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Open AccessOBMI: oversampling borderline minority instances by a two-stage Tomek link-finding procedure for class imbalance problem
Mitigating the impact of class imbalance datasets on classifiers poses a challenge to the machine learning community. Conventional classifiers do not perform well as they are habitually biased toward the major...
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Article
Open AccessAPOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia
Several genetic risk factors for Alzheimer’s disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells1. However, the relationship between lipid metabo...
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Article
Open AccessAnalysis of global gene expression using RNA-sequencing reveals novel mechanism of Yanghe **chuan decoction in the treatment of asthma
Yanghe **chuan decoction (YPD) has been used for asthma treatment for many years in China. We sought to understand the mechanism of YPD, and find more potential targets for YPD-based treatment of asthma.
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Article
Open AccessHS-Gen: a hypersphere-constrained generation mechanism to improve synthetic minority oversampling for imbalanced classification
Mitigating the impact of class-imbalance data on classifiers is a challenging task in machine learning. SMOTE is a well-known method to tackle this task by modifying class distribution and generating synthetic...
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Article
Open AccessIdentification and characterization of circRNAs in peri-implantation endometrium between Yorkshire and Erhualian pigs
One of the most critical periods for the loss of pig embryos is the 12th day of gestation when implantation begins. Recent studies have shown that non-coding RNAs (ncRNAs) play important regulatory roles durin...
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Open AccessMulti-step biosynthesis of the biodegradable polyester monomer 2-pyrone-4,6-dicarboxylic acid from glucose
2-Pyrone-4,6-dicarboxylic acid (PDC), a chemically stable pseudoaromatic dicarboxylic acid, represents a promising building block for the manufacture of biodegradable polyesters. Microbial production of PDC ha...
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Open AccessDeciphering the pharmacological mechanisms of Fraxini Cortex for ulcerative colitis treatment based on network pharmacology and in vivo studies
Ulcerative colitis (UC) is a common type of inflammatory bowel disease. Due to the elusive pathogenesis, safe and effective treatment strategies are still lacking. Fraxini Cortex (FC) has been widely used as a me...
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Article
Open AccessHigh dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer
Cancer cells require a supply of amino acids, particularly essential amino acids such as branched-chain amino acids (BCAAs, i.e., valine, leucine, and isoleucine), to meet the increased nutrient demands of mal...
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Open AccessIdentification of novel targets and pathways to distinguish suicide dependent or independent on depression diagnosis
In recent years, postmortem brain studies have revealed that some molecular, cellular, and circuit changes associated with suicide, have an independent or additive effect on depression. The aim of the present ...
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Article
Open AccessLife expectancy and healthy life expectancy of patients with advanced schistosomiasis in Hunan Province, China
Few studies have investigated the change in life expectancy (LE) and the healthy lifespan among patients with advanced schistosomiasis. This study was to evaluate the LE and healthy life expectancy (HLE) for p...
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Open AccessLeft ventricular non-compaction cardiomyopathy associated with the PRKAG2 mutation
Left ventricular non-compaction cardiomyopathy (LVNC) is one of the most common inherited cardiovascular diseases. The genetic backgrounds of most LVNC patients are not fully understood. We collected clinical ...
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Article
Open AccessYolov3-Pruning(transfer): real-time object detection algorithm based on transfer learning
In recent years, object detection algorithms have achieved great success in the field of machine vision. To pursue the detection accuracy of the model, the scale of the network is constantly increasing, which ...
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Open AccessAn integrated method for optimized identification of effective natural inhibitors against SARS-CoV-2 3CLpro
The current severe situation of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has not been reversed and posed great threats to global health. Theref...
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Article
Open AccessRNA-Seq based transcriptome analysis in oral lichen planus
Oral lichen planus (OLP) is a T cell-mediated autoimmune disease recognized as an oral potential malignant disorder (OPMD) with the precise mechanism unknown. This study focused on the transcriptional profiles...
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Article
Open AccessCerebral cysticercosis mimicking subarachnoid hemorrhage: a case report
Dense exudate during the calcification of cerebral cysticercosis in basal subarachnoid space was easy to be misdiagnosed as subarachnoid hemorrhage (SAH); clinical evaluation and MRI can help differentiate SAH...
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Open AccessSystems pharmacology and transcriptomics reveal the mechanisms of Sanhuang decoction enema in the treatment of ulcerative colitis with additional Candida albicans infection
Ulcerative colitis (UC) is an important inflammatory phenotype in bowel disease (IBD), which is caused by multiple potential factors, including fungal dysbiosis. Candida albicans (C. albicans) was confirmed to be...
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Article
Open AccessPredictive value of pentraxin-3 on disease severity and mortality risk in patients with hemorrhagic fever with renal syndrome
Hemorrhagic fever with renal syndrome (HFRS) caused by Hantaan virus is characterized by systemic immunopathological injury. Pentraxin-3 is an acute-phase reactant involved in the processes of inflammation and...
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Article
Open AccessSystematic elucidation of the pharmacological mechanisms of Rhynchophylline for treating epilepsy via network pharmacology
Epilepsy, one of the most common neurological disorders, affects over 70 million people worldwide. Rhynchophylline displays a wide variety of pharmacologic actives. However, the pharmacologic effects of rhynch...
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Erratum to: A Novel Nonlinear Link Element for Direct Second-Order Analysis of Trusses Assembled by Weak Shear Stiffness Members
This erratum is published to notify a correction in the title of the article. See the corrected version below:
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Correction to: Combined application of electronic nose analysis and back‑propagation neural network and random forest models for assessing yogurt flavor acceptability
The original version of the article unfortunately contained an error in one of the affiliations of the first author, Dr. Huaixiang Tian. The institution name was incorrectly published as ‘State Key Laboratory ...
