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Article
Open AccessKnowledge, attitudes, and practice related to tooth loss and dentures among patients with dental arch deficiencies
Tooth loss is a common problem that affects many people worldwide. Exploring knowledge, attitude, and practice (KAP) among patients can identify barriers and challenges in following recommended practices, prov...
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Article
Study on the characteristics of tungsten slag and its properties in the cement solidification system
The basic characteristics of tungsten slag produced in the production of ammonium para tungstate (APT) and its ground tungsten slag powder were investigated. The mechanical strength characteristics and develop...
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Article
Paeonol upregulates expression of tumor suppressors TNNC1 and SCARA5, exerting anti-tumor activity in non-small cell lung cancer cells
Paeonol, a naturally bioactive phenolic ingredient predominantly isolated from Paeonia suffruticosa, has recently garnered significant interest as an anti-tumor agent against diverse carcinomas including non-smal...
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Article
Finotonlimab with chemotherapy in recurrent or metastatic head and neck cancer: a randomized phase 3 trial
Immunotherapy combined with chemotherapy regimen has been shown to be effective in recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). However, due to the small number of patients, its...
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Article
Phase evolution and critical current density during post-annealing in Bi-2223/AgAu tapes
37-filamentary Bi2Sr2Ca2Cu3O10+δ (Bi-2223) superconducting tapes were prepared by powder-in-tube (PIT) technique. During the second heat treatment process (HT2), tapes were sintered at 826 °C for different time a...
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Article
Dithieno[3,2-c:3′,2′-h][2,6]naphthyridine-4,9(5H,10H)-dione-based Quinoidal Small Molecules: Synthesis, Properties, and Optoelectronic Applications
Amide and imide groups have been widely used in the design of organic semiconductors, and the development of new structure semiconductors based on these functional groups is of great interest to further improv...
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Article
Open AccessCD151-enriched migrasomes mediate hepatocellular carcinoma invasion by conditioning cancer cells and promoting angiogenesis
The tetraspanin family plays a pivotal role in the genesis of migrasomes, and Tetraspanin CD151 is also implicated in neovascularization within tumorous contexts. Nevertheless, research pertaining to the invol...
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Article
Spinal cord and brain atrophy patterns in neuromyelitis optica spectrum disorder and multiple sclerosis
Spinal cord and brain atrophy are common in neuromyelitis optica spectrum disorder (NMOSD) and relapsing-remitting multiple sclerosis (RRMS) but harbor distinct patterns accounting for disability and cognitive...
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Article
An efficient and universal polygon prediction method based on derivable analytic geometry for arbitrary-shaped text detection
A polygon can represent the boundary of curved text more compactly than a rectangle. However, predicting reasonable polygon lacks of solutions due to the complex spatial relationships caused by having more ver...
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Article
Open AccessAplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein
Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3...
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Article
Open AccessAutomatic grid topology detection method based on Lasso algorithm and t-SNE algorithm
For a long time, the low-voltage distribution network has the problems of untimely management and complex and frequently changing lines, which makes the problem of missing grid topology information increasingl...
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Article
Open AccessIn-situ noncovalent interaction of ammonium ion enabled C–H bond functionalization of polyethylene glycols
The noncovalent interactions of ammonium ion with multidentate oxygen-based host has never been reported as a reacting center in catalytic reactions. In this work, we report a reactivity enhancement process en...
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Article
Open AccessCystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region
Cystine-knot peptides (CKPs) are naturally occurring peptides that exhibit exceptional chemical and proteolytic stability. We leveraged the CKP carboxypeptidase A1 inhibitor as a scaffold to construct phage-di...
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Article
Advancements in assessing soil health through functional traits and energy flow analysis of soil nematodes
We examined the development of soil nematodes ecological indices from the perspective of functional traits.
We found that so...
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Article
Precisely succinonitrile-functionalized PEO electrolytes toward room-temperature all-solid-state lithium batteries
Polyethylene oxide) (PEO) polymer electrolytes have the potential for the use in all-solid-state lithium-metal batteries (ASSLMBs). However, no effective rules have been proposed to prepare all-solid-state PEO...
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Article
Synergism effect of Pb do** and microstructure optimization on the superconducting properties of Bi-2212 ceramics
Bi-2212 is one of the most competitive high-temperature superconducting materials for the fabrication of high field magnet, but its superconducting transmission mechanism is not clear yet. To further investiga...
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Article
Open AccessExperimental study on the effect of loading rate on the strain energy accumulation and release during the weakening process of circular-tunnel
The weakening of circular tunnels is a global problem that has not been resolved satisfactorily. In the tunnelling process, surrounding rock of circular-tunnel performs a process of “excavating → weakening → c...
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Article
Open AccessHalogen doped graphene quantum dots modulate TDP-43 phase separation and aggregation in the nucleus
TDP-43 is implicated in the dynamic formation of nuclear bodies and stress granules through phase separation. In diseased states, it can further condense into pathological aggregates in the nucleus and cytopla...
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Article
Retraction Note: Two Mixed Ligand Coordination Polymers: Selective Detection of TNP and Protective Effect on Alzheimer’s Disease by Stimulating Cell Autophagy
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Article
Open AccessPhosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures
α-Synuclein forms amyloid fibrils that are critical in the progression of Parkinson’s disease and serves as the pathological hallmark of this condition. Different posttranslational modifications have been iden...
