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Life Sciences
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Article
Spatial distribution of clogging substances in drip irrigation emitters fed with reclaimed water
Utilizing reclaimed water by drip irrigation technology proves to be an effective strategy for mitigating agricultural water scarcity. Nevertheless, the formation of clogging substances within emitter flow cha...
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Open AccessDexmedetomidine and argon in combination against ferroptosis through tackling TXNIP-mediated oxidative stress in DCD porcine livers
Graft availability from donation after circulatory death (DCD) is significantly limited by ischaemia reperfusion (IR) injury. Effective strategies to mitigate IR injury in DCD grafts are essential to improve g...
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Article
Meta-Analysis Study on the Role of Biochar on Soil Nitrogen Cycling
Soil nitrogen cycling is intricately related to soil physicochemical properties, enzymatic activity, and microbial vitality. Biochar, containing various elements such as carbon, nitrogen, and phosphorus, posse...
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Potential Yield of Potato Under Global Warming Based on an ARIMA-TR Model
As an important food crop in the world, potato has been attracting scholarly attention to improve its yield in the future, particularly under climate change. Therefore, analyzing the potential yield of potato ...
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Open AccessIntegrating ecosystem services, stakeholders’ perspective, and land-use scenarios to safeguard sustainability of the Mulberry-Dyke and Fish-Pond System
Optimizing landscape patterns by considering ecosystem services and human well-being is crucial for landscape sustainability research. Such optimization process shall also consider multiple stakeholders’ persp...
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Overexpression of sweetpotato glutamylcysteine synthetase (IbGCS) in Arabidopsis confers tolerance to drought and salt stresses
Various environmental stresses induce the production of reactive oxygen species (ROS), which have deleterious effects on plant cells. Glutathione (GSH) is an antioxidant used to counteract reactive oxygen spec...
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Arbuscular mycorrhizal fungi-mediated drought stress tolerance in kenaf (hibiscus cannabinus l.): a mechanistic approach
Drought is one of the important factors limiting crop growth. Plants can enhance resistance to various stressors by forming symbiotic relationships with arbuscular mycorrhizal fungi (AMF). However, the regulat...
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Overexpressing Bcl-2 enhances murine chimeric antigen receptor T cell therapy against solid tumor
Chimeric antigen receptor T (CART) cell therapy has demonstrated promising potential in the treatment of hematologic malignancies. However, its application to solid tumors is limited due to the restrictive nat...
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Article
Analysis of Root Response Mechanism of Quinoa Seedlings to Waterlogging Stress Based on Metabolome
Quinoa, a dicotyledonous annual herb belonging to the subfamily Amaranthaceae, has remarkable resistance to cold, drought, and barren conditions. However, few studies have reported on quinoa root metabolism un...
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Article
Open AccessTemporal turnover of viral biodiversity and functional potential in intertidal wetlands
As the central members of the microbiome networks, viruses regulate the composition of microbial communities and drive the nutrient cycles of ecosystems by lysing host cells. Therefore, uncovering the dynamic ...
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Open AccessRapid reconstitution of ubiquitinated nucleosome using a non-denatured histone octamer ubiquitylation approach
Histone ubiquitination modification is emerging as a critical epigenetic mechanism involved in a range of biological processes. In vitro reconstitution of ubiquitinated nucleosomes is pivotal for elucidating t...
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Open AccessIntegrated analysis of transcriptomics and metabolomics of garden asparagus (Asparagus officinalis L.) under drought stress
Drought is a leading environmental factor affecting plant growth. To explore the drought tolerance mechanism of asparagus, this study analyzed the responses of two asparagus varieties, namely, ‘Jilv3’ (drought...
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Open AccessNicotine-induced activation of cholinergic receptor nicotinic alpha 5 subunit mediates the malignant behaviours of laryngeal squamous epithelial cells by interacting with RABL6
Nicotine, a crucial constituent of tobacco smoke, can bind to and activate nicotinic acetylcholine receptors (nAChRs), thereby regulating various biological functions. However, the specific mechanisms through ...
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Synergistic effect of chimeric antigen receptor modified with Bcl-2 on enhanced solid tumour targeting
Engineered T cells expressing chimeric antigen receptors (CARs) have shown remarkable therapeutic effects on haematological malignancies. However, CART cells are less effective on solid tumours mainly due to t...
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Article
Effects of various fertilizers on sediment flocculation in high-sediment water drip irrigation systems
High-sediment water (HSW) drip irrigation has the potential to address agricultural water shortages. However, the sediment flocculation in HSW causes serious technical and economic problems (e.g., emitter clog...
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Article
Open AccessRegulated cell death in hypoxic-ischaemic encephalopathy: recent development and mechanistic overview
Hypoxic-ischaemic encephalopathy (HIE) in termed infants remains a significant cause of morbidity and mortality worldwide despite the introduction of therapeutic hypothermia. Depending on the cell type, cellul...
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Article
STAT1 aggravates kidney injury by NOD-like receptor (NLRP3) signaling in MRL-lpr mice
Systemic lupus erythematosus (SLE) is a persistent autoimmune disorder that can culminate in lupus nephritis (LN), an intricate renal complication. In pursuit of unraveling the intricate molecular underpinning...
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Characterization of the tubby-like proteins (TLPs) gene family in Cucumis sativus L.: insights into the evolution, structure, and expression patterns under salt stress
Cucumber (Cucumis sativus L.) is a member of the Cucurbitaceae family and can be eaten raw in salads or cooked as a vegetable. The yield of cucumber is limited due to many factors including biotic and abiotic str...
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Correction to: Soybean triggers tomato root horizontal asymmetry by modifying capture of P rather than N under low nutrient condition
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Article
Mammalian IRE1α dynamically and functionally coalesces with stress granules
Upon endoplasmic reticulum (ER) stress, activation of the ER-resident transmembrane protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1) initiates a key branch of the unfolded protein response (U...
