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Article
Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587
Bedaquiline (BDQ), a first-in-class diarylquinoline anti-tuberculosis drug, and its analogue, TBAJ-587, prevent the growth and proliferation of Mycobacterium tuberculosis by inhibiting ATP synthase1,2. However, B...
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Author Correction: MYC phase separation selectively modulates the transcriptome
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Open AccessAssociation of weight-adjusted waist index with all-cause mortality among non-Asian individuals: a national population-based cohort study
The Weight-Adjusted Waist Index (WWI) is a new indicator of obesity that is associated with all-cause mortality in Asian populations. Our study aimed to investigate the linear and non-linear associations betwe...
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Open AccessFarnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein
Respiratory syncytial virus (RSV) is the major cause of bronchiolitis and pneumonia in young children and the elderly. There are currently no approved RSV-specific therapeutic small molecules available. Using ...
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Article
Open AccessPathogenic role and clinical significance of neutrophils and neutrophil extracellular traps in idiopathic inflammatory myopathies
Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of chronic autoimmune diseases characterized by muscle damage and extramuscular symptoms, including specific skin rash, arthritis, interstitia...
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Article
MYC phase separation selectively modulates the transcriptome
Dysregulation and enhanced expression of MYC transcription factors (TFs) including MYC and MYCN contribute to the majority of human cancers. For example, MYCN is amplified up to several hundredfold in high-risk n...
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Article
Open AccessEvaluating the diagnostic accuracy of heat shock proteins and their combination with Alpha-Fetoprotein in the detection of hepatocellular carcinoma: a meta-analysis
A growing body of research suggests that heat shock proteins (HSPs) may serve as diagnostic biomarkers for hepatocellular carcinoma (HCC), but their results are still controversial. This meta-analysis endeavor...
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Open AccessYTHDF2-Mediated m6A methylation inhibition by miR27a as a protective mechanism against hormonal osteonecrosis in BMSCs
With the increasing incidence of steroid-induced necrosis of the femoral head (SNFH), numerous scholars have investigated its pathogenesis. Current evidence suggests that the imbalance between lipogenesis and ...
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Article
Open AccessAn adeno-associated virus variant enabling efficient ocular-directed gene delivery across species
Recombinant adeno-associated viruses (rAAVs) have emerged as promising gene therapy vectors due to their proven efficacy and safety in clinical applications. In non-human primates (NHPs), rAAVs are administere...
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Article
The Effect of Heat Treatment Methods on the Structural Characteristics of Basalt Glass
The purpose of present work was clarified the structural information of complex silicate glass, find out links between basalt glass structures and basalt fibers, and provide theoretical support for the selecti...
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Article
Open AccessPredictive modeling of co-infection in lupus nephritis using multiple machine learning algorithms
This study aimed to analyze peripheral blood lymphocyte subsets in lupus nephritis (LN) patients and use machine learning (ML) methods to establish an effective algorithm for predicting co-infection in LN. Thi...
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Open AccessMacrophage-derived mir-100-5p orchestrates synovial proliferation and inflammation in rheumatoid arthritis through mTOR signaling
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation, causing substantial disability and reducing life quality. While macrophages are widely appreciated as a master...
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Article
Open AccessComparative efficacy and safety of all kinds of intraocular lenses in presbyopia-correcting cataract surgery: a systematic review and meta-analysis
To assess the efficacy and safety of various intraocular lenses (IOLs), including standard monofocal, bifocal, trifocal, extended depth of focus (EDOF), and enhanced monofocal IOLs, post-cataract surgery throu...
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Article
ZNF26-Associated Genes as Prognostic Signatures in Colorectal Cancer with Broad Therapeutic Implications
The identification of biomarkers correlated with colorectal cancer (CRC) prognosis holds substantial importance from both clinical and scientific perspectives. Zinc finger protein 26 (ZNF26) has not been previ...
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Article
Global Sensitivity Analysis of Crop Parameters Based on AquaCrop Model
When the model is applied to a new area, the first thing to consider is the problem of localization correction, and parameter sensitivity analysis is an important part of it. In this study, the AquaCrop model ...
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Open AccessWater management scheme based on prioritized deep deterministic policy gradient for proton exchange membrane fuel cells
To effectively tackle the intricate and dynamic challenges encountered in proton exchange membrane fuel cells (PEMFCs), this paper introduces a model-free reinforcement learning approach to address its water m...
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Article
Modified EASIX scores predict severe CRS/ICANS in patients with acute myeloid leukemia following CLL1 CAR-T cell therapy
Chimeric antigen receptor T (CAR-T) cell therapy targeting CLL1 has been considered a potent weapon for patients with acute myeloid leukemia (AML). This study aims to evaluate the efficacy and toxicity of CLL1...
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Article
Cascaded refinement residual attention network for image outpainting
The image outpainting based on deep learning shows good performance and has a wide range of applications in many fields. The previous image outpainting methods mostly used a single image as input. In this pape...
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Article
Analysis of surface water area dynamics and driving forces in the Bosten Lake basin based on GEE and SEM for the period 2000 to 2021
As an inland dryland lake basin, the rivers and lakes within the Lake Bosten basin provide scarce but valuable water resources for a fragile environment and play a vital role in the development and sustainabil...
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Open AccessAssociations of cereal fiber intake with rheumatoid arthritis mediated by dietary inflammatory index: insights from NHANES 2011–2020
Rheumatoid Arthritis (RA) is an increasingly prevalent inflammatory disorder worldwide. Its complex etiology has recently brought dietary factors, particularly fiber intake, into focus as potential influencers...
