductor fibers under gradient temperature changes
Piezoelectric semiconductors (PSs) possess both semiconducting properties and piezoelectric coupling effects, making them optimal building blocks for semiconductor devices. PS fiber-like structures have wide a...
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Article
Open AccessA Novel Platinum Resistance-Related Immune Gene Signature for Overall Survival Prediction in Patients with Ovarian Cancer
Ovarian cancer (OV) is a highly heterogeneous gynecological tumor that makes the prognostic prediction challenging. Resistance to platinum-based chemotherapy is associated with a poor prognosis in OV. There se...
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Article
Driver fatigue detection and human-machine cooperative decision-making for road scenarios
Driver fatigue detection and human-machine cooperative decision-making are key issues in intelligent transportation systems. The proposed method consists of two main stages.In the first stage, we propose an im...
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Article
Open AccessSingle-cell and transcriptomic analyses reveal the influence of diabetes on ovarian cancer
There has been a significant surge in the global prevalence of diabetes mellitus (DM), which increases the susceptibility of individuals to ovarian cancer (OC). However, the relationship between DM and OC rema...
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Article
Open AccessInvestigation of the response of Platycodongrandiflorus (Jacq.) A. DC to salt stress using combined transcriptomics and metabolomics
Platycodon grandiflorus (Jacq.) A. DC is a famous traditional Chinese medicine in China and an authentic medicine in Inner Mongolia. It has been traditionally used as an expectorant in cough and also has anti-inf...
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Article
Least absolute deviation estimation for AR(1) processes with roots close to unity
We establish the asymptotic theory of least absolute deviation estimators for AR(1) processes with autoregressive parameter satisfying $$n(\rh...
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Article
Open AccessAntimicrobial peptides act on the rumen microbiome and metabolome affecting the performance of castrated bulls
Many countries have already banned the use of antibiotics in animal husbandry, making it extremely difficult to maintain animal health in livestock breeding. In the livestock industry, there is an urgent need ...
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Article
ATP1A3-related phenotypes in Chinese children: AHC, CAPOS, and RECA
The aim of this research is to study the phenotype, genotype, treatment strategies, and short-term prognosis of Chinese children with ATP1A3 (Na+/K+-ATPase alpha 3 gene)-related disorders in Southwest China. Pati...
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Article
Open AccessGene expressions between obligate bamboo-eating pandas and non-herbivorous mammals reveal converged specialized bamboo diet adaptation
It is inevitable to change the function or expression of genes during the environmental adaption of species. Both the giant panda (Ailuropoda melanoleuca) and red panda (Ailurus fulgens) belong to Carnivora and h...
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Chapter and Conference Paper
Pacesetter Learning for Large Scale Cooperative Multi-Agent Reinforcement Learning
In complex multi-agent reinforcement learning environments, such as Starcraft II, most existing algorithms struggle to scale up to large-scale collaboration tasks. This is partly because learning to precisely ...
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Article
Open AccessFulminant anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluR1 antibodies encephalitis in a Chinese boy: a case report
Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) encephalitis is a rare autoimmune synaptic encephalitis associated with autoantibodies that cause a selective decrease in surface expr...
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Article
Open AccessMainstream encoding–decoding methods of DNA data storage
DNA storage is a new digital data storage technology based on specific encoding and decoding methods between 0 and 1 binary codes of digital data and A-T-C-G quaternary codes of DNAs, which and is expected to ...
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Article
Element tests on the hydraulic/mechanical behaviour of unsaturated decomposed granite soil under various conditions
Masado is a completely decomposed granite soil widely distributed in western Japan. One of the major causes of the failure of a slope, either made of natural Masado (cut slope) or manmade Masado (reclaimed slo...
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Article
Open AccessImpact of childbirth policy changes on obstetric workload over a 13-year period in a regional referral center in China – implications on service provision planning
We aimed to appraise the impact of the changing national childbirth policy since 2002, currently allowing two children per family, on obstetric workload in a regional referral center in China.
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Article
Open AccessChronic maternal hepatitis B virus infection and pregnancy outcome- a single center study in Kunming, China
Chinese population has a high prevalence of chronic hepatitis B virus (HBV) infection, the impact of which on pregnancy outcome remains controversial. A single-center retrospective cohort study was performed i...
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Article
Open AccessChildhood ischaemic stroke in the basal ganglia can lead to fine motor and anxiety disorders: a retrospective analysis and follow-up of 109 cases
Stroke in children easily causes long-term dysfunction. Whether the prognoses of motor and anxiety disorders are related to the affected stroke area has not been reported.
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Article
Open AccessCharacteristics and outcomes of children with dissociative (conversion) disorders in western China: a retrospective study
Dissociative (conversion) disorder in children is a complex biopsychosocial disorder with high rates of medical and psychiatric comorbidities. We sought to identify the characteristics and outcomes of children...
