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Open AccessHybrid ant colony-based inter-cluster routing protocol for FANET
This study addresses the challenges in large-scale unmanned aerial vehicle (UAV) clusters, specifically the scalability issues and limitations of using reactive routing protocols for inter-cluster routing. The...
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Article
Open AccessIntegrating Iso-seq and RNA-seq data for the reannotation of the greater amberjack genome
The greater amberjack is a very important fishery species with high commercial value, and it is distributed worldwide. Transcriptome-based studies on S. dumerili have been limited by an inadequate reference genom...
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Article
Open AccessSynergistic oxidation of toluene through bimetal/cordierite monolithic catalysts with ozone
Toluene treatment has received extensive attention, and ozone synergistic catalytic oxidation was thought to be a potential method to degrade VOCs (violate organic compounds) due to its low reaction temperatur...
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Open AccessCharacteristics of germline DNA damage response gene mutations in ovarian cancer in Southwest China
DNA damage response (DDR) pathways are responsible for repairing endogenous or exogenous DNA damage to maintain the stability of the cellular genome, including homologous recombination repair (HRR) pathway, mi...
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Open AccessA pancancer analysis of the clinical and genomic characteristics of multiple primary cancers
Multiple primary cancer (MPC) denotes individuals with two or more malignant tumors occurring simultaneously or successively. Herein, a total of 11,000 pancancer patients in TCGA database (1993–2013) were divi...
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Open AccessInvestigating the bearing performance of the foundation under the combined effects of flood scouring and soaking
Bearing capacity degradation of foundations under the impact of the flood is one of the major reasons responsible for the collapse and damage to the rural buildings, posing a serious threat to the local villag...
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Article
Open AccessStructural basis of peptide secretion for Quorum sensing by ComA
Quorum sensing (QS) is a crucial regulatory mechanism controlling bacterial signalling and holds promise for novel therapies against antimicrobial resistance. In Gram-positive bacteria, such as Streptococcus pneu...
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Open AccessAttenuates reactive oxygen species: induced pyroptosis via activation of the Nrf2/HO-1 signal pathway in models of trigeminal neuralgia
In this study, we examined the impact of demyelinating and neuroinflammation on trigeminal neuralgia (TN) by utilizing models of chronic constriction injury to the infraorbital nerve (CCI). The CCI rats were t...
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Open AccessA pilot study of lymphodepletion intensity for peripheral blood mononuclear cell-derived neoantigen-specific CD8 + T cell therapy in patients with advanced solid tumors
Currently, the optimal lymphodepletion intensity for peripheral blood mononuclear cell-derived neoantigen-specific CD8 + T cell (Neo-T) therapy has yet to be determined. We report a single-arm, open-label and ...
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Article
Open AccessPregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions
Citrus fruit has long been considered a healthy food, but its role and detailed mechanism in lifespan extension are not clear. Here, by using the nematode C. elegans, we identified that nomilin, a bitter-taste li...
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Article
Open AccessIdentification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy
Circular RNAs (circRNAs) play important roles in the regulation of cancer. However, the clinical implications and regulatory networks of circRNAs in cancer patients receiving immune checkpoint blockades (ICB) ...
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Article
Open AccessThe melanocortin action is biased toward protection from weight loss in mice
The melanocortin action is well perceived for its ability to regulate body weight bidirectionally with its gain of function reducing body weight and loss of function promoting obesity. However, this notion can...
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Open AccessAuthor Correction: Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis
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Article
Ladderphane copolymers for high-temperature capacitive energy storage
For capacitive energy storage at elevated temperatures1–4, dielectric polymers are required to integrate low electrical conduction with high thermal conductivity. The coexistence of these seemingly contradictory ...
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Open AccessIntegrative proteomic characterization of adenocarcinoma of esophagogastric junction
The incidence of adenocarcinoma of the esophagogastric junction (AEG) has been rapidly increasing in recent decades, but its molecular alterations and subtypes are still obscure. Here, we conduct proteomics an...
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Open AccessUbiquilin-2 regulates pathological alpha-synuclein
The key protein implicated in Parkinson’s disease and other synucleinopathies is α-synuclein, and a post-translationally modified form of the protein, phosphorylated at serine 129 (pS129), is a principal compo...
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Open AccessIdentification of RT-qPCR reference genes suitable for gene function studies in the pitaya canker disease pathogen Neoscytalidium dimidiatum
Neoscytalidium dimidiatum is the main causal agent of pitaya canker. Most studies of virulence and pathogenicity genes have measured expression levels using real-time quantitative polymerase chain reaction (RT-qP...
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Open AccessDecoupling light absorption and carrier transport via heterogeneous do** in Ta3N5 thin film photoanode
The trade-off between light absorption and carrier transport in semiconductor thin film photoelectrodes is a major limiting factor of their solar-to-hydrogen efficiency for photoelectrochemical water splitting...
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Integrating crop redistribution and improved management towards meeting China’s food demand with lower environmental costs
China feeds 19.1% of the world’s population with 8.6% of the arable land. Here we propose an integrated approach combining crop redistribution and improved management to meet China’s food demand in 2030. We si...
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Open AccessSystematic characterization of cancer transcriptome at transcript resolution
Transcribed RNAs undergo various regulation and modification to become functional transcripts. Notably, cancer transcriptome has not been fully characterized at transcript resolution. Herein, we carry out a re...