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Article
Open AccessThe abnormalities of free fatty acid metabolism in patients with hypertrophic cardiomyopathy, a single-center retrospective observational study
Previous studies have shown the importance of energy deficiency and malfunctioning mitochondria in the pathophysiology of hypertrophic cardiomyopathy (HCM). There has been a little research into the relationsh...
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Chapter
Biogenesis and Functions of Extracellular Vesicles
Extracellular vesicles (EVs) contain various biomolecules, including proteins, nucleic acids, lipids, and metabolites. Multiple intracellular trafficking mechanisms are involved in EV biogenesis and secretion....
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Article
Open AccessSpatial effects of public health laboratory emergency testing institutions under COVID-19 in China
The transmission of 2019 novel coronavirus (COVID-19) has caused global panic in the past three years. Countries have learned an important lesson in the practice of responding to COVID-19 pandemic: timely and ...
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Article
Open AccessBlood unconjugated bilirubin and tacrolimus are negative predictors of specific cellular immunity in kidney transplant recipients after SAR-CoV-2 inactivated vaccination
The immunogenicity of SARS-CoV-2 vaccines is poor in kidney transplant recipients (KTRs). The factors related to poor immunogenicity to vaccination in KTRs are not well defined. Here, observational study demon...
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Article
Open AccessMigration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model
Down syndrome (DS) is the most common chromosomal abnormality in live-born infants and is caused by trisomy of chromosome 21. Most individuals with DS display craniofacial dysmorphology, including reduced size...
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Article
Open AccessSpatial effects of air pollution on the economic burden of disease: implications of health and environment crisis in a post-COVID-19 world
Air pollution has been identified as related to the diseases of susceptible population, but the spatial heterogeneity of its economic burden and its determinants are rarely investigated. The issue is of great ...
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Open AccessDegree of protection provided by poverty alleviation policies for the middle-aged and older in China: evaluation of effectiveness of medical insurance system tools and vulnerable target recognition
China’s medical insurance schemes and poverty alleviation policy at this stage have achieved population-wide coverage and the system's universal function. At the late stage of the elimination of absolute pover...
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Article
Open AccessFactors that dynamically affect provincial incidences of catastrophic health expenditure among middle-aged and elderly Chinese population-transition of disease financial risk protection from global to local
The high incidence of catastrophic health expenditure (ICHE) among middle-aged and elderly population is a major deterrent for reducing the financial risk of disease. Current research is predominantly based on...
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Article
Open AccessIntegrative network analysis of circular RNAs reveals regulatory mechanisms for hepatic specification of human iPSC-derived endoderm
Human-induced pluripotent stem cell (hiPSC)-derived functional hepatic endoderm (HE) is supposed to be an alternative option for replacement therapy for end-stage liver disease. However, the high heterogeneity...
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Open AccessThe superposition effects of air pollution on government health expenditure in China— spatial evidence from GeoDetector
As the fifth-largest global mortality risk factor, air pollution has caused nearly one-tenth of the world’s deaths, with a death toll of 5 million. 21% of China’s disease burden was related to environmental po...
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Open AccessMulti-dimensional vulnerability analysis on catastrophic health expenditure among middle-aged and older adults with chronic diseases in China
Middle-aged and older adults are more likely to suffer from chronic diseases because of their particular health characteristics, which lead to a high incidence of catastrophic health expenditure (CHE). This st...
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Article
Open AccessGeneration of in situ CRISPR-mediated primary and metastatic cancer from monkey liver
Non-human primates (NHPs) represent the most valuable animals for drug discovery. However, the current main challenge remains that the NHP has not yet been used to develop an efficient translational medicine p...
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Article
Open AccessAutologous transplantation of thecal stem cells restores ovarian function in nonhuman primates
Premature ovarian insufficiency (POI) is defined as the loss of ovarian activity under the age of 40. Theca cells (TCs) play a vital role during folliculogenesis and TCs dysfunction participate in the pathogen...
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Article
Open AccessSOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells
Animal studies have indicated that SOX10 is one of the key transcription factors regulating the proliferation, migration and differentiation of multipotent neural crest (NC), and mutation of SOX10 in humans may l...
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Article
Open AccessImpact of type 2 diabetes mellitus on mid-term mortality for hypertrophic cardiomyopathy patients who underwent septal myectomy
Type 2 diabetes mellitus is common in cardiovascular disease. It is associated with adverse clinical outcomes for patients who had undergone coronary artery bypass and valve operations. The aim of this study w...
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Article
Open AccessAn Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles
How to deliver chemotherapeutic drugs efficiently and selectively to tumor cells to improve therapeutic efficacy remains a difficult problem. We herein construct an efficient cell-targeting drug delivery syste...
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Article
Open AccessHERC2 regulates RPA2 by mediating ATR-induced Ser33 phosphorylation and ubiquitin-dependent degradation
Replication protein A (RPA) binds to and stabilizes single-stranded DNA and is essential for the genome stability. We reported that an E3 ubiquitin ligase, HERC2, suppresses G-quadruplex (G4) DNA by regulating...
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Article
Open AccessThe characteristic, antioxidative and multiple organ protective of acidic-extractable mycelium polysaccharides by Pleurotus eryngii var. tuoliensis on high-fat emulsion induced-hypertriglyceridemic mice
The antioxidant and multiple organ protection effects of acid- extracted mycelia polysaccharides (Ac-MPS) from Pleurotus eryngii var. tuoliensis on HFE-induced hypertriglyceridemic mice were investigated. The res...
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Article
A 14-bit 500-MS/s DAC with 211-MHz 70 dB SFDR bandwidth using TRI-DEMRZ
Time-relaxed interleaving dynamic element matching return-to-zero (TRI-DEMRZ) is proposed and verified in this paper to improve the spurious-free dynamic range (SFDR) of current-steering digital-to-analog conv...
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Open AccessMesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis
Crohn’s disease (CD) is a chronic inflammatory bowel disease that is difficult to treat. However, previous preclinical and clinical studies have shown that mesenchymal stromal cells (MSCs) are a promising ther...
