21 Result(s)

Article

Achyranthes bidentata extract exerts osteoprotective effects on steroid-induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling

Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) presents great challenges due to the various effects of steroids on multi-system pathways involved into osteoblast differentiation, oste...

Yini Jiang, Yanqiong Zhang, Weiheng Chen, Chunfang Liu… in Journal of Translational Medicine (2014)

Article

Higher heat shock factor 1 expression in tumor stroma predicts poor prognosis in esophageal squamous cell carcinoma patients

Heat shock factor 1 (HSF1) is a powerful, multifaceted modifier of carcinogenesis. However, the clinical significance and biologic function of HSF1 in esophageal squamous cell carcinoma (ESCC) remain unknown.

Yuehua Liao, Ying Xue, Lin Zhang, **nwei Feng… in Journal of Translational Medicine (2015)

Article

Higher IGFBP-1 to IGF-1 serum ratio predicts unfavourable survival in patients with nasopharyngeal carcinoma

The insulin-like growth factor (IGF) system plays an important role in the development and progression of cancer. However, little is known about the expression of the IGF system components and their clinicopat...

**nwei Feng, Jianhua Lin, Shan **ng, Wanli Liu, Ge Zhang in BMC Cancer (2017)

Article

Establishment and validation of a predictive nomogram model for non-small cell lung cancer patients with chronic hepatitis B viral infection

This study aimed to establish an effective predictive nomogram for non-small cell lung cancer (NSCLC) patients with chronic hepatitis B viral (HBV) infection.

Shulin Chen, Yanzhen Lai, Zhengqiang He, Jianpei Li… in Journal of Translational Medicine (2018)

Article

Complete pathological response following neoadjuvant FOLFOX chemotherapy in BRCA2-mutant locally advanced rectal cancer: a case report

Patients with locally advanced rectal cancer (LARC) achieving a pathological complete response (pCR) to neoadjuvant treatment usually have a good prognosis, but only accounted for less than 20%.

Zhenyu Lin, Junli Liu, Li Peng, Dejun Zhang, Ming **, **g Wang, Jun Xue… in BMC Cancer (2018)

Article

Efficacy and safety of tetramethylpyrazine phosphate on pulmonary hypertension: study protocol for a randomized controlled study

Tetramethylpyrazine (TMP), an active ingredient in the traditional Chinese herbal medicine Rhizoma Chuanxiong, has been used clinically for the prevention and treatment of cardiovascular disease. The benefits ...

Yuqin Chen, Wenjun He, Hai** Ouyang, Chunli Liu, Cheng Hong, Tao Wang, Kai Yang… in Trials (2019)

Article

Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling

The B7-family inducible costimulator (ICOS) activates phosphoinositide-3 kinase (PI3K) and augments calcium mobilization triggered by the T-cell receptor (TCR). We surprisingly found that the entire cytoplasmi...

Zurong Wan, **ngxing Shao, **ngyu Ji, Lihui Dong… in Cellular & Molecular Immunology (2020)

Article

Comparison of the efficacy and safety of tacrolimus monotherapy and cyclophosphamide combined with glucocorticoid in the treatment of adult primary membranous nephropathy: protocol of a multicenter, randomized, controlled, open study

Idiopathic membranous nephropathy (IMN) remains the leading cause of adult nephrotic syndrome. Immunosuppressive therapy with cyclophosphamide (CTX) is often successful in reducing proteinuria, but its use is ...

Shasha Chen, Song Ren, Amanda Y. Wang, Hieu Tran, Zheng Li, **aoyun Cheng… in Trials (2020)

Article

Correction to: Efficacy and safety of tetramethylpyrazine phosphate on pulmonary hypertension: study protocol for a randomized controlled study

After publication of our article [1] the authors have notified us of two typos in the Trial status.

Yuqin Chen, Wenjun He, Hai** Ouyang, Chunli Liu, Cheng Hong, Tao Wang, Kai Yang… in Trials (2020)

Article

The telomerase gene polymorphisms, but not telomere length, increase susceptibility to primary glomerulonephritis/end stage renal diseases in females

Primary glomerulonephritis (GN) is the leading cause of chronic kidney disease (CKD) and frequently progresses into end stage renal diseases (ESRDs). Shorter leukocyte telomere length (LTL) has been implicated...

