24 Result(s)
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**ngzhong Wang
Biotechnology
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Article
Suppressing the virulence factors of Candida auris with baicalein through multifaceted mechanisms
Candida auris, a rapidly spreading multi-drug‐resistant fungus, is causing lethal infections under certain conditions globally. Baicalin (BE), an active ingredient extracted from the dried root of Scutellaria bai...
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Article
Production of bilirubin via whole-cell transformation utilizing recombinant Corynebacterium glutamicum expressing a β-glucuronidase from Staphylococcus sp. RLH1
Bilirubin, a key active ingredient of bezoars with extensive clinical applications in China, is produced through a chemical process. However, this method suffers from inefficiency and adverse environmental imp...
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Article
Siderophore-synthesizing NRPS reprogram lipid metabolic profiles for phenotype and function changes of Arthrobotrys oligospora
The objective of this paper is to explore the function of the AOL-s00215g415 (Aog415) gene, which encodes for the synthesis of siderophore in the nematode trap** fungal model strain A. oligospora, in order to u...
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Article
Open AccessMulti-step biosynthesis of the biodegradable polyester monomer 2-pyrone-4,6-dicarboxylic acid from glucose
2-Pyrone-4,6-dicarboxylic acid (PDC), a chemically stable pseudoaromatic dicarboxylic acid, represents a promising building block for the manufacture of biodegradable polyesters. Microbial production of PDC ha...
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Article
The role of WSC domain-containing protein encoding gene AOL_s00043g401 in the growth and nematode trap** of Arthrobotrys oligospora
Arthrobotrys oligospora is a model nematode-trap** fungus that has been extensively investigated to understand the interactions between fungi and nematodes. Nematode capture by A. oligospora is a complex proces...
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Article
Site-directed mutagenesis of coenzyme-independent carotenoid oxygenase CSO2 to enhance the enzymatic synthesis of vanillin
Vanillin is a popular flavoring compound and an important food additive. Owing to the consumer preference for inexpensive natural aroma flavors, vanillin production through a biotechnological pathway has becom...
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Article
Open AccessRepeated fed-batch strategy and metabolomic analysis to achieve high docosahexaenoic acid productivity in Crypthecodinium cohnii
Docosahexaenoic acid (DHA) is essential for human diet. However, high production cost of DHA using C. cohnii makes it currently less competitive commercially, which is mainly caused by low DHA productivity. In re...
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Article
Open AccessA novel fungal beta-propeller phytase from nematophagous Arthrobotrys oligospora: characterization and potential application in phosphorus and mineral release for feed processing
Phytases are widely utilized in feed industry to increase the utilization of phosphorus, minerals, and amino acids for improvement of animal and human nutrition. At present, all known β-propeller phytases (BPP...
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Article
Open AccessUse of fusion transcription factors to reprogram cellulase transcription and enable efficient cellulase production in Trichoderma reesei
Trichoderma reesei is widely used for cellulase production and accepted as an example for cellulase research. Cre1-mediated carbon catabolite repression (CCR) can significantly inhibit the transcription of cellul...
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Article
Impacts of environmental factors on microbial diversity, distribution patterns and syntrophic correlation in anaerobic processes
Anaerobic processes are widely used for treating high-strength organic wastewater. Understanding the ecological patterns of the microorganisms involved and the effect of environmental factors on microbial comm...
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Article
Open AccessMetabolic engineering to enhance biosynthesis of both docosahexaenoic acid and odd-chain fatty acids in Schizochytrium sp. S31
Docosahexaenoic acid (DHA, C22:6) and odd-chain fatty acids (OCFAs, C15:0 and C17:0) have attracted great interest, since they have been widely used in food and therapeutic industries, as well as chemical indu...
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Article
Selective deposition of Au-Pt alloy nanoparticles on ellipsoidal zirconium titanium oxides for reduction of 4-nitrophenol
Au-Pt alloy nanoparticles that are selectively anchored on TiO2 surface of the ellipsoidal zirconium titanium composite oxides were successfully prepared by a facile two-step method: prefabricated binary composit...
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Article
FIP-sch2, a new fungal immunomodulatory protein from Stachybotrys chlorohalonata, suppresses proliferation and migration in lung cancer cells
Fungal immunomodulatory protein (FIP)-sch2, an immunomodulatory protein identified in the ascomycete Stachybotrys chlorohalonata by a sequence similarity search, is a novel member of the FIP family. FIP-sch2 shar...
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Article
Contributing factors in the improvement of cellulosic H2 production in Clostridium thermocellum/Thermoanaerobacterium co-cultures
Lignocellulosic biohydrogen is a promising renewable energy source that could be a potential alternative to the unsustainable fossil fuel-based energy. Biohydrogen production could be performed by Clostridium the...
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Article
Open AccessAn environmentally friendly and productive process for bioethanol production from potato waste
China is the largest sweet potato producer and exporter in the world. Sweet potato residues (SPRs) separated after extracting starch account for more than 10 % of the total dry matter of sweet potatoes. In Chi...
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Article
Fine genetic map** of spot blotch resistance gene Sb3 in wheat (Triticum aestivum)
Spot blotch disease resistance gene Sb3 was mapped to a 0.15 centimorgan (cM) genetic interval spanning a 602 kb physical genomic region on chromosome 3BS.
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Article
Regulation of cellulase expression, sporulation, and morphogenesis by velvet family proteins in Trichoderma reesei
Homologs of the velvet protein family are encoded by the ve1, vel2, and vel3 genes in Trichoderma reesei. To test their regulatory functions, the velvet protein-coding genes were disrupted, generating Δve1, Δvel2
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Article
Genetic diversity of resynthesized Brassica napus lines from SW China assessed by main agronomic traits and SSR markers in comparison with common B. napus lines
Genetic diversity of 96 resynthesized (RS) Brassica napus lines and 25 common (CM) lines were evaluated in present study based on eight main agronomic traits and 315 polymorphic SSR markers. The RS lines were dev...
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Article
Voltage-Gated Potassium+ Channel Expression in Coronary Artery Smooth Muscle Cells of SHR and WKY
This study aims to compare the expression of genes and the molecular characteristic of voltage-gated K+ channels, which make great effort in maintaining and controlling smooth muscle contraction, cellular membran...
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Article
Sodium houttuyfonate, a potential phytoanticipin derivative of antibacterial agent, inhibits bacterial attachment and pyocyanine secretion of Pseudomonas aeruginosa by attenuating flagella-mediated swimming motility
Pseudomonas aeruginosa is a well-known clinical pathogen for its recalcitrant infection caused by biofilm formation which are initiated by flagella-mediated attachment. Sodium houttuyfonate (SH) ...
