48 Result(s)
within
**nhai Zhang
Biomedicine
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Article
Preparation, characterization, oral bioavailability, and pharmacodynamic study of eugenol-porous silica solidified powder
Eugenol possesses anti-inflammatory and antioxidant properties, and may serve as a potential therapeutic agent for hepatic fibrosis. However, the development of solid eugenol formulations is challenging due to...
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Article
Correction to: ’Roles of Prokineticin 2 in Subarachnoid Hemorrhage-Induced Early Brain Injury via Regulation of Phenotype Polarization in Astrocytes’
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Article
Multiple-source distribution deep adaptive feature norm network for EEG emotion recognition
Electroencephalogram (EEG) emotion recognition plays an important role in human–computer interaction, and a higher recognition accuracy can improve the user experience. In recent years, domain adaptive methods...
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Article
Open AccessAMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma
Adenosine monophosphate-activated protein kinase (AMPK) is associated with the development of liver hepatocellular carcinoma (LIHC). AMPKα2, an α2 subunit of AMPK, is encoded by PRKAA2, and functions as the catal...
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Article
Instance-representation transfer method based on joint distribution and deep adaptation for EEG emotion recognition
Electroencephalogram (EEG) emotion recognition technology is essential for improving human–computer interaction. However, the practical application of emotion recognition technology is limited due to the varie...
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Article
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats
Background: Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), regulated by AMPK, is an important regulator of mitochondrial fusion. At present, whether the AMPK/PGC-1α signaling pathway regula...
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Article
Open AccessThe clinicopathological characteristics of POLE-mutated/ultramutated endometrial carcinoma and prognostic value of POLE status: a meta-analysis based on 49 articles incorporating 12,120 patients
This study was designed to investigate the frequency and clinicopathological characteristics of POLE-mutated/ultramutated (POLEmut) in endometrial carcinoma (EC) and assess the prognostic values of POLE status.
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Article
Open AccessAttention allocation on mobile app interfaces when human interacts with them
With the popularity of smartphones and the pervasion of mobile apps, people spend more and more time to interact with a diversity of apps on their smartphones, especially for young population. This raises a qu...
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Article
Alda-1, an Activator of ALDH2, Improves Postresuscitation Cardiac and Neurological Outcomes by Inhibiting Pyroptosis in Swine
Aldehyde dehydrogenase 2 (ALDH2) has been proven to protect the heart and brain against regional ischemia/reperfusion injury, in which the protective role is related to the inhibition of pyroptosis. In the pre...
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Article
The role of dorsal root ganglia alpha-7 nicotinic acetylcholine receptor in complete Freund’s adjuvant-induced chronic inflammatory pain
Alpha-7 nicotinic acetylcholine receptor (α7 nAChR) was reported to have a critical role in the regulation of pain sensitivity and neuroinflammation. However, the expression level of α7 nAChR in dorsal root ga...
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Article
Application of expert system and LSTM in extracting index of synaptic plasticity
The indexes of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), can usually be measured by evaluating the slope and/or magnitude of field excitatory postsynaptic pote...
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Application of Insoluble Excipients in Solid Dispersion of Chinese Medicines
In recent years, as the great success of arteannuin in the area of antimalarial treatment and commercial benefit, traditional Chinese medicine (TCM) has received great attention. However, most of the active ph...
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Article
Open AccessProgressive multifocal leukoencephalopathy in an HIV patient was diagnosed by 3 times lumbar punctures and 2 times brain biopsies
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the central nervous system caused by JC virus (JCV) and is difficult to diagnose. We report on a male HIV-positive patient wi...
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Article
EEG-based emotion recognition using 4D convolutional recurrent neural network
In this paper, we present a novel method, called four-dimensional convolutional recurrent neural network, which integrating frequency, spatial and temporal information of multichannel EEG signals explicitly to...
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Article
Roles of Prokineticin 2 in Subarachnoid Hemorrhage-Induced Early Brain Injury via Regulation of Phenotype Polarization in Astrocytes
Previous studies have postulated that neuroinflammation can induce two different types of reactive astrocytes, A1 and A2. A1 astrocytes may be harmful, whereas A2 astrocytes may be protective. Specifically, pr...
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Article
Open AccessTMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion
As the main organelles for the clearance of damaged proteins and damaged organelles, the function of lysosomes is crucial for maintaining the intracellular homeostasis of long-lived neurons. A stable acidic en...
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Article
Open AccessCX3CL1/CX3CR1 axis attenuates early brain injury via promoting the delivery of exosomal microRNA-124 from neuron to microglia after subarachnoid hemorrhage
Microglial activation-mediated neuroinflammation is a major contributor to early brain injury (EBI) after subarachnoid hemorrhage (SAH). MicroRNA-124 (miR-124) is the most abundant miRNAs in the central nervou...
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Article
The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity
Cancer cells subvert immune surveillance through inhibition of T cell effector function. Elucidation of the mechanism of T cell dysfunction is therefore central to cancer immunotherapy. Here, we report that du...
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Article
Preparation and Characterization of Honokiol Nanosuspensions and Preliminary Evaluation of Anti-Inflammatory Effect
The study mainly aimed to improve the solubility of honokiol (HK) by preparing honokiol nanosuspensions (HNS). In this study, HNS were obtained using Kolliphor®P407 (P407) as a stabilizer through melting metho...
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Article
Open AccessA panel of Transcription factors identified by data mining can predict the prognosis of head and neck squamous cell carcinoma
Transcription factors (TFs) are responsible for the regulation of various activities related to cancer like cell proliferation, invasion, and migration. It is thought that, the measurement of TFs levels could ...