Qing Sun, Junli Liu, Guanghui Cheng, Mingkai Dai… in Journal of Translational Medicine (2020)

Article

The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity

T follicular helper (Tfh) cells are crucial for regulating autoimmune inflammation and protective immunity against viral infection. However, the molecular mechanism controlling Tfh cell differentiation is poor...

**nfang Huang, Shumeng Hao, Junli Liu, Yuanyuan Huang… in Cellular & Molecular Immunology (2021)

Article

Correction to: Achyranthes bidentata extract exerts osteoprotective effects on steroid-induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling

An amendment to this paper has been published and can be accessed via the original article.

Yini Jiang, Yanqiong Zhang, Weiheng Chen, Chunfang Liu… in Journal of Translational Medicine (2021)

Article

Effects of Jianpi Lishi Jiedu granules on colorectal adenoma patients after endoscopic treatment: study protocol for a randomized, double-blinded, placebo-controlled clinical trial

Colorectal adenomas (CRAs) are precancerous lesions of the large intestine presenting as colorectal polyps. At present, the conventional treatment methods for CRA mainly include high-frequency electrocoagulati...

Hao Wu, Yuzhen Huang, Lu Yang, Kunhan Su, Shuo Tian, **n Chen, Siyu Li, Wanli Liu in Trials (2022)

Article

A graph-based genome and pan-genome variation of the model plant Setaria

Setaria italica (foxtail millet), a founder crop of East Asian agriculture, is a model plant for C4 photosynthesis and develo** approaches to adaptive breeding across multiple climates. Here we established the

Qiang He, Sha Tang, Hui Zhi, **feng Chen, Jun Zhang, Hongkai Liang… in Nature Genetics (2023)

Article

Volume-targeted ventilation vs pressure-controlled ventilation for very low birthweight infants: a protocol of a randomized controlled trial

Mechanical ventilation (MV) is essential in the management of critically ill neonates, especially preterm infants. However, inappropriate or prolonged use of invasive MV may result in ventilator-associated lun...

Jun Tang, Lingyue Gong, Tao **ong, Chao Chen, Ke Tian, Aoyu Wang, Yi Huang… in Trials (2023)

Article

High-flow nasal cannula (HFNC) vs continuous positive airway pressure (CPAP) vs nasal intermittent positive pressure ventilation as primary respiratory support in infants of ≥ 32 weeks gestational age (GA): study protocol for a three-arm multi-center randomized controlled trial

Health problems in neonates with gestational age (GA) ≥ 32 weeks remain a major medical concern. Respiratory distress (RD) is one of the common reasons for admission of neonates with GA ≥ 32 weeks. Noninvasive...

Rong Zhou, Tao **ong, Jun Tang, Yi Huang, Wenli Liu, Jun Zhu, Chao Chen… in Trials (2023)

Article

Contrast media extravasation injury: a prospective observational cohort study

To identify the risk factors for moderate and severe contrast media extravasation and provide effective guidance to reduce the degree of extravasation injuries.

Wanli Liu, **hu Wang, Hui Zhu, Hui Tang… in European Journal of Medical Research (2023)

Article

Author Correction: KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape

Ye Li, Rafet Basar, Guohui Wang, Enli Liu, Judy S. Moyes, Li Li… in Nature Medicine (2024)

Article

Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19⁺ B cell tumors: a phase 1/2 trial

There is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord blood-derived natural killer (NK) c...

David Marin, Ye Li, Rafet Basar, Hind Rafei, May Daher, **zhuang Dou… in Nature Medicine (2024)

Article

Identification of BACH1-IT2-miR-4786-Siglec-15 immune suppressive axis in bladder cancer

The sialic acid binding Ig like lectin 15 (Siglec-15) was previously identified as tumor immune suppressor gene in some human cancers with elusive molecular mechanism to be elucidated. The continuous focus on ...

**ngzhi Li, Ziji Liang, Jiexin Pan, Meng Zhang, **li Liu, Rong Hu… in BMC Cancer (2024)