45 Result(s)
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**ngnan Zhang
Life Sciences
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Article
Quercetin Alleviates Perimenopausal Depression Induced by Ovariectomy Combined with Chronic Unpredictable Mild Stress Through Regulating Serum Elements and Inhibiting Ferroptosis in Prefrontal Cortex of Rats
This study investigated the effects of quercetin on the alterations of serum elements in perimenopausal depression rat model induced by ovariectomy combined with chronic unpredictable mild stress (OVX-CUMS) an...
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Associations of sugar-sweetened, artificially sweetened, and naturally sweet juices with Alzheimer’s disease: a prospective cohort study
Epidemiological studies of sugar-sweetened beverages (SSBs) and artificially sweetened beverages (ASBs) with Alzheimer’s disease (AD) have provided controversial findings. Furthermore, little is known about th...
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Establishment and characterization of a recurrent malignant peripheral nerve sheath tumor cell line: RsNF
Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive and recurrent soft tissue sarcoma. It most commonly occurs secondary to neurofibromatosis type I, and it has a 5-year survival rate of onl...
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Andrographolide attenuated MCT-induced HSOS via regulating NRF2-initiated mitochondrial biogenesis and antioxidant response
Hepatic sinusoidal obstruction syndrome (HSOS) is a death-dealing liver disease with a fatality rate of up to 67%. In the study present, we explored the efficacy of andrographolide (Andro), a diterpene lactone...
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Open AccessInduction of tetraploids in Paper Mulberry (Broussonetia papyrifera (L.) L’Hér. ex Vent.) by colchicine
Broussonetia papyrifera (L.) L’Hér. ex Vent. has the characteristics of strong stress resistance, high crude protein content, and pruning tolerance. It is an ecological, economic, and medicinal plant. Polyploid p...
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The active role of comammox Nitrospira in nitrification in acidic orchard soils revealed by DNA-SIP
The recently discovered complete ammonia oxidizers (comammox Nitrospira) have fundamentally changed the perceptions of two-step nitrification. Previous studies suggest that comammox Nitrospira may outcompete cano...
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Screening and Identification of Probiotic Lactobacilli from the Infant Gut Microbiota to Alleviate Lead Toxicity
Lead (Pb2+) exposure cause a potential hazard to human health and the ecological environment; however, prevention and treatment of Pb2+ toxicity remain problems. The aim of this study is to isolate a novel probio...
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Open AccessPlasma cell-free DNA promise monitoring and tissue injury assessment of COVID-19
Coronavirus 2019 (COVID-19) is a complex disease that affects billions of people worldwide. Currently, effective etiological treatment of COVID-19 is still lacking; COVID-19 also causes damages to various orga...
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Fibroblasts and mouse breast cancer cells can form cellular aggregates in improved soft agar culture medium
We aimed to build cellular aggregates of TS/A and normal fibroblasts (LX-2) or CAFs (ME-iLX-2), verifying the value of this model in the screening of anticancer drugs and demonstrating the effect of CD44 on ag...
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Open AccessMultiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C
Technology for measuring 3D genome topology is increasingly important for studying gene regulation, for genome assembly and for map** of genome rearrangements. Hi-C and other ligation-based methods have beco...
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Open AccessZeb1 facilitates corneal epithelial wound healing by maintaining corneal epithelial cell viability and mobility
The cornea is the outmost ocular tissue and plays an important role in protecting the eye from environmental insults. Corneal epithelial wounding provokes pain and fear and contributes to the most ocular traum...
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Open AccessA benchmark study of deep learning-based multi-omics data fusion methods for cancer
A fused method using a combination of multi-omics data enables a comprehensive study of complex biological processes and highlights the interrelationship of relevant biomolecules and their functions. Driven by...
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Open AccessSARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation
The nucleocapsid (N) protein of SARS-CoV-2 has been reported to have a high ability of liquid-liquid phase separation, which enables its incorporation into stress granules (SGs) of host cells. However, whether...
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Open AccessDecoding the pathogenesis of Diamond–Blackfan anemia using single-cell RNA-seq
Ribosomal protein dysfunction causes diverse human diseases, including Diamond–Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the mechanisms underlying ribosomopathies, whic...
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Polysaccharide, proline, and anti-oxidation enzyme activities of Thailand rosewood (Dalbergia cochinchinensis) seedlings exposed to exponential fertilization
Thailand rosewood (Dalbergia cochinchinensis) is a vulnerable high value tree species in subtropical and tropical Southeast Asia. The demand for the rehabilitation of the natural habitat of the species requires h...
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Open AccessBNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease
Mitophagy is a highly conserved cellular process that maintains the mitochondrial quantity by eliminating dysfunctional or superfluous mitochondria through autophagy machinery. The mitochondrial outer membrane...
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Open AccessEffects of various artificial agarwood-induction techniques on the metabolome of Aquilaria sinensis
Agarwood is a highly sought-after resinous wood for uses in medicine, incense, and perfume production. To overcome challenges associated with agarwood production in Aquilaria sinensis, several artificial agarwood...
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Open AccessComparative transcriptome analysis reveals that chlorophyll metabolism contributes to leaf color changes in wucai (Brassica campestris L.) in response to cold
Chlorophyll (Chl) is a vital photosynthetic pigment involved in capturing light energy and energy conversion. In this study, the color conversion of inner-leaves from green to yellow in the new wucai (Brassica ca...
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Open AccessA complete mitochondrial genome for fragrant Chinese rosewood (Dalbergia odorifera, Fabaceae) with comparative analyses of genome structure and intergenomic sequence transfers
Dalbergia odorifera is an economically and culturally important species in the Fabaceae because of the high-quality lumber and traditional Chinese medicines made from this plant, however, overexploitation has inc...
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Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation
