15 Result(s)

Article

The growth of B cell receptor microcluster is a universal response of B cells encountering antigens with different motion features

B lymphocyte cell senses and acquires foreign antigens through clonal distributed B cell receptors (BCRs) expressed on the surface of plasma membrane. The presentation formats of antigens are quite diverse. Ba...

Zhengpeng Wan, Wanli Liu in Protein & Cell (2012)

Article

Erratum: Structural biology: HDAC6 finally crystal clear

Nat. Chem. Biol. 12, 660–661 (2016); published online 18 August 2016; corrected after print 26 August 2016. In the article originally published, the author omitted a reference describing the discovery of HDAC6...

Yanli Liu, Li Li, **rong Min in Nature Chemical Biology (2016)

Article

Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway

Tanshinones belong to a group of lipophilic constituents of Salvia miltiorrhiza Bunge (Danshen), which is widely used in traditional Chinese medicine. A deluge of studies demonstrated that tanshinones exert anti-...

Hongwei Gao, **n Liu, Wen Sun, Naixin Kang, Yanli Liu, Shilin Yang… in Cell Death & Disease (2017)

Article

Transmembrane domain dependent inhibitory function of FcγRIIB

FcγRIIB, the only inhibitory IgG Fc receptor, functions to suppress the hyper-activation of immune cells. Numerous studies have illustrated its inhibitory function through the ITIM motif in the cytoplasmic tai...

Junyi Wang, Zongyu Li, Liling Xu, Hengwen Yang, Wanli Liu in Protein & Cell (2018)

Article

Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1

Jacob I Stuckey, Bradley M Dickson, Nancy Cheng, Yanli Liu… in Nature Chemical Biology (2019)

Article

SNRPB promotes the tumorigenic potential of NSCLC in part by regulating RAB26

SNRPB is a core component of spliceosome and plays a major role in regulating alternative splicing of the pre-mRNA. However, little is known about its role in cancer to date. In this study, we observe that SNR...

Nianli Liu, Zhiyuan Wu, Aoxing Chen, Yuqi Wang, Dafei Cai… in Cell Death & Disease (2019)

Article

CPEB3 deficiency in mice affect ovarian follicle development and causes premature ovarian insufficiency

Premature ovarian insufficiency (POI) is a heterogeneous and multifactorial disorder. In recent years, there has been an increasing interest in research on the pathogenesis and treatment of POI, owing to the i...

Fang E., He Zhang, Wanli Yin, Chongyang Wang, Yuanli Liu, Yanze Li… in Cell Death & Disease (2021)

Article

Sustainable Production and Activity Determination of Serum-Free Conditioned Medium from Menstrual Blood-Derived Endometrial Stem Cells

Mesenchymal stem cells (MSCs) have exhibited great potential as a regenerative medicine, and MSC-derived paracrine effects, mainly including the secretion of various bioactive factors, play critical roles in M...

Lingrui Shang, Ruiyun Zhang, Jiaxing Yan… in Applied Biochemistry and Biotechnology (2023)

Article

ADAMTS9-AS1 inhibits tumor growth and drug resistance in clear cell renal cell carcinoma via recruiting HuR to enhance ADAMTS9 mRNA stability

The lack of efficacious treatments for clear cell renal cell carcinoma (ccRCC) has led to a poor 5-year survival rate. Here, we found that the expression of ADAM metallopeptidase with thrombospondin type 1 mot...

Enyang Zhao, Bo Geng, Ran Tao, Bosen You, Yunli Liu, Wenbin Hou… in Cancer Nanotechnology (2023)

Article

Chemotherapy impairs ovarian function through excessive ROS-induced ferroptosis

Chemotherapy was conventionally applied to kill cancer cells, but regrettably, they also induce damage to normal cells with high-proliferative capacity resulting in cardiotoxicity, nephrotoxicity, peripheral n...

Shenghui Zhang, Qin Liu, Mengyuan Chang, Ying Pan… in Cell Death & Disease (2023)

Article

Circular RNA circRANGAP1/miR-512-5p/SOD2 Axis Regulates Cell Proliferation and Migration in Non-small Cell Lung Cancer (NSCLC)

Non-small cell lung cancer (NSCLC) is the most prevalent histology type of lung cancer worldwide, accounting for 18% of total cancer-related deaths estimated by GLOBOCAN in 2020. CircRNAs have emerged as poten...

Chunhua Zhao, Zhongqi Zhang, Zhengzuo Wang, **nLi Liu in Molecular Biotechnology (2023)

Article

Inhibition of EHMT1/2 rescues synaptic damage and motor impairment in a PD mouse model

Epigenetic dysregulation that leads to alterations in gene expression and is suggested to be one of the key pathophysiological factors of Parkinson’s disease (PD). Here, we found that α-synuclein preformed fib...

Zhixiong Zhang, Rui Wang, Hui Zhou, Dan Wu… in Cellular and Molecular Life Sciences (2024)

Article

Macrophage-derived ectosomal miR-350-3p promotes osteoarthritis progression through downregulating chondrocyte H3K36 methyltransferase NSD1

Mechanical overloading can promote cartilage senescence and osteoarthritis (OA) development, but its impact on synovial macrophages and the interaction between macrophages and chondrocytes remain unknown. Here...

Rengui Lin, Jianbin Yin, Jialuo Huang, Li** Zou, Liangliang Liu… in Cell Death Discovery (2024)

Article

The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif

PTENα/β, two variants of PTEN, play a key role in promoting tumor growth by interacting with WDR5 through their N-terminal extensions (NTEs). This interaction facilitates the recruitment of the SET1/MLL methyl...

**aolei Huang, Cheng Zhang, **nci Shang, Yichang Chen, Qin **ao… in Cell Death & Disease (2024)

Article

Protective Effect of CXCR7 Against Hypoxia/Reoxygenation Injury in Renal Tubular Epithelial Cells

Acute kidney injury (AKI) is a multifactorial syndrome with complex pathophysiology and prognosis. Ischaemia‒reperfusion injury (IRI) is a major cause of induced AKI. The aim of this study was to investigate t...

** Meng, Chunli Liu, **gchun Li, ** Fang… in Cell Biochemistry and Biophysics (2024)